Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Peter Laslo"'
Autor:
Laslo, Peter
Errata sheet on front end-paper.
Includes bibliography (leaves 171-204).
xv, 204, [121] leaves : ill. (chiefly col.) ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Li
Includes bibliography (leaves 171-204).
xv, 204, [121] leaves : ill. (chiefly col.) ; 30 cm.
Title page, contents and abstract only. The complete thesis in print form is available from the University Li
Externí odkaz:
http://hdl.handle.net/2440/19307
Autor:
Henry King, Alastair Droop, Ewan E. Morrison, Ruth Morton, Susan C Short, Julie Higgins, Gary Shaw, Peter Laslo, B. da Silva, Euan S. Polson, Lynette Steele, Daniel Tams, Heather L. Martin, Matthew Adams, Heiko Wurdak, Darren C. Tomlinson, Sean E. Lawler, Marjorie Boissinot, Josie Hayes, Jacquelyn Bond, Thomas Ward
Publikováno v:
Oncogene
MicroRNAs play an important role in the regulation of mRNA translation and have therapeutic potential in cancer and other diseases. To profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (GBM), we performed
Autor:
Pavle Krsmanovic, Heidi Mocikova, Kamila Chramostova, Magdalena Klanova, Marie Trnkova, Michal Pesta, Peter Laslo, Robert Pytlik, Tomas Stopka, Marek Trneny, Vit Pospisil
Publikováno v:
Cancers; Volume 14; Issue 9; Pages: 2305
Lymphoma with secondary central nervous system (CNS) involvement represents one of the most aggressive malignancies, with poor prognosis and high mortality. New diagnostic tools for its early detection, response evaluation, and CNS relapse prediction
Autor:
Peter Laslo, David G. Kent, Edwin Chen, Joanna Baxter, Jeanne F Rivera, Hershna Patel, Emma L Burman, Sally A Boxall, Brian R. Jackson, Ann Mullally, Grace Boyd, Rachael Smyth, Ghadah Alameer, April Joy Baral, Anthony R. Green, Fatima Nadat
Publikováno v:
Blood Adv
Calreticulin (CALR) is mutated in the majority of JAK2/MPL-unmutated myeloproliferative neoplasms (MPNs). Mutant CALR (CALRdel52) exerts its effect by binding to the thrombopoietin receptor MPL to cause constitutive activation of JAK-STAT signaling.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c88bd78a01d6c569428b7041878c47a
https://www.repository.cam.ac.uk/handle/1810/319699
https://www.repository.cam.ac.uk/handle/1810/319699
Autor:
Thomas Ward, Heiko Wurdak, Barbara da Silva, Daniel Tams, Euan S. Polson, Sean E. Lawler, Jacquelyn Bond, Ewan E. Morrison, Ruth Morton, Julie Higgins, Darren C. Tomlinson, Josie Hayes, Susan C Short, Henry King, Peter Laslo, Heather L. Martin, Lynette Steele, Matthew Adams, Marjorie Boissinot, Alastair Droop
BackgroundMicroRNAs play an important role in the regulation of mRNA translation, and have therapeutic potential in cancer and other diseases.MethodsTo profile the landscape of microRNAs with significant cytotoxicity in the context of glioblastoma (G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1da0487a4579d34f8508c5faccc92ed2
Autor:
Peter Laslo, Pavle Krsmanovic, Kamila Chramostová, Vit Pospisil, Martin Vokurka, Tomas Stopka
Publikováno v:
Experimental Hematology. 76:S82
Precise levels of transcription factor PU.1 are critical for differentiation to distinct blood lineages, and even modest decreases leads to leukemogenesis. However, the mechanism of how target genes sense different PU.1 levels is unknown. To address
Autor:
Anna Jonasova, Krivjanska M, Marek Trneny, Monika Belickova, Emanuel Necas, Karina Vargova, Filipp Savvulidi, Nikola Curik, Hana Hájková, Petra Vlckova, Pospisil, Cedrik Haškovec, Pavel Burda, Tomas Stopka, Jaroslav Cermak, Peter Laslo
Publikováno v:
Leukemia. 26:1804-1811
Epigenetic 5-azacitidine (AZA) therapy of high-risk myelodysplastic syndromes (MDS) and acute myelogenous leukemia (AML) represents a promising, albeit not fully understood, approach. Hematopoietic transcription factor PU.1 is dynamically regulated b
Autor:
Karin Vargova, Emanuel Necas, Jana Rybarova, Tomas Stopka, Juraj Kokavec, Vit Pospisil, Filipp Savvulidi, Anna Jonasova, Peter Laslo, Jiri Zavadil
Publikováno v:
The EMBO Journal. 30:4450-4464
The oncogenic cluster miR-17-92 encodes seven related microRNAs that regulate cell proliferation, apoptosis and development. Expression of miR-17-92 cluster is decreased upon cell differentiation. Here, we report a novel mechanism of the regulation o
Publikováno v:
Seminars in Immunology. 20:228-235
Considerable progress is being achieved in the analysis of gene regulatory networks that direct cell fate decisions within the hematopoietic system. In addition to transcription factors that are pivotal for cell fate specification and commitment, rec
Autor:
Peter Laslo, Nicholas P. Raybould, Denise Greenwood, Christian Soeller, Mark B. Cannell, Noriyuki Hoya, Gary D. Housley, Refik Kanjhan, Daniel J. Jagger
Publikováno v:
The Journal of Physiology. 579:101-113
Ca2+ signalling is central to cochlear sensory hair cell physiology through its influence on sound transduction, membrane filter properties and neurotransmission. However, the mechanism for establishing Ca2+ homeostasis in these cells remains unresol