Zobrazeno 1 - 10
of 329
pro vyhledávání: '"Peter M Glazer"'
Autor:
Erica B Schleifman, Nicole Ali McNeer, Andrew Jackson, Jennifer Yamtich, Michael A Brehm, Leonard D Shultz, Dale L Greiner, Priti Kumar, W Mark Saltzman, Peter M Glazer
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 2, Iss C (2013)
Biodegradable poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) encapsulating triplex-forming peptide nucleic acids (PNAs) and donor DNAs for recombination-mediated editing of the CCR5 gene were synthesized for delivery into human peripheral
Externí odkaz:
https://doaj.org/article/9d231e9a17ac4b9681ad99bc3e340c3f
Autor:
Rachael Putman, Adele S. Ricciardi, Kelly E. W. Carufe, Elias Quijano, Raman Bahal, Peter M. Glazer, W. Mark Saltzman
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Abstract Through preimplantation genetic diagnosis, genetic diseases can be detected during the early stages of embryogenesis, but effective treatments for many of these disorders are lacking. Gene editing could allow for correction of the underlying
Externí odkaz:
https://doaj.org/article/3edcc4c4f2cd451898388383fe6988a7
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-15 (2018)
Abstract Background Tumor hypoxia is an independent prognostic factor associated with poor patient survival. Emerging evidence suggests that hypoxia can potentially maintain or enhance the stem cell phenotype of both normal stem cells and cancer cell
Externí odkaz:
https://doaj.org/article/72396f2f37d942949504511bd39646ab
Publikováno v:
The Journal of Biochemistry.
The DNA mismatch repair (MMR) proteins recognize and repair DNA base pair mismatches and insertions/deletions of DNA that have occurred during DNA replication. Additionally, they are involved in regulation of the DNA damage response, including cell c
Autor:
Joann B. Sweasy, Peter M. Glazer, Daniel Zelterman, Michelle DeVeaux, Elisa de Stanchina, Jane S. Merkel, Laura Abriola, Antonia A. Nemec
Resistance to cancer chemotherapies leads to deadly consequences, yet current research focuses only on the roles of somatically acquired mutations in this resistance. The mutational status of the germline is also likely to play a role in the way cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67b0524d92c261c79717b95e79436efc
https://doi.org/10.1158/1541-7786.c.6539953.v1
https://doi.org/10.1158/1541-7786.c.6539953.v1
Autor:
Peter M. Glazer, Donald M. Engelman, Raman Bahal, Stanley Oyaghire, Yanfeng Liu, Ha Pham, Alanna R. Kaplan
The development of therapeutic agents that specifically target cancer cells while sparing healthy tissue could be used to enhance the efficacy of cancer therapy without increasing its toxicity. Specific targeting of cancer cells can be achieved throu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::967456cd8df7460b32a0e570d7849ead
https://doi.org/10.1158/1541-7786.c.6541771
https://doi.org/10.1158/1541-7786.c.6541771
Autor:
Peter M. Glazer, Susan E. Scanlon
Hypoxia induces genomic instability through replication stress and dysregulation of vital DNA repair pathways. The Fanconi anemia (FA) proteins, FANCD2 and FANCI, are key members of a DNA repair pathway that responds to replicative stress, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c449982b283edb9357b48d2136092eb
https://doi.org/10.1158/1541-7786.c.6539725
https://doi.org/10.1158/1541-7786.c.6539725
Additional Data for Patient Derived Melanoma Cells and Luciferase Reporter Assays
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f0aeeca5183cb318dd4e9bcee6277ad
https://doi.org/10.1158/1541-7786.22513458
https://doi.org/10.1158/1541-7786.22513458
Autor:
Peter M. Glazer, Donald M. Engelman, Raman Bahal, Stanley Oyaghire, Yanfeng Liu, Ha Pham, Alanna R. Kaplan
Fig. S1: pHLIP-αKu80(γ) binds to the mouse Ku80 sequence. Fig. S2: Validation of tumor vs. stromal cell sorting in EMT6-GFP cells. Fig. S3: Partial suppression of Ku80 expression induces radiosensitivity in cultured cancer cells. Fig. S4: pHLIP-αK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4823823498c3d5b7335c0675f8a5ce6e
https://doi.org/10.1158/1541-7786.22517572.v1
https://doi.org/10.1158/1541-7786.22517572.v1
Autor:
Charles P. Hart, Mark D. Matteucci, Peter M. Glazer, Gregory C. Stachelek, Adam V. Patterson, Robert F. Anderson, Andrej Maroz, Christopher P. Guise, Alexandra M. Mowday, Xiaohong Cai, Jian-Xin Duan, Gustavo Lorente, Leslie Lan, Monica Banica, Deepthi Bhupathi, James W. Evans, Fanying Meng
TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug (HAP) of bromo-isophosphoramide mustard currently undergoing clinical evaluation. Here, we describe broad-spectrum activity, hypoxia-selective activation, and mechanism of action of TH-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1647daf3bd322e5dd347e898918fddfd
https://doi.org/10.1158/1535-7163.c.6535963
https://doi.org/10.1158/1535-7163.c.6535963