Pharmacodynamic biomarkers for quantifying the mycobacterial effect of high doses of rifampin in patients with rifampin-susceptible pulmonary tuberculosis

Autor: Bibie N Said, Scott K Heysell, Getnet Yimer, Rob E Aarnoutse, Gibson S Kibiki, Stellah Mpagama, Peter M Mbelele

Publikováno v: International Journal of Mycobacteriology, Vol 10, Iss 4, Pp 457-462 (2021)

Background: Suboptimal drug exposure in patients with drug-susceptible tuberculosis (DS-TB) can drive treatment failure. Pharmacodynamics (PD) biomarkers such as the plasma TB drug-activity (TDA) assay may guide dose finding studies and predict micro

Externí odkaz: https://doaj.org/article/0f51216d379d4e0699fd186dd57e9372

Clinical application of whole-genome sequencing in the management of extensively drug-resistant tuberculosis: a case report

Autor: Bugwesa Z. Katale, Sylvia Rofael, Linzy Elton, Erasto V. Mbugi, Stella G. Mpagama, Daphne Mtunga, Maryjesca G. Mafie, Peter M. Mbelele, Charlotte Williams, Happiness C. Mvungi, Rachel Williams, Gulinja A. Saku, Joanitha A. Ruta, Timothy D. McHugh, Mecky I. Matee

Publikováno v: Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-10 (2024)

Abstract Background Whole-genome sequencing (WGS)-based prediction of drug resistance in Mycobacterium tuberculosis has the potential to guide clinical decisions in the design of optimal treatment regimens. Methods We utilized WGS to investigate drug

Externí odkaz: https://doaj.org/article/d198dc7b488e4a8689c23e834a7f6c50

Protocol for a feasibility randomized controlled trial to evaluate the efficacy, safety and tolerability of N-acetylcysteine in reducing adverse drug reactions among adults treated for multidrug-resistant tuberculosis in Tanzania

Autor: Stellah G. Mpagama, Happiness C. Mvungi, Peter M. Mbelele, Hadija H. Semvua, Alphonce A. Liyoyo, Kristen Petros de Guex, Derek Sloan, Gibson S. Kibiki, Martin Boeree, Patrick P. J. Phillips, Scott K. Heysell

Publikováno v: Pilot and Feasibility Studies, Vol 9, Iss 1, Pp 1-13 (2023)

Abstract Background Adverse drug reactions (ADRs) frequently occur in patients using second-line anti-tuberculosis medicine for treatment of multidrug resistant tuberculosis (MDR-TB). ADRs contribute to treatment interruptions which can compromise tr

Externí odkaz: https://doaj.org/article/fac1e3f6fde94e79b20253eb7f51782e

Impact of early diagnosis of impaired glucose regulation in tuberculosis: Comparison of clinical outcomes in people with tuberculosis in Tanzania

Autor: Kenneth C, Byashalira, Nyasatu G, Chamba, Yosra, Alkabab, Peter M, Mbelele, Emmanuel A, Mpolya, Nyanda E, Ntinginya, PendoMartha J, Shayo, Kaushik L, Ramaiya, Troels, Lillebaek, Scott K, Heysell, Blandina T, Mmbaga, Ib C, Bygbjerg, Stellah G, Mpagama, Dirk L, Christensen

Publikováno v: Byashalira, K C, Chamba, N G, Alkabab, Y, Mbelele, P M, Mpolya, E A, Ntinginya, N E, Shayo, P J, Ramaiya, K L, Lillebaek, T, Heysell, S K, Mmbaga, B T, Bygbjerg, I C, Mpagama, S G, Christensen, D L & ADEPT Consortium 2022, ' Impact of early diagnosis of impaired glucose regulation in tuberculosis : Comparison of clinical outcomes in people with tuberculosis in Tanzania ', Tropical Medicine & International Health, vol. 27, no. 9, pp. 815-822 . https://doi.org/10.1111/tmi.13806

Objective Diabetes mellitus (DM) has been known to compromise tuberculosis (TB) treatment outcomes. Association data are limited for early hyperglycaemia detection and TB treatment outcomes. Thus, we assessed treatment outcomes including time to sput

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0381dc8d997c410dd185a7e8299d6e2c
https://doi.org/10.1111/tmi.13806

Whole genome sequencing-based drug resistance predictions of multidrug-resistant Mycobacterium tuberculosis isolates from Tanzania

Autor: Peter M. Mbelele, Christian Utpatel, Elingarami Sauli, Emmanuel A. Mpolya, Beatrice K. Mutayoba, Ivan Barilar, Viola Dreyer, Matthias Merker, Margaretha L. Sariko, Buliga M. Swema, Blandina T. Mmbaga, Jean Gratz, Kennedy K. Addo, Michel Pletschette, Stefan Niemann, Eric R. Houpt, Stellah G. Mpagama, Scott K. Heysell

Publikováno v: JAC-Antimicrobial Resistance. 4

Background Rifampicin- or multidrug-resistant (RR/MDR) Mycobacterium tuberculosis complex (MTBC) strains account for considerable morbidity and mortality globally. WGS-based prediction of drug resistance may guide clinical decisions, especially for t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c297160863b028ee13cd24d8d56c9e0c
https://doi.org/10.1093/jacamr/dlac042