Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Peter L Freddolino"'
Autor:
Hayeon Sung, Anoumid Vaziri, Daniel Wilinski, Riley KR Woerner, Peter L Freddolino, Monica Dus
Publikováno v:
eLife, Vol 12 (2023)
Diet profoundly influences brain physiology, but how metabolic information is transmuted into neural activity and behavior changes remains elusive. Here, we show that the metabolic enzyme O-GlcNAc Transferase (OGT) moonlights on the chromatin of the
Externí odkaz:
https://doaj.org/article/76b83b9ae22541ebb6a83c7482031a66
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010456 (2022)
Thymidine starvation causes rapid cell death. This enigmatic process known as thymineless death (TLD) is the underlying killing mechanism of diverse antimicrobial and antineoplastic drugs. Despite decades of investigation, we still lack a mechanistic
Externí odkaz:
https://doaj.org/article/16d200b5e270423ea619cdaa23ce2aea
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001557 (2022)
[This corrects the article DOI: 10.1371/journal.pbio.3001306.].
Externí odkaz:
https://doaj.org/article/43058f06522d48b1a91540d47578ab90
Publikováno v:
PLoS Biology, Vol 19, Iss 6, p e3001306 (2021)
Free-living bacteria adapt to environmental change by reprogramming gene expression through precise interactions of hundreds of DNA-binding proteins. A predictive understanding of bacterial physiology requires us to globally monitor all such protein-
Externí odkaz:
https://doaj.org/article/e3e348b3b0ed421ea97fd83f4a150a19
Publikováno v:
eLife, Vol 7 (2018)
Cells adapt to familiar changes in their environment by activating predefined regulatory programs that establish adaptive gene expression states. These hard-wired pathways, however, may be inadequate for adaptation to environments never encountered b
Externí odkaz:
https://doaj.org/article/1ab6927a0ac840be9988164ca8608d91
Autor:
Alison K Hottes, Peter L Freddolino, Anupama Khare, Zachary N Donnell, Julia C Liu, Saeed Tavazoie
Publikováno v:
PLoS Genetics, Vol 9, Iss 7, p e1003617 (2013)
The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each species' native ecological niche. In a new environment, however, the same bacteria may grow poorly due
Externí odkaz:
https://doaj.org/article/2ac6d6e037ea4a3495bbf6d2b1ad9d85
Publikováno v:
PLoS Genetics, Vol 8, Iss 5, p e1002744 (2012)
Regulatory networks allow organisms to match adaptive behavior to the complex and dynamic contingencies of their native habitats. Upon a sudden transition to a novel environment, the mismatch between the native behavior and the new niche provides sel
Externí odkaz:
https://doaj.org/article/71ab55c11f1e4a4fba3d2104354ce8b3
Publikováno v:
PLoS ONE, Vol 5, Iss 4, p e9890 (2010)
Recent advances in computing technology have enabled microsecond long all-atom molecular dynamics (MD) simulations of biological systems. Methods that can distill the salient features of such large trajectories are now urgently needed. Conventional c
Externí odkaz:
https://doaj.org/article/d8d1e241d10247be927332af64491710
Autor:
Yi-Heng Zhu, Chengxin Zhang, Yan Liu, Gilbert S. Omenn, Peter L. Freddolino, Dong-Jun Yu, Yang Zhang
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:1013-1027
Gene Ontology (GO) has been widely used to annotate functions of genes and gene products. We proposed a new method, TripletGO, to deduce GO terms of protein-coding and non-coding genes, through the integration of four complementary pipelines built on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eff058287d2624a43e3b100d918d8e9
https://doi.org/10.1016/j.gpb.2022.03.001
https://doi.org/10.1016/j.gpb.2022.03.001
Autor:
Jeremy W. Schroeder, Rebecca L. Hurto, Justin R. Randall, Katherine J. Wozniak, Taylor A. Timko, Taylor M. Nye, Jue D. Wang, Peter L. Freddolino, Lyle A. Simmons
RNA:DNA hybrids such as R-loops affect genome integrity and DNA replication fork progression. The overall impacts of naturally occurring RNA:DNA hybrids on genome integrity, and the relative contributions of ribonucleases H to mitigating the negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738e2044ba2e737b5dfa157ff21de8cc
https://doi.org/10.1101/2023.05.08.539860
https://doi.org/10.1101/2023.05.08.539860
