Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Peter M Lansdorp"'
Autor:
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0268579 (2022)
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneup
Externí odkaz:
https://doaj.org/article/f584554feac24a5684cb7d0cfee58281
Autor:
Clémence Claussin, David Porubský, Diana CJ Spierings, Nancy Halsema, Stefan Rentas, Victor Guryev, Peter M Lansdorp, Michael Chang
Publikováno v:
eLife, Vol 6 (2017)
Homologous recombination involving sister chromatids is the most accurate, and thus most frequently used, form of recombination-mediated DNA repair. Despite its importance, sister chromatid recombination is not easily studied because it does not resu
Externí odkaz:
https://doaj.org/article/eacecb371933463c9ea5fe8a348952f9
Autor:
Floris Foijer, Lee A Albacker, Bjorn Bakker, Diana C Spierings, Ying Yue, Stephanie Z Xie, Stephanie Davis, Annegret Lutum-Jehle, Darin Takemoto, Brian Hare, Brinley Furey, Roderick T Bronson, Peter M Lansdorp, Allan Bradley, Peter K Sorger
Publikováno v:
eLife, Vol 6 (2017)
Chromosome instability (CIN) is deleterious to normal cells because of the burden of aneuploidy. However, most human solid tumors have an abnormal karyotype implying that gain and loss of chromosomes by cancer cells confers a selective advantage. CIN
Externí odkaz:
https://doaj.org/article/c794fbef09094ecd935bc32716b160f2
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002696 (2012)
Telomerase activity is readily detectable in extracts from human hematopoietic stem and progenitor cells, but appears unable to maintain telomere length with proliferation in vitro and with age in vivo. We performed a detailed study of the telomere l
Externí odkaz:
https://doaj.org/article/8fd8909cd6ee4ab2ab44dd0ee0473f6e
Autor:
Jonathan K Alder, Joy D Cogan, Andrew F Brown, Collin J Anderson, William E Lawson, Peter M Lansdorp, John A Phillips, James E Loyd, Julian J-L Chen, Mary Armanios
Publikováno v:
PLoS Genetics, Vol 7, Iss 3, p e1001352 (2011)
The telomerase reverse transcriptase synthesizes new telomeres onto chromosome ends by copying from a short template within its integral RNA component. During telomere synthesis, telomerase adds multiple short DNA repeats successively, a property kno
Externí odkaz:
https://doaj.org/article/f536a7f4cac4439391d5795fd2dca83c
Autor:
Rodrigo T Calado, Joshua A Regal, David E Kleiner, David S Schrump, Nathan R Peterson, Veronica Pons, Stephen J Chanock, Peter M Lansdorp, Neal S Young
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7926 (2009)
Telomerase is an enzyme specialized in maintaining telomere lengths in highly proliferative cells. Loss-of-function mutations cause critical telomere shortening and are associated with the bone marrow failure syndromes dyskeratosis congenita and apla
Externí odkaz:
https://doaj.org/article/cc31231c36fe46f8a65e5db5542ce313
Autor:
Timothy K. Turkalo, Antonio Maffia, Johannes J. Schabort, Samuel G. Regalado, Mital Bhakta, Marco Blanchette, Diana C. J. Spierings, Peter M. Lansdorp, Dirk Hockemeyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Mutations of ATRX are frequent in cancers that immortalize through the ALT (Alternative lengthening of telomeres) pathway. Here the authors show that ALT features are repressed in embryonic stem cells that lack ATRX but induced by continuous telomere
Externí odkaz:
https://doaj.org/article/c82b5c4319a248149ad833c8327f0f16
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107053- (2023)
Summary: How many times does a typical hematopoietic stem cell (HSC) divide to maintain a daily production of over 1011 blood cells over a human lifetime? It has been predicted that relatively few, slowly dividing HSCs occupy the top of the hematopoi
Externí odkaz:
https://doaj.org/article/c8c0b88c06ab4e59b00959509307cb70
Autor:
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
Externí odkaz:
https://doaj.org/article/6a7ed7595d2b4f12a042a1aaa930abc6
Autor:
Vahid Akbari, Vincent C.T. Hanlon, Kieran O’Neill, Louis Lefebvre, Kasmintan A. Schrader, Peter M. Lansdorp, Steven J.M. Jones
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100233- (2023)
Summary: Hundreds of loci in human genomes have alleles that are methylated differentially according to their parent of origin. These imprinted loci generally show little variation across tissues, individuals, and populations. We show that such loci
Externí odkaz:
https://doaj.org/article/94627485af9b4b7c9cc650f43d91c656