Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Peter Lindblom"'
Autor:
Barbara A. Kruk, Robert Cain, Richard D. Gregg, Suresh B. Singh, Dong Chengguo, Peter Lindblom, Linghang Zhuang, Liu Zhijie, Ya-Jun Zheng, Gerard McGeehan, David A. Claremon, Yi Zhao, Colin M. Tice, Deepak S. Lala
Publikováno v:
Journal of Chemical Information and Modeling. 59:3422-3436
With the continuous progress in ultralarge virtual libraries which are readily accessible, it is of great interest to explore this large chemical space for hit identification and lead optimization using reliable structure-based approaches. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a73b16847a98bc03cc59e741adf50f8
https://doi.org/10.1021/acs.jcim.9b00198
https://doi.org/10.1021/acs.jcim.9b00198
Autor:
Zhijie, Liu, Suresh B, Singh, Yajun, Zheng, Peter, Lindblom, Colin, Tice, Chengguo, Dong, Linghang, Zhuang, Yi, Zhao, Barbara A, Kruk, Deepak, Lala, David A, Claremon, Gerard M, McGeehan, Richard D, Gregg, Robert, Cain
Publikováno v:
Journal of chemical information and modeling. 59(8)
With the continuous progress in ultralarge virtual libraries which are readily accessible, it is of great interest to explore this large chemical space for hit identification and lead optimization using reliable structure-based approaches. In this wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02680043df5ae93b7a037e1f619219f2
https://pubmed.ncbi.nlm.nih.gov/31355641
https://pubmed.ncbi.nlm.nih.gov/31355641
Autor:
Bradford S. Hamilton, Frank Himmelsbach, Barbara A. Kruk, Joan Guo, Gerard McGeehan, Peter Lindblom, Rong Guo, Colin M. Tice, Brian M. McKeever, Linghang Zhuang, David A. Claremon, Judith A. Johnson, Katerina Leftheris, Lamont Howard, Salvacion Cacatian, Heike Schauerte, Annette Schuler-Metz, Richard Gregg, Reshma Panemangalore, Deepak S. Lala, Paula Krosky, Zhenrong Xu, Yuri Bukhtiyarov, Suresh B. Singh, Yuanjie Ye, Yi Zhao, Wei Zhao, Shi Meng
Publikováno v:
Bioorganicmedicinal chemistry. 25(14)
A potent, in vivo efficacious 11β hydroxysteroid dehydrogenase type 1 (11β HSD1) inhibitor (11j) has been identified. Compound 11j inhibited 11β HSD1 activity in human adipocytes with an IC50 of 4.3nM and in primary human adipose tissue with an IC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307a3ef85dcc22b2889fcf6062c9a383
https://pubmed.ncbi.nlm.nih.gov/28528082
https://pubmed.ncbi.nlm.nih.gov/28528082
Autor:
Deepak S. Lala, Paula Krosky, Kerri Lipinski, Colin M. Tice, Ya-Jun Zheng, Lamont Howard, Richard Gregg, Paul B. Noto, Yi Zhao, Kristi Fan, David A. Claremon, Zhongren Wu, Andrew W. Hardy, Rebecca Van Orden, Jing Zhou, Gerard McGeehan, Joan Guo, Cheng-Guo Dong, Stephen D. Lotesta, Geeta Kandpal, Jun Shimada, Zhijie Liu, Katerina Leftheris, Shi Meng, Suresh B. Singh, Guozhou Chen, Linghang Zhuang, Brian M. McKeever, Peter Lindblom, Yuri Bukhtiyarov, Wei Zhao
Publikováno v:
Journal of medicinal chemistry. 59(7)
This article describes the application of Contour to the design and discovery of a novel, potent, orally efficacious liver X receptor β (LXRβ) agonist (17). Contour technology is a structure-based drug design platform that generates molecules using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72847825e5e910bcb4d0f464f422727e
https://pubmed.ncbi.nlm.nih.gov/26990539
https://pubmed.ncbi.nlm.nih.gov/26990539
Autor:
Kam-Chuen Jim, Peter Lindblom, David A. Claremon, Richard D. Gregg, Suresh B. Singh, Guosheng Wu, Zhijie Liu, Ishchenko Alexey
Publikováno v:
Journal of Chemical Information and Modeling. 52:2089-2097
It is well-known that the structure-based design approach has had a measurable impact on the drug discovery process in identifying novel and efficacious therapeutic agents for a variety of disease targets. The de novo design approach has inherent pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a7422d22e04e9bd676dc670d6b6286
https://doi.org/10.1021/ci200605k
https://doi.org/10.1021/ci200605k
Autor:
Peter Lindblom, Zhijie Liu, Suresh B. Singh, Richard Gregg, Kam-Chuen Jim, Baldwin John J, Guosheng Wu, David A. Claremon
Publikováno v:
Journal of molecular graphicsmodelling. 53
Contour ® is a computational structure-based drug design technology that grows drug-like molecules by assembling context sensitive fragments in well-defined binding pockets. The grown molecules are scored by a novel empirical scoring function develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8784151eb8c54183b0b958235bcd6d0
https://pubmed.ncbi.nlm.nih.gov/25123650
https://pubmed.ncbi.nlm.nih.gov/25123650
Autor:
Peter Lindblom
Publikováno v:
Analytica Chimica Acta. 380:353-361
The paper describes a new type of Echelle spectrograph system that utilises a gated interline CCD camera. The system, that contains no moving parts, records simultaneously 6000 time-resolved spectral channels in the range 200–1100 nm with a lowest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76b423a5e81c17e4db99f9bb6d16f2b6
https://doi.org/10.1016/s0003-2670(98)00474-7
https://doi.org/10.1016/s0003-2670(98)00474-7
Publikováno v:
Innovations in Biomolecular Modeling and Simulations ISBN: 9781849734622
Structure-based design has had a significant impact on the drug discovery process over the past two decades by identifying novel and efficacious molecules for a variety of therapeutic targets. Among the approaches used for structure-based drug design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a182d3386297c3dbe608f97ba12f2453
https://doi.org/10.1039/9781849735056-00265
https://doi.org/10.1039/9781849735056-00265
Publikováno v:
Journal of Physics B: Atomic, Molecular and Optical Physics. 27:5241-5250
Spectra emitted from N2- and O2-doped solid krypton and xenon have for the first time been studied using energetic alpha and proton beams generated by a cyclotron. The studies were made in the NIR, visible and UV wavelength regions. With nitrogen gas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d027cb322e25ac801ceb00c0464ad82c
https://doi.org/10.1088/0953-4075/27/21/016
https://doi.org/10.1088/0953-4075/27/21/016
Publikováno v:
Journal of Physics B: Atomic, Molecular and Optical Physics. 27:L525-L528
High pressure nitrogen targets excited by energetic alpha particles show dominant emission of the Gaydon-Herman green system (transition). Bands from the Herman IR transition are also observed. The bands appear at pressures up to 900 kPa and under ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c53939c91494843f462a8bac2bd6eeb1
https://doi.org/10.1088/0953-4075/27/16/004
https://doi.org/10.1088/0953-4075/27/16/004