Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Peter Leadlay"'
1
Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition
Autor: Guifa Zhai, Yan Zhu, Guo Sun, Fan Zhou, Zhou Hong, Chuan Dong, Peter Leadlay, Kui Hong, Zixin Deng, Fuling Zhou, Yuhui Sun
Exploring interactions among modules in modular polyketide synthase (PKS) is very important for understanding the overall biosynthetic process and for engineering PKS assembly-lines. Herein, we show that intermodule recognition between the enoylreduc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::90c4b25f78603cfab41a1a7986dd0e69
https://doi.org/10.21203/rs.3.rs-1721330/v1
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2
Enzyme-Catalysed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis
Autor: Oksana Bilyk, Finian Leeper, Marcio Vinicius Bertacine Dias, Peter Leadlay
A key step in the biosynthesis of numerous polyketides is the stereospecific formation of a spiroacetal (spiroketal). We report here that spiroacetal formation in the biosynthesis of the macrocyclic polyketides ossamycin and oligomycin involves catal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::406dbc095e9ff8c5becfb8cd9c960bcd
https://doi.org/10.26434/chemrxiv-2022-h4v7z
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3
Crystal structure of BtrK, a decarboxylase involved in the (S)-4-amino-2-hydroxybutyrate (AHBA) formation during butirosin biosynthesis
Autor: Laura A. Rivas Arenas, Fernanda C.R. de Paiva, Nicolas de O． Rossini, YanYan Li, Jonathan Spencer, Peter Leadlay, Marcio V.B. Dias
Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Butirosin is an aminoglycoside that has an (S)-4-amino-2-hydroxybutyrate (AHBA) moiety capable of preventing the attack of several aminoglycoside modifying enzymes. The biosynthesis and the attachment of the AHBA to the 2-deoxystreptamine (2-DOS) inv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44bdcad9fb9b38cc228f40a28d71fa6e
https://doi.org/10.1016/j.molstruc.2022.133576
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4
Draft Genome Sequence of the Fungus
Autor: Taícia Pacheco, Fill, Jéssica Fernanda, Baretta, Luiz Gonzaga Paula, de Almeida, Iran, Malavazi, Louise Teixeira, Cerdeira, Markiyan, Samborskyy, Ana Tereza Ribeiro, de Vasconcelos, Peter, Leadlay, Edson, Rodrigues-Filho
Publikováno v: Microbiology Resource Announcements
Penicillium brasilianum (strain LaBioMMi 136) has been reported to be a great producer of secondary metabolites and a source of enzymes of biotechnological interest. Here, we report the draft genome sequence of P. brasilianum (strain LaBioMMi 136), i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50043f1563bcbb03b0e1c41f2efa4c25
https://pubmed.ncbi.nlm.nih.gov/30533840
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5
Mammalian fatty acid synthase: closure on a textbook mechanism?
Autor: Peter, Leadlay, Abel, Baerga-Ortiz
Publikováno v: Chemistrybiology. 10(2)
Mammalian fatty acid synthase is a classic example of a chain-building multienzyme. A cornerstone of its mechanism has been the obligatory collaboration of two identical subunits, with fatty acyl intermediates transferring between them. Now, fresh ev
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bcfd0ffa973d4de24a5185042bb44e4
https://pubmed.ncbi.nlm.nih.gov/12618189
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