Zobrazeno 1 - 10
of 393
pro vyhledávání: '"Peter L Carlen"'
Autor:
Adam C Gravitis, Krishram Sivendiran, Uilki Tufa, Katherine Zukotynski, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L Carlen, Berj L Bardakjian
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0298943 (2024)
ObjectiveApproximately 50 million people worldwide have epilepsy and 8-17% of the deaths in patients with epilepsy are attributed to sudden unexpected death in epilepsy (SUDEP). The goal of the present work was to establish a biomarker for SUDEP so t
Externí odkaz:
https://doaj.org/article/37d73454d5c846c8808b4f6daee8df2c
Autor:
Daniel J Steinberg, Srinivasarao Repudi, Afifa Saleem, Irina Kustanovich, Sergey Viukov, Baraa Abudiab, Ehud Banne, Muhammad Mahajnah, Jacob H Hanna, Shani Stern, Peter L Carlen, Rami I Aqeilan
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 8, Pp 1-20 (2021)
Abstract Developmental and epileptic encephalopathies (DEE) are a group of disorders associated with intractable seizures, brain development, and functional abnormalities, and in some cases, premature death. Pathogenic human germline biallelic mutati
Externí odkaz:
https://doaj.org/article/87977a9dce6149adbe8551e943f5992a
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0148110 (2016)
Oxygen-glucose deprivation (OGD) leads to depression of evoked synaptic transmission, for which the mechanisms remain unclear. We hypothesized that increased presynaptic [Ca2+]i during transient OGD contributes to the depression of evoked field excit
Externí odkaz:
https://doaj.org/article/d1a3bf325b384713a391d0ccec916164
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Enhanced gap junctional communication (GJC) between neurons is considered a major factor underlying the neuronal synchrony driving seizure activity. In addition, the hippocampal sharp wave ripple complexes, associated with learning and seizures, are
Externí odkaz:
https://doaj.org/article/130efd8cca684a569cd52d7bd837c259
Autor:
Margaret Maheandiran, Shanthini Mylvaganam, Chiping Wu, Youssef El-Hayek, Sonia Sugumar, Lili Hazrati, Martin del Campo, Adria Giacca, Liang Zhang, Peter L Carlen
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83168 (2013)
It is well accepted that insulin-induced hypoglycemia can result in seizures. However, the effects of the seizures, as well as possible treatment strategies, have yet to be elucidated, particularly in juvenile or insulin-dependent diabetes mellitus (
Externí odkaz:
https://doaj.org/article/d35699abeb734ae6aa08ae857a835e88
Autor:
Paige Whyte-Fagundes, Daria Taskina, Nickie Safarian, Christiane Zoidl, Peter L. Carlen, Logan W. Donaldson, Georg R. Zoidl
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
The Panx1a and Panx1b (pannexin) ATP release channels exhibit pro- and anti-convulsant effects, respectively, in a zebrafish model, providing further insight into the role of pannexins in seizure development.
Externí odkaz:
https://doaj.org/article/c069c6db042d434194c16d77fdf6fa83
Autor:
Marjan Rafiee, Kramay Patel, David M. Groppe, Danielle M. Andrade, Eduard Bercovici, Esther Bui, Peter L. Carlen, Aylin Reid, Peter Tai, Donald Weaver, Richard Wennberg, Taufik A. Valiante
Publikováno v:
Epilepsia Open, Vol 5, Iss 2, Pp 285-294 (2020)
Abstract Objective Epilepsy is one of the most common neurological disorders . Many individuals continue to have seizures despite medical and surgical treatments, suggesting adjunctive management strategies are required. Promising effects of daily li
Externí odkaz:
https://doaj.org/article/3f397f46946d4587a733480a4864aed6
Autor:
Adam C. Gravitis, Uilki Tufa, Katherine Zukotynski, David L. Streiner, Daniel Friedman, Juliana Laze, Yotin Chinvarun, Orrin Devinsky, Richard Wennberg, Peter L. Carlen, Berj L. Bardakjian
Publikováno v:
Frontiers in Neurology. 14
IntroductionPrevious case-control studies of sudden unexpected death in epilepsy (SUDEP) patients failed to identify ECG features (peri-ictal heart rate, heart rate variability, corrected QT interval, postictal heart rate recovery, and cardiac rhythm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79bbaa1ce92907184880b360b04f4c4d
https://doi.org/10.3389/fneur.2023.1147576
https://doi.org/10.3389/fneur.2023.1147576
Autor:
Han Yan, Sara Breitbart, Darcia Paul, Alfonso Fasano, Andres M. Lozano, Jürgen Germann, Suneil K. Kalia, Carolina Gorodetsky, Peter L. Carlen, Aaron Loh, George M. Ibrahim
Publikováno v:
Neuromodulation: Technology at the Neural Interface. 25:271-275
Objectives Programming deep brain stimulation (DBS) is still based on a trial-and-error approach, often becoming a time-consuming process for both treating physicians and patients. Several strategies have been proposed to streamline DBS programming,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac25d98fd06fb318d74116449a341263
https://doi.org/10.1111/ner.13520
https://doi.org/10.1111/ner.13520
Publikováno v:
Sleep. 46
Cross-frequency coupling (CFC) between theta and high-frequency oscillations (HFOs) is predominant during active wakefulness, REM sleep and behavioral and learning tasks in rodent hippocampus. Evidence suggests that these state-dependent CFCs are lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9bcd073560cc5e293e3ee84cedbdafd
https://doi.org/10.1093/sleep/zsad027
https://doi.org/10.1093/sleep/zsad027