Výsledky vyhledávání - "Peter Kulmburg"

Cytokine gene transfer in cancer therapy

Autor: Beata Mezes, Peter Kulmburg, Roland Mertelsmann, Albrecht Lindemann, Andreas Mackensen, Lei Cao, Hendrik Veelken, Felicia M. Rosenthal

Publikováno v: Scopus-Elsevier

New strategies based on gene transfer technology are employed in cancer therapy. Cytokines are polypeptides involved in immunity and inflammation, and essentially control the magnitude of the immune response. Genetically modified tumor cells releasin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ac141537402065436d2252b3e9ee4c
https://doi.org/10.1002/stem.5530160831

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Pro-Inflammatory and T Cell Inhibitory Cytokines Are Secreted at High Levels in Tumor Cell Cultures of Human Renal Cell Carcinoma

Autor: Gabriele Köhler, I. Hentrich, Dirk Behringer, Michael Lahn, Albrecht Lindemann, David N. Iklé, Regina Kunzmann, Peter Kulmburg, Paul Fisch, Hendrik Veelken, Birgit Muschal, Heike Jesuiter

Publikováno v: European Urology. 35:70-80

The objectives of this study were to assess cytokine secretion in human renal cell carcinoma (RCC) and to identify cytokines contributing to the immunomodulatory effect of tumor cells.Cytokine secretion in the supernatant of primary tumor cell cultur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a7e51502f1db8bdd3822810e0b0488
https://doi.org/10.1159/000019821

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NTS influence on transgene expression from mono- and bicistronic plasmid vectors after lipofection in a human fibroblast cell line

Autor: Peter Kulmburg, Andreas Mackensen, C. Schmoor, Albrecht Lindemann, Hendrik Veelken, R H Mertelsmann, F. M. Rosenthal

Publikováno v: Journal of Molecular Medicine. 75:223-229

We evaluated the survival, transgene production, and copy numbers of integrated plasmid units per host genome after lipofection with mono- and bicistronic plasmid vectors in different cell lines and under various conditions. The addition of an integr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf6a0509ab1b4f1184157f4f285c1ad9
https://doi.org/10.1007/s001090050107

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A phase-I clinical study of autologous tumor cells plus interleukin-2-gene-transfected allogeneic fibroblasts as a vaccine in patients with cancer

Autor: Felicia M. Rosenthal, Andreas Mackensen, Albrecht Lindemann, J. Hasse, Gabriele Köhler, B Franke, W Schultze-Seemann, Hendrik Veelken, U Brennscheidt, D Becker, Peter Kulmburg, M Lahn, H Keller, E.H. Farthmann, Roland Mertelsmann

Publikováno v: International Journal of Cancer. 70:269-277

Tumor cells transfected to express immunostimulatory cytokines, or admixed with similarly modified bystander cells, are able to induce immune responses against unmodified tumor cells in animal models. For treatment of human patients, a vaccine compos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4494e0ea9f0208d900c565dd3175dbc
https://doi.org/10.1002/(sici)1097-0215(19970127)70:3<269::aid-ijc4>3.0.co

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Systemic Hematological Effects of Granulocyte Colony-Stimulating Factor Produced by Irradiated Gene-Transfected Fibroblasts

Autor: Roland Mertelsmann, Albrecht Lindemann, Gabriele Köhler, Reinhard Früh, Peter Kulmburg, Andreas Mackensen, Carolin Pfeifer, Hendrik Veelken, Felicia M. Rosenthal

Publikováno v: Scopus-Elsevier

Although long-term expression of therapeutic molecules is necessary for the treatment of permanent deficiencies, short-term expression of therapeutic molecules inducing local or systemic effects is preferable in clinical situations where temporary su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e81eaa8e94a10990002d69514fe5b46
https://doi.org/10.1089/hum.1996.7.17-2147

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Accelerated wound healing by in vivo application of keratinocytes overexpressing KGF

Autor: Guang Y. Wang, Peter Kulmburg, Alexander D. Bach, Ulrich Kneser, Stefan Schultze-Mosgau, Raymund E. Horch, Jing N. Huan, Harun Seyhan, Mark D. Jeschke, Sheng D. Ge, Steven Dooley, Jürgen Kopp, Kang Ying

Publikováno v: Molecular therapy : the journal of the American Society of Gene Therapy. 10(1)

Epidermal regeneration is a complex process, strongly influenced by growth factors, including keratinocyte growth factor (KGF). The objective of this study was to establish immortalized HaCaT keratinocytes and KMST-6-fibroblasts stably expressing KGF

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbf169e96e6328080b5655be3d1363c
https://pubmed.ncbi.nlm.nih.gov/15233945

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Enhancement of a constitutively active promoter for gene therapy by a positive feed-back transcriptional activator mechanism

Autor: Hendrik Veelken, Albrecht Lindemann, B Leutgeb, H.H. Fiebig, Peter Kulmburg, Andreas Mackensen

Publikováno v: Scopus-Elsevier

Success of gene replacement therapy depends on long-term, high level expression of the transgene. Gene therapy vectors incorporating a promoter of a constitutively active eukaryotic gene may allow long-term expression in vivo, but the expression leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb0b9972fd75637e07386ca1abb9a33
https://pubmed.ncbi.nlm.nih.gov/9857228

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Genetically Modified Fibroblasts-Fibrin-Glue-Suspension for in vivo Drug Delivery of Epidermal Growth Factor (EGF): A Surface Gene Therapy Model not only for Wounds

Autor: T. Dodic, Cao L, C. Andree, X. Y. Jiao, Peter Kulmburg, E. Tanczos, B. Flis, G. B. Stark, J. Kopp

Publikováno v: Biological Matrices and Tissue Reconstruction ISBN: 9783642643477

Gene transfer offers an attractive method for the localized and persistent active delivery of growth factors to healing wounds: Gene therapy allows the controlled modification of cells to secrete the continuous localized production of polypeptides in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74784d47c6b4528ef1e765f34b3323e
https://doi.org/10.1007/978-3-642-60309-9_6

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