Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Peter Májek"'
Autor:
Ruochen Jia, Leon Kutzner, Anna Koren, Kathrin Runggatscher, Peter Májek, André C. Müller, Michael Schuster, Christoph Bock, Joanna I. Loizou, Stefan Kubicek, Robert Kralovics
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Abstract Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for s
Externí odkaz:
https://doaj.org/article/54762303e96048909580862ed50205e5
Autor:
Rick Conzemius, Yehudit Bergman, Peter Májek, Stephan Beisken, Shawna Lewis, Emily B. Jacobs, Pranita D. Tamma, Patricia J. Simner
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Whole-genome sequencing (WGS) enables the molecular characterization of bacterial pathogens. We compared the accuracy of the Illumina and Oxford Nanopore Technologies (ONT) sequencing platforms for the determination of AMR classes and antimicrobial s
Externí odkaz:
https://doaj.org/article/f83d6a54745843d9b0d3ec3980632196
Publikováno v:
Antibiotics, Vol 12, Iss 2, p 366 (2023)
Genomic antimicrobial susceptibility testing (AST) has been shown to be accurate for many pathogens and antimicrobials. However, these methods have not been systematically evaluated for clinical metagenomic data. We investigate the performance of in-
Externí odkaz:
https://doaj.org/article/07d222576b7b468ea1630bece8994a93
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)
Antimicrobial resistance prediction from whole genome sequencing data (WGS) is an emerging application of machine learning, promising to improve antimicrobial resistance surveillance and outbreak monitoring. Despite significant reductions in sequenci
Externí odkaz:
https://doaj.org/article/38eb5253b32c4e2a9cbbe73644fa5c97
Characterization of host proteins interacting with the lymphocytic choriomeningitis virus L protein.
Autor:
Kseniya Khamina, Alexander Lercher, Michael Caldera, Christopher Schliehe, Bojan Vilagos, Mehmet Sahin, Lindsay Kosack, Anannya Bhattacharya, Peter Májek, Alexey Stukalov, Roberto Sacco, Leo C James, Daniel D Pinschewer, Keiryn L Bennett, Jörg Menche, Andreas Bergthaler
Publikováno v:
PLoS Pathogens, Vol 13, Iss 12, p e1006758 (2017)
RNA-dependent RNA polymerases (RdRps) play a key role in the life cycle of RNA viruses and impact their immunobiology. The arenavirus lymphocytic choriomeningitis virus (LCMV) strain Clone 13 provides a benchmark model for studying chronic infection.
Externí odkaz:
https://doaj.org/article/61f6526a55ef46658467aab0a567e0fd
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 4, p e1000360 (2009)
Identification of pathways involved in the structural transitions of biomolecular systems is often complicated by the transient nature of the conformations visited across energy barriers and the multiplicity of paths accessible in the multidimensiona
Externí odkaz:
https://doaj.org/article/078c16ec544f43dc994d103fbd20e41d
Autor:
Peter Májek, Ruochen Jia, Michael Schuster, Leon Kutzner, Anna Koren, André C. Müller, Joanna I. Loizou, Robert Kralovics, Christoph Bock, Stefan Kubicek, Kathrin Runggatscher
Publikováno v:
Blood Cancer Journal, Vol 11, Iss 7, Pp 1-10 (2021)
Blood Cancer Journal
Blood Cancer Journal
Mutations of calreticulin (CALR) are the second most prevalent driver mutations in essential thrombocythemia and primary myelofibrosis. To identify potential targeted therapies for CALR mutated myeloproliferative neoplasms, we searched for small mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690b9719f3a946df57c8d2fde8f355f6
https://doaj.org/article/54762303e96048909580862ed50205e5
https://doaj.org/article/54762303e96048909580862ed50205e5
Autor:
Jelena Remetic, Michael Trauner, Alexander Lercher, Thierry Claudel, Lisa Sandner, Anna Ohradanova-Repic, Matarr Khan, Wilfried Ellmeier, Nicole Boucheron, Alexandra Franziska Gülich, Emina Halilbasic, Thomas Weichhart, Claudia D. Fuchs, Andreas Bergthaler, Patricia Hamminger, C. Viczenczova, Clemens Donner, Philipp Schatzlmaier, Daniela Hainberger, Peter Májek, Hubert Scharnagl, André C. Müller, Hannes Stockinger, Teresa Preglej, Ci Zhu, Shinya Sakaguchi, Marlis Alteneder, Tatjana Stojakovic, Hatoon Baazim
Publikováno v:
Journal of Hepatology
Background & Aims 24-Norursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid used to treat immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC), where dysregulated T cells including CD8+ T cells contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a2a087a9619684085961f43a94a6ac
http://europepmc.org/articles/PMC8522806
http://europepmc.org/articles/PMC8522806
Publikováno v:
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 13049
International Journal of Molecular Sciences, Vol 22, Iss 13049, p 13049 (2021)
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 13049, p 13049 (2021)
International Journal of Molecular Sciences
The prediction of antimicrobial resistance (AMR) based on genomic information can improve patient outcomes. Genetic mechanisms have been shown to explain AMR with accuracies in line with standard microbiology laboratory testing. To translate genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac2d4c455972896fe584e8d53f96af7
Autor:
Peter Májek, Mark Petronczki, Stefan Kubicek, Sandra Schick, Christoph Bock, Guido Boehmelt, Kathrin Runggatscher, Thomas Penz, Jörg Menche, André C. Müller, Anna Ringler, Christian Schmidl, André F. Rendeiro, Loan Vulliard, Katja Parapatics, Melanie Hinkel, Bernd Boidol
Publikováno v:
Nature Genetics
Nature genetics
Nature genetics
Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how these mostly loss-of-function mutations contribute to cancer dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7947f16604e1ec6ef80f13431c57a2c9
https://doi.org/10.1038/s41588-019-0477-9
https://doi.org/10.1038/s41588-019-0477-9