Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Peter Lenárt"'
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Ondřej Vacek, Jana Pokludová, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody–drug conjugate targeting Trop2 were recently approved for cancer therapy, th
Externí odkaz:
https://doaj.org/article/ec7ff7a2fa694aecb1011c9f0a61909f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract All homoiothermic organisms are capable of maintaining a stable body temperature using various negative feedback mechanisms. However, current models cannot satisfactorily describe the thermal adaptation of homoiothermic living systems in a p
Externí odkaz:
https://doaj.org/article/4d760ba91dc045b3a7d11422f85cf95d
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Autor:
Klement Stojanovski, Ioana Gheorghe, Peter Lenart, Anne Lanjuin, William B. Mair, Benjamin D. Towbin
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we use live imaging of the pharynx of C. elegans to ask if and how organ size scaling
Externí odkaz:
https://doaj.org/article/e6717014b02749d18f8741ca8020ab56
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Genetic drift is a basic evolutionary principle describing random changes in allelic frequencies, with far-reaching consequences in various topics ranging from species conservation efforts to speciation. The conventional approach assumes tha
Externí odkaz:
https://doaj.org/article/46221d49a25447f19260399cc6d6b1b4
Publikováno v:
BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-11 (2021)
Abstract Background The pace of aging varies considerably in nature. The best-known explanation of the evolution of specific rates of aging is the Williams’ hypothesis suggesting that the aging rate should correlate with the level of extrinsic mort
Externí odkaz:
https://doaj.org/article/a78d4b0bbf2049449e7f3642d478ade8
Autor:
Natalia Wesolowska, Ivan Avilov, Pedro Machado, Celina Geiss, Hiroshi Kondo, Masashi Mori, Peter Lenart
Publikováno v:
eLife, Vol 9 (2020)
The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) that are stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated
Externí odkaz:
https://doaj.org/article/74385f3219b441b8b152dd61277bf0f5
Autor:
Johanna Bischof, Christoph A. Brand, Kálmán Somogyi, Imre Májer, Sarah Thome, Masashi Mori, Ulrich S. Schwarz, Péter Lénárt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Surface contraction waves (SCWs) are prominent shape changes coupled to cell cycle transitions in oocytes. Here the authors show that SCWs are patterned by the spatiotemporal integration of two conserved modules, cdk1-cyclinB for cell cycle regulatio
Externí odkaz:
https://doaj.org/article/abec266d937c4acfa74253dfd390e3c9
Autor:
Nils Klughammer, Johanna Bischof, Nikolas D Schnellbächer, Andrea Callegari, Péter Lénárt, Ulrich S Schwarz
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 11, p e1006588 (2018)
Cytoplasmic flows are an ubiquitous feature of biological systems, in particular in large cells, such as oocytes and eggs in early animal development. Here we show that cytoplasmic flows in starfish oocytes, which can be imaged well with transmission
Externí odkaz:
https://doaj.org/article/2c9775629a5542da85415b1b6ac6bbeb
Autor:
Filip Zlámal, Peter Lenart, Daniela Kuruczová, Tomáš Kalina, Gabriel de la Torre, Miguel A Ramallo, Julie Bienertová-Vašků
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205812 (2018)
While stress is a widely utilized concept, no direct methods facilitating its measurement are currently available. In our previous work we proposed stress entropic load (SEL) as a potential new marker of stress response in the human body. However, at
Externí odkaz:
https://doaj.org/article/2700451cd0b447acb332cad9239b86e7