COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

Autor: Peter M. Edelbroek, Linda Holtman, Anton Pekcec, Jan A. Gorter, Eleonora Aronica, Heidrun Potschka, Erwin A. van Vliet, Guido Zibell, Juli Schlichtiger

Publikováno v: Neuropharmacology
Neuropharmacology, 58(2), 404-412. Elsevier
Neuropharmacology; Vol 58
Neuropharmacology, 58(2), 404-412. Elsevier Limited

Epileptic seizures drive expression of the blood-brain barrier efflux transporter P-glycoprotein via a glutamate/cyclooxygenase-2 mediated signalling pathway. Targeting this pathway may represent an innovative approach to control P-glycoprotein expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a651595d7008cde703c8c2d548c98aa0
https://hdl.handle.net/11245/1.313931

Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives

Autor: Dick Lindhout, Peter M. Edelbroek, Ilse Wegner, Saskia Bulk

Publikováno v: Neurology. 73:1388-1393

Objective: We prospectively evaluated the fluctuation of lamotrigine (LTG) clearance during the menstrual cycle. We also assessed the effect of postmenopausal status and investigated in detail the effect of oral contraceptives (OCs) on LTG clearance.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a91037f17b5fcc9c5007bc544fddb0b7
https://doi.org/10.1212/wnl.0b013e3181bd8295

Trauma, stress, and preconscious threat processing in patients with psychogenic nonepileptic seizures

Autor: Peter M. Edelbroek, Philip Spinhoven, Jarl Kuyk, Patricia Bakvis, W.A.M. Swinkels, Karin Roelofs

Publikováno v: Epilepsia, 50, 1001-1011

SUMMARY Purpose: Psychogenic nonepileptic seizures (PNES) have long been considered as paroxysmal dissociative symptoms characterized by an alteration of attentional functions caused by severe stress or trauma. Although interpersonal trauma is common

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76eaf112d10aadb2541dcfe9cc2e9fb1
https://doi.org/10.1111/j.1528-1167.2008.01862.x

Region-Specific Overexpression of P-glycoprotein at the Blood-Brain Barrier Affects Brain Uptake of Phenytoin in Epileptic Rats

Autor: E.A. van Vliet, Jan A. Gorter, S. Redeker, Wytse J. Wadman, Eleonora Aronica, R. A. Voskuyl, R. van Schaik, Peter M. Edelbroek

Publikováno v: Journal of pharmacology and experimental therapeutics, 322(1), 141-147. American Society for Pharmacology and Experimental Therapeutics
The Journal of Pharmacology and experimental Therapeutics, 322, 141-147. American Society for Pharmacology and Experimental Therapeutics

Recent studies have suggested that overexpression of the multidrug transporter P-glycoprotein (P-gp) in the hippocampal region leads to decreased levels of antiepileptic drugs and contributes to pharmacoresistance that occurs in a subset of epileptic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6abea19e538cf73231854a991abfb2a1
https://doi.org/10.1124/jpet.107.121178

Expression of multidrug transporters MRP1, MRP2, and BCRP shortly after status epilepticus, during the latent period, and in chronic epileptic rats

Autor: Erwin A. van Vliet, Jan A. Gorter, Peter M. Edelbroek, Eleonora Aronica, S. Redeker

Publikováno v: Epilepsia, 46(10), 1569-1580. Wiley-Blackwell
Epilepsia, 46, 1569-1580. Wiley-Blackwell

Purpose: Overexpression of multidrug transporters may play a role in the development of pharmacoresistance by decreasing extracellular drug levels in the brain. However, it is not known whether overexpression is due to an initial insult or evolves mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149e40715a5464534f355390bd1c659d
https://doi.org/10.1111/j.1528-1167.2005.00250.x