Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Peter Liuni"'
Autor:
Yang Gao, Baishan Jiang, Hellen Kim, Jianwei Che, Katherine Donovan, John Hatcher, Fidel Huerta, Nicholas Kwiatkowski, Yingpeng Liu, Peter Liuni, Rebecca J. Metivier, Vineeth Murali, Radosław Nowak, Tinghu Zhang, Eric Fischer, Nathanael Gray, Lyn Jones
Publikováno v:
Cancer Research. 83:3426-3426
Heterobifunctional degraders, known as proteolysis targeting chimeras (PROTACs), is an emerging modality for drug discovery, and theoretically possess catalytic mode-of-action, yet few studies have either confirmed or exploited this potential advanta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d53d5f7d4b37d34ab3ea19045ead6b4
https://doi.org/10.1158/1538-7445.am2023-3426
https://doi.org/10.1158/1538-7445.am2023-3426
Publikováno v:
Biotechnology journalREFERENCES. 17(2)
Background Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and production have enabled candidate mAbs to be identified at a rapidly increasing rate, resulti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5064a0b7b0b8836ef2c9e183cd00007a
https://pubmed.ncbi.nlm.nih.gov/34747565
https://pubmed.ncbi.nlm.nih.gov/34747565
Background: Epitope mapping is an increasingly important aspect of biotherapeutic and vaccine development. Recent advances in therapeutic antibody design and production has enabled candidate mAbs to be identified at a rapidly increasing rate resultin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::788bc68b785ba1c0eb523afe2cdb449e
https://doi.org/10.22541/au.162742356.68704724/v1
https://doi.org/10.22541/au.162742356.68704724/v1
Autor:
Shaolong Zhu, Peter Liuni, Bruce Carpick, D. Andrew James, Tricia Chen, Luciano Ettorre, Jason Szeto, Derek J. Wilson
Publikováno v:
Biochemistry. 58:646-656
The diphtheria toxoid (DT) antigen is one of the major components in pediatric and booster combination vaccines and is known to raise a protective humoral immune response upon vaccination. However, a structurally resolved analysis of diphtheria toxin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36f847edb6d75185efe75b958a1dbbc
https://doi.org/10.1021/acs.biochem.8b01123
https://doi.org/10.1021/acs.biochem.8b01123
Enzymes are involved in nearly all biological processes, catalyzing reactions with exceptional selectivity and efficiency. Knowledge of reaction mechanisms, whereby a substrate is converted to product through one or more intermediates, is essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ea78bb85c69ef83e4a20f969572eacb
https://doi.org/10.1039/9781788010399-00173
https://doi.org/10.1039/9781788010399-00173
Enzymes are involved in nearly all biological processes, catalyzing reactions with exceptional selectivity and efficiency. Knowledge of reaction mechanisms, whereby a substrate is converted to product through one or more intermediates, is essential f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a500058e439bcf501bbce60fd1ba983f
https://doi.org/10.1039/9781788010399-00197
https://doi.org/10.1039/9781788010399-00197
Publikováno v:
Journal of visualized experiments : JoVE. (122)
Intrinsically disordered proteins (IDPs) have long been a challenge to structural biologists due to their lack of stable secondary structure elements. Hydrogen-Deuterium Exchange (HDX) measured at rapid time scales is uniquely suited to detect struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0733a62a2ca2d67f609b3cfb687436b1
https://pubmed.ncbi.nlm.nih.gov/28448048
https://pubmed.ncbi.nlm.nih.gov/28448048
Autor:
Maren Heimhalt, Paul J. Berti, Murray S. Junop, Derek J. Wilson, Frederick To, Naresh Balachandran, Peter Liuni
Publikováno v:
Biochemistry. 55(48)
3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) synthase catalyzes the first step in the shikimate pathway. It catalyzes an aldol-like reaction of phosphoenolpyruvate (PEP) with erythrose 4-phosphate (E4P) to form DAHP. The kinetic mechanism was ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d9d615b3844d9674bf4505bbd0540
https://pubmed.ncbi.nlm.nih.gov/27933795
https://pubmed.ncbi.nlm.nih.gov/27933795
Publikováno v:
Analytical Chemistry. 85:3758-3764
Kinetic isotope effect (KIE) measurements are a powerful tool for studying enzyme mechanisms; they can provide insights into microscopic catalytic processes and even structural constraints for transition states. However, KIEs have not come into wides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f2adbe00932b51022eb4aaa992e0fca
https://doi.org/10.1021/ac400191t
https://doi.org/10.1021/ac400191t
Autor:
Sarah A. Kessans, Peter Liuni, Renwick C. J. Dobson, Derek J. Wilson, Shaolong Zhu, Fen Peng, Katherine A. Donovan
Pyruvate kinase catalyzes the final step in glycolysis and is allosterically regulated to control flux through the pathway. Two models are proposed to explain how Escherichia coli pyruvate kinase type 1 is allosterically regulated: the "domain rotati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58277e392a104c7fb6cae6c818fcc9db
https://europepmc.org/articles/PMC4861489/
https://europepmc.org/articles/PMC4861489/