Výsledky vyhledávání - "Peter L, Van Lent"

Akademický článek

CD64 as novel molecular imaging marker for the characterization of synovitis in rheumatoid arthritis

Autor: Wessel F. Theeuwes, Irene Di Ceglie, Daphne N. Dorst, Arjen B. Blom, Desiree L. Bos, Thomas Vogl, Sander W. Tas, Pilar Jimenez-Royo, Mats Bergstrom, Matthew Cleveland, Peter M. van der Kraan, Peter Laverman, Marije I. Koenders, Peter L. van Lent, Martijn H. J. van den Bosch

Publikováno v: Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-15 (2023)

Abstract Background Rheumatoid arthritis (RA) is one of the most prevalent and debilitating joint diseases worldwide. RA is characterized by synovial inflammation (synovitis), which is linked to the development of joint destruction. Magnetic resonanc

Externí odkaz: https://doaj.org/article/2aad6123f8ac4ee5adcf05a7f4fb72f2

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Akademický článek

Local inhibition of TGF-β1 signaling improves Th17/Treg balance but not joint pathology during experimental arthritis

Autor: Joyce Aarts, Arjan van Caam, Xinlai Chen, Renoud J. Marijnissen, Monique M. Helsen, Birgitte Walgreen, Elly L. Vitters, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Marije I. Koenders

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

Abstract TGF-β1 is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β1 as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. W

Externí odkaz: https://doaj.org/article/e56341f6fbb745499f284ebee7d9f397

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Akademický článek

The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis

Autor: Arjen B. Blom, Martijn H. van den Bosch, Esmeralda N. Blaney Davidson, Johannes Roth, Thomas Vogl, Fons A. van de Loo, Marije Koenders, Peter M. van der Kraan, Edwin J. Geven, Peter L. van Lent

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-15 (2020)

Abstract Background Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response d

Externí odkaz: https://doaj.org/article/0d3325c14e2f4f258d2c206fd533edb7

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Akademický článek

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis.

Autor: Debbie M Roeleveld, Renoud J Marijnissen, Birgitte Walgreen, Monique M Helsen, Liduine van den Bersselaar, Fons A van de Loo, Peter L van Lent, Peter M van der Kraan, Wim B van den Berg, Marije I Koenders

Publikováno v: PLoS ONE, Vol 12, Iss 2, p e0171757 (2017)

Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduc

Externí odkaz: https://doaj.org/article/78384ac380dc442c8a8468639da74800

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Akademický článek

Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation.

Autor: Wouter Hofkens, Rik Schelbergen, Gert Storm, Wim B van den Berg, Peter L van Lent

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e54016 (2013)

BACKGROUND: To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis. MATERIAL AND METHODS: Experimental arthritis (antigen

Externí odkaz: https://doaj.org/article/4ac0fe0b07424525b2a61d62bc5dafcc

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M-CSF priming of osteoclast precursors can cause osteoclastogenesis-insensitivity, which can be prevented and overcome on bone

Autor: Teun J, De Vries, Ton, Schoenmaker, David, Aerts, Lilyanne C, Grevers, Pedro P C, Souza, Kamran, Nazmi, Mark, van de Wiel, Bauke, Ylstra, Peter L Van, Lent, Pieter J M, Leenen, Vincent, Everts

Publikováno v: Journal of cellular physiology. 230(1)

Osteoclasts and macrophages share progenitors that must receive decisive lineage signals driving them into their respective differentiation routes. Macrophage colony stimulation factor M-CSF is a common factor; bone is likely the stimulus for osteocl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::eb038cb349e5731d9d6f26c181ea357e
https://pubmed.ncbi.nlm.nih.gov/24962140

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Toll-like receptor 2 controls acute immune complex-driven arthritis in mice by regulating the inhibitory Fcγ receptor IIB

Autor: Shahla, Abdollahi-Roodsaz, Marije I, Koenders, Birgitte, Walgreen, Judith, Bolscher, Monique M, Helsen, Liduine A, van den Bersselaar, Peter L, van Lent, Fons A J, van de Loo, Wim B, van den Berg

Publikováno v: Arthritis and rheumatism. 65(10)

Previous studies have demonstrated a protective role of Toll-like receptor 2 (TLR-2) and a proinflammatory function of TLR-4 during chronic T cell-driven arthritis. The involvement of TLRs in T cell-independent arthritic processes, however, remains u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::36fd03aae8d52b318258cfaac4657bf9
https://pubmed.ncbi.nlm.nih.gov/24022363

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Destructive arthritis in the absence of both FcgammaRI and FcgammaRIII

Autor: Peter, Boross, Peter L, van Lent, Javier, Martin-Ramirez, Jos, van der Kaa, Melissa H C M, Mulder, Jill W C, Claassens, Wim B, van den Berg, Victoria L, Arandhara, J Sjef, Verbeek

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 180(7)

Fc receptors for IgG (FcgammaR) have been implicated in the development of arthritis. However, the precise contribution of the individual FcgammaR to joint pathology is unclear. In this study, the role of the different FcgammaR was assessed both in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81e17c82d78fdd8559e400a5771909db
https://pubmed.ncbi.nlm.nih.gov/18354234

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