Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Peter L. Wigley"'
Polyadenylation of mRNA: minimal substrates and a requirement for the 2' hydroxyl of the U in AAUAAA
Publikováno v:
Molecular and Cellular Biology. 10:1705-1713
mRNA-specific polyadenylation can be assayed in vitro by using synthetic RNAs that end at or near the natural cleavage site. This reaction requires the highly conserved sequence AAUAAA. At least two distinct nuclear components, an AAUAAA specificity
Autor:
Peter J, Cowan, Trixie A, Shinkel, Nella, Fisicaro, James W, Godwin, Carmelo, Bernabéu, Nuria, Almendro, Carlos, Rius, Andrew J, Lonie, Mark B, Nottle, Peter L, Wigley, Kathy, Paizis, Martin J, Pearse, Anthony J F, d'Apice
Publikováno v:
Xenotransplantation. 10(3)
It is highly likely that successful pig-to-human xenotransplantation of vascularized organs will require genetic modification of the donor pig, and in particular of donor vascular endothelium. Promoters are generally tested in transgenic mice before
Autor:
Brian K. May, W.H. Elliott, Adrienne R. Day, Peter L. Wigley, Gopesh Srivastava, Deborah J. Maguire, Iain A. Borthwick
Publikováno v:
Nucleic Acids Research. 14:1379-1391
5-Aminolevulinate synthase, the first and rate-controlling enzyme of heme biosynthesis, is regulated in the liver by the end-product heme. To study this negative control mechanism, we have isolated the chicken gene for ALA-synthase and determined the
Publikováno v:
Journal of Molecular Biology. 181:449-452
Vectors containing the chicken H5 gene were micro-injected into the nucleus of Xenopus laevis oocytes. Transcription of the H5 gene was accurately initiated and H5 transcripts with discrete 3' termini were produced. H5 transcripts were not polyadenyl
Autor:
Peter L. Wigley, Julian R. E. Wells
Publikováno v:
Molecular and cellular biology. 7(10)
Nuclear extracts from chicken erythroid cells selectively stimulate transcription of the chicken histone H5 gene (and not of other chicken histone genes) after coinjection into frog oocytes. This effect is shown to involve an enhancerlike activity, a
Autor:
Cowan, Peter J.1,2, Shinkel, Trixie A.1, Fisicaro, Nella1, Godwin, James W.1, Bernabéu, Carmelo3, Almendro, Nuria3, Rius, Carlos3, Lonie, Andrew J.4, Nottle, Mark B.4, Wigley, Peter L.4, Paizis, Kathy1, Pearse, Martin J.1, d'apice, Anthony J. F.1,2
Publikováno v:
Xenotransplantation. May2003, Vol. 10 Issue 3, p223-231. 9p.
Autor:
Tearle, Rick G., Tange, Margaret J., Zannettino, Zara L., Katerelos, Marina, Shinkel, Trixie A., Van Denderen, Bryce J.w., Lonie, Andrew J., Lyons, Ian, Nottle, Mark B., Cox, Timothy, Becker, Christiane, Peura, Anita M., Wigley, Peter L., Crawford, Robert J., Robins, Allan J., Pearse, Martin J., D'apice, Anthony J.f.
Publikováno v:
Transplantation; Jan1996, Vol. 61 Issue 1, p13-19, 7p
Autor:
David Hamilton
A History of Organ Transplantation is a comprehensive and ambitious exploration of transplant surgery—which, surprisingly, is one of the longest continuous medical endeavors in history. Moreover, no other medical enterprise has had so many multiple