Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Peter Krajcsi"'
Autor:
Robert Hermann, Peter Krajcsi, Markus Fluck, Annick Seithel-Keuth, Afrim Bytyqi, Andrew Galazka, Alain Munafo
Publikováno v:
Clinical Pharmacokinetics. 61:167-187
Cladribine is a nucleoside analog that is phosphorylated in its target cells (B and T-lymphocytes) to its active triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6cd2fe6e73e87495f734393ce868c0
https://doi.org/10.1007/s40262-021-01089-9
https://doi.org/10.1007/s40262-021-01089-9
Publikováno v:
Journal of veterinary pharmacology and therapeuticsREFERENCES.
Monepantel (MNP), a novel anthelmintic drug from amino-acetonitrile derivatives, is a substrate for breast cancer resistance protein (BCRP). BCRP-mediated milk secretion of drugs can be altered by isoflavones. In this study, we aimed to show how soy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::384f6826967e02ee8181228488a2f631
https://pubmed.ncbi.nlm.nih.gov/36448496
https://pubmed.ncbi.nlm.nih.gov/36448496
Autor:
Andrew Galazka, Peter Krajcsi, Alain Munafo, Markus Fluck, Annick Seithel-Keuth, Robert Hermann, Afrim Bytyqi
Publikováno v:
Clinical Pharmacokinetics
Cladribine is a nucleoside analog that is phosphorylated in its target cells (B- and T-lymphocytes) to its active adenosine triphosphate form (2-chlorodeoxyadenosine triphosphate). Cladribine tablets 10 mg (Mavenclad®) administered for up to 10 days
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de91223e03a7f87c1ca37b6d68eeaec5
http://europepmc.org/articles/PMC8613159
http://europepmc.org/articles/PMC8613159
Publikováno v:
Pharmaceutics
Pharmaceutics, Vol 13, Iss 899, p 899 (2021)
Pharmaceutics, Vol 13, Iss 899, p 899 (2021)
Background: Serum urate (SU) levels in primates are extraordinarily high among mammals. Urate is a Janus-faced molecule that acts physiologically as a protective antioxidant but provokes inflammation and gout when it precipitates at high concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::586944d5b0693de3b51b75bedcbafb5d
http://europepmc.org/articles/PMC8235739
http://europepmc.org/articles/PMC8235739
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 15:313-328
ABCG2 has a broad substrate specificity and is one of the most important efflux proteins modulating pharmacokinetics of drugs, nutrients and toxicokinetics of toxicants. ABCG2 is an important player in transporter-mediated drug-drug interactions (tDD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd39577d27b8a1349c05a4eff0d12e0
https://doi.org/10.1080/17425255.2019.1591373
https://doi.org/10.1080/17425255.2019.1591373
Autor:
Peter Krajcsi, Anita Kurunczi, Tamás Janáky, E. Kis, Gábor Kecskeméti, Judit Molnár, Zoltán Szabó, Zsolt Sáfár
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 156
BCRP / ABCG2 is a key determinant of pharmacokinetics of substrate drugs. Several BCRP substrates and inhibitors are of low passive permeability, and the vesicular transport assay works well in this permeability space. Membranes were prepared from BC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d538eca620fb9a29efbf93121d8d86b
https://pubmed.ncbi.nlm.nih.gov/33059043
https://pubmed.ncbi.nlm.nih.gov/33059043
Autor:
Teresa Heslop, Beáta Tóth, Neil R. Kitteringham, Erzsébet Beéry, Peter Krajcsi, Márton Jani, Mark Bayliss, B. Kevin Park, Richard J. Weaver
Publikováno v:
Toxicology in Vitro. 52:189-194
Human OATP1B1 is highly expressed at the basolateral membrane of the hepatocyte. It plays an important role in the sodium-independent transport of bile acids and bile salts and contributes to the systemic clearance of many drugs. In this study, the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50aeb02296ba142ea0b40ba76f8e365
https://doi.org/10.1016/j.tiv.2018.06.018
https://doi.org/10.1016/j.tiv.2018.06.018
Autor:
Imre Klebovich, Viktória Juhász, Peter Krajcsi, Bernadett Kalapos-Kovács, Pál Szabó, Balázs Magda, István Antal, Csilla Temesszentandrási-Ambrus
Publikováno v:
Phytotherapy Research. 32:1647-1650
The use and significance of baicalin, the main bioactive component found in Radix Scutellaria, have been on the rise due to its interesting pharmacological properties. Baicalin, a low passive permeability compound, is directly absorbed from the upper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61982f57da7cb80ae79edb75ff7a54e2
https://doi.org/10.1002/ptr.6095
https://doi.org/10.1002/ptr.6095
Autor:
Petra Pádár, Attila Csorba, Kitti Szabó, Zoltan Timar, Viktória Juhász, Zoltan Nagy, Joseph K. Zolnerciks, Peter Krajcsi, William Johnson, Erzsébet Beéry, Éva D. Molnár
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:165-171
The purpose of this study was to characterize the uptake of carnitine, the physiological substrate, and the uptake of 3-(2,2,2-trimethylhydrazinium)propionate, a consensus substrate by rat Octn2 and human OCTN2 transporters as well as to characterize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9ddc94751448b85d55aa38db21ffa6
https://doi.org/10.1016/j.dmpk.2016.08.005
https://doi.org/10.1016/j.dmpk.2016.08.005
Publikováno v:
Saturday, 15 June 2019.
Background: Multidrug resistance transporters (MDR-ABC transporters, namely MDR1, MRP1 and BCRP) play essential role in the homeostasis of a variety of endogenous molecules, proinflammatory mediators among them [1]. When the regulation of this phenom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0274c436a0b5ccfd564a74d748f09968
https://doi.org/10.1136/annrheumdis-2019-eular.5706
https://doi.org/10.1136/annrheumdis-2019-eular.5706