Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Peter M J Quinn"'
Autor:
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp 1-20 (2023)
Abstract Iron accumulation causes cell death and disrupts tissue functions, which necessitates chelation therapy to reduce iron overload. However, clinical utilization of deferoxamine (DFO), an iron chelator, has been documented to give rise to syste
Externí odkaz:
https://doaj.org/article/dad16b5228fa4f2aae01a11f4bb1e21e
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-20 (2020)
Abstract Mutations in the PTEN-induced kinase 1 (PINK1) and Parkin RBR E3 ubiquitin-protein ligase (PARKIN) genes are associated with familial forms of Parkinson’s disease (PD). PINK1, a protein kinase, and PARKIN, an E3 ubiquitin ligase, control t
Externí odkaz:
https://doaj.org/article/70c888ef25234b0f89e96f6c466f8d09
Publikováno v:
Frontiers in Genome Editing, Vol 3 (2021)
Inherited retinal diseases (IRDs) are chronic, hereditary disorders that lead to progressive degeneration of the retina. Disease etiology originates from a genetic mutation—inherited or de novo—with a majority of IRDs resulting from point mutatio
Externí odkaz:
https://doaj.org/article/42ebe1f21ae24412b673bd12851f342f
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1554 (2022)
Neurodegenerative diseases are characterized by the progressive degeneration of the neuronal cells and their networks, hampering the function of the central or peripheral nervous system [...]
Externí odkaz:
https://doaj.org/article/3672142ac2e64d7a8579075beeefde42
Autor:
Eugene Yu-Chuan Kang, Pei-Kang Liu, Yao-Tseng Wen, Peter M. J. Quinn, Sarah R. Levi, Nan-Kai Wang, Rong-Kung Tsai
Publikováno v:
Antioxidants, Vol 10, Iss 12, p 1948 (2021)
Ocular diseases associated with retinal ganglion cell (RGC) degeneration is the most common neurodegenerative disorder that causes irreversible blindness worldwide. It is characterized by visual field defects and progressive optic nerve atrophy. The
Externí odkaz:
https://doaj.org/article/c6ea998b9d814c7bbf06f78bbe5bd888
Autor:
Inês Ramos Rego, Daniela Silvério, Maria Isabel Eufrásio, Sandra Sofia Pinhanços, Bruna Lopes da Costa, José Teixeira, Hugo Fernandes, Yang Kong, Yao Li, Stephen H. Tsang, Paulo J. Oliveira, Rosa Fernandes, Peter M. J. Quinn, Paulo Fernando Santos, António Francisco Ambrósio, Celso Henrique Alves
Publikováno v:
Antioxidants
Volume 12
Issue 2
Pages: 381
Volume 12
Issue 2
Pages: 381
Age-related macular degeneration (AMD) is the leading cause of severe vision loss and blindness in elderly people worldwide. The damage to the retinal pigment epithelium (RPE) triggered by oxidative stress plays a central role in the onset and progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b17e891b84aa713235992c80bc6f62b
Autor:
Bruna Lopes da Costa, Masha Kolesnikova, Sarah R. Levi, Thiago Cabral, Stephen H. Tsang, Irene H. Maumenee, Peter M. J. Quinn
Publikováno v:
Biomedicines
Volume 11
Issue 2
Pages: 385
Volume 11
Issue 2
Pages: 385
Mutations in the Crumbs homolog 1 (CRB1) gene lead to severe inherited retinal dystrophies (IRDs), accounting for nearly 80,000 cases worldwide. To date, there is no therapeutic option for patients suffering from CRB1-IRDs. Therefore, it is of great
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ef01c34c2e6d803e73c4478449056d
Autor:
Yang Kong, Pei‐Kang Liu, Yao Li, Nicholas D Nolan, Peter M J Quinn, Chun‐Wei Hsu, Laura A Jenny, Jin Zhao, Xuan Cui, Ya‐Ju Chang, Katherine J Wert, Janet R Sparrow, Nan‐Kai Wang, Stephen H Tsang
Publikováno v:
EMBO Molecular Medicine. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b30536e1b0ca6c930547c539d57d3397
https://doi.org/10.15252/emmm.202216525
https://doi.org/10.15252/emmm.202216525
Autor:
Amy, Tso, Bruna Lopes, da Costa, Alexandra, Fehnel, Sarah R, Levi, Laura A, Jenny, Sara D, Ragi, Yao, Li, Peter M J, Quinn
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2560
Human retinal organoids derived from induced pluripotent stem cells (iPSCs) serve as a promising preclinical model for testing the safety and efficacy of viral gene therapy. Retinal organoids recapitulate the stratified multilayered epithelium struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92e12c11c91778b9a7301b60fd84102b
https://pubmed.ncbi.nlm.nih.gov/36481905
https://pubmed.ncbi.nlm.nih.gov/36481905
Autor:
Yi-Ting, Tsai, Bruna Lopes, da Costa, Nicholas D, Nolan, Salvatore Marco, Caruso, Laura A, Jenny, Sarah R, Levi, Stephen H, Tsang, Peter M J, Quinn
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2560
Inherited retinal diseases (IRDs) encompass a large heterogeneous group of rare blinding disorders whose etiology originates from mutations in the 280 genes identified to date. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0089fb7eb7a0ca5995cba570bd5b6f3c
https://pubmed.ncbi.nlm.nih.gov/36481907
https://pubmed.ncbi.nlm.nih.gov/36481907