Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Peter M, Lansdorp"'
Autor:
Timothy K. Turkalo, Antonio Maffia, Johannes J. Schabort, Samuel G. Regalado, Mital Bhakta, Marco Blanchette, Diana C. J. Spierings, Peter M. Lansdorp, Dirk Hockemeyer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Mutations of ATRX are frequent in cancers that immortalize through the ALT (Alternative lengthening of telomeres) pathway. Here the authors show that ALT features are repressed in embryonic stem cells that lack ATRX but induced by continuous telomere
Externí odkaz:
https://doaj.org/article/c82b5c4319a248149ad833c8327f0f16
Autor:
Anne Margriet Heijink, Colin Stok, David Porubsky, Eleni Maria Manolika, Jurrian K. de Kanter, Yannick P. Kok, Marieke Everts, H. Rudolf de Boer, Anastasia Audrey, Femke J. Bakker, Elles Wierenga, Marcel Tijsterman, Victor Guryev, Diana C. J. Spierings, Puck Knipscheer, Ruben van Boxtel, Arnab Ray Chaudhuri, Peter M. Lansdorp, Marcel A. T. M. van Vugt
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Sister chromatid exchanges (SCEs) are considered to be products of homologous recombination repair. The authors show that SCEs can arise independently of homologous recombination due to processing of replication intermediates during mitosis.
Externí odkaz:
https://doaj.org/article/6a7ed7595d2b4f12a042a1aaa930abc6
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107053- (2023)
Summary: How many times does a typical hematopoietic stem cell (HSC) divide to maintain a daily production of over 1011 blood cells over a human lifetime? It has been predicted that relatively few, slowly dividing HSCs occupy the top of the hematopoi
Externí odkaz:
https://doaj.org/article/c8c0b88c06ab4e59b00959509307cb70
Autor:
Vahid Akbari, Vincent C.T. Hanlon, Kieran O’Neill, Louis Lefebvre, Kasmintan A. Schrader, Peter M. Lansdorp, Steven J.M. Jones
Publikováno v:
Cell Genomics, Vol 3, Iss 1, Pp 100233- (2023)
Summary: Hundreds of loci in human genomes have alleles that are methylated differentially according to their parent of origin. These imprinted loci generally show little variation across tissues, individuals, and populations. We show that such loci
Externí odkaz:
https://doaj.org/article/94627485af9b4b7c9cc650f43d91c656
Autor:
Vincent C. T. Hanlon, Carl-Adam Mattsson, Diana C. J. Spierings, Victor Guryev, Peter M. Lansdorp
Publikováno v:
BMC Genomics, Vol 22, Iss 1, Pp 1-8 (2021)
Abstract Background Single cell Strand-seq is a unique tool for the discovery and phasing of genomic inversions. Conventional methods to discover inversions with Strand-seq data are blind to known inversion locations, limiting their statistical power
Externí odkaz:
https://doaj.org/article/16deb8ca989d44d6a98c5d60ea29c201
Autor:
Dorine C Hintzen, Mar Soto, Michael Schubert, Bjorn Bakker, Diana C J Spierings, Karoly Szuhai, Peter M Lansdorp, Roel J C Kluin, Floris Foijer, René H Medema, Jonne A Raaijmakers
Publikováno v:
PLoS ONE, Vol 17, Iss 7, p e0268579 (2022)
Aneuploidy and chromosomal instability are both commonly found in cancer. Chromosomal instability leads to karyotype heterogeneity in tumors and is associated with therapy resistance, metastasis and poor prognosis. It has been hypothesized that aneup
Externí odkaz:
https://doaj.org/article/f584554feac24a5684cb7d0cfee58281
Autor:
Mark J. P. Chaisson, Ashley D. Sanders, Xuefang Zhao, Ankit Malhotra, David Porubsky, Tobias Rausch, Eugene J. Gardner, Oscar L. Rodriguez, Li Guo, Ryan L. Collins, Xian Fan, Jia Wen, Robert E. Handsaker, Susan Fairley, Zev N. Kronenberg, Xiangmeng Kong, Fereydoun Hormozdiari, Dillon Lee, Aaron M. Wenger, Alex R. Hastie, Danny Antaki, Thomas Anantharaman, Peter A. Audano, Harrison Brand, Stuart Cantsilieris, Han Cao, Eliza Cerveira, Chong Chen, Xintong Chen, Chen-Shan Chin, Zechen Chong, Nelson T. Chuang, Christine C. Lambert, Deanna M. Church, Laura Clarke, Andrew Farrell, Joey Flores, Timur Galeev, David U. Gorkin, Madhusudan Gujral, Victor Guryev, William Haynes Heaton, Jonas Korlach, Sushant Kumar, Jee Young Kwon, Ernest T. Lam, Jong Eun Lee, Joyce Lee, Wan-Ping Lee, Sau Peng Lee, Shantao Li, Patrick Marks, Karine Viaud-Martinez, Sascha Meiers, Katherine M. Munson, Fabio C. P. Navarro, Bradley J. Nelson, Conor Nodzak, Amina Noor, Sofia Kyriazopoulou-Panagiotopoulou, Andy W. C. Pang, Yunjiang Qiu, Gabriel Rosanio, Mallory Ryan, Adrian Stütz, Diana C. J. Spierings, Alistair Ward, AnneMarie E. Welch, Ming Xiao, Wei Xu, Chengsheng Zhang, Qihui Zhu, Xiangqun Zheng-Bradley, Ernesto Lowy, Sergei Yakneen, Steven McCarroll, Goo Jun, Li Ding, Chong Lek Koh, Bing Ren, Paul Flicek, Ken Chen, Mark B. Gerstein, Pui-Yan Kwok, Peter M. Lansdorp, Gabor T. Marth, Jonathan Sebat, Xinghua Shi, Ali Bashir, Kai Ye, Scott E. Devine, Michael E. Talkowski, Ryan E. Mills, Tobias Marschall, Jan O. Korbel, Evan E. Eichler, Charles Lee
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Structural variants (SVs) in human genomes contribute diversity and diseases. Here, the authors use a multi-platform strategy to generate haplotype-resolved SVs for three human parent–child trios.
Externí odkaz:
https://doaj.org/article/1bf8e1b79b09479e9b177f1082c620e1
Autor:
Niek van Wietmarschen, Sarra Merzouk, Nancy Halsema, Diana C. J. Spierings, Victor Guryev, Peter M. Lansdorp
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Bloom syndrome is characterized by high levels of sister chromatid exchanges (SCEs). Here, the authors use single-cell DNA template strand-sequencing to map SCEs in patient cells, and propose that the BLM helicase protects the genome against unwanted
Externí odkaz:
https://doaj.org/article/618abfc1bc384381bf8da07ccfc3f7a1
Autor:
Peter M. Lansdorp
Publikováno v:
Blood Advances, Vol 1, Iss 25, Pp 2467-2472 (2017)
Abstract: The importance of telomere length to human health, aging, and cancer continues to be underappreciated. This review examines some basics of telomere biology and relates how telomere function, telomerase activity, and mutations in TERC or TER
Externí odkaz:
https://doaj.org/article/b9f21dd5c18a4fd990d56072618a38b1
Autor:
David Porubsky, Shilpa Garg, Ashley D. Sanders, Jan O. Korbel, Victor Guryev, Peter M. Lansdorp, Tobias Marschall
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Haplotype information is important in investigating many biological phenomena. Here, Porubsky et al. combine Strand-seq with long-read or linked-read sequencing to obtain complete and genome-wide haplotypes of a single individual genome at manageable
Externí odkaz:
https://doaj.org/article/db0127d509434bd2b9aa41d8de8838bc