Výsledky vyhledávání - "Peter Korytko"

Save Your Maximum Tolerated Dose: How to Diagnose Procedure-Related Spinal Cord Lesions After Lumbar Intrathecal Bolus Administration of Oligonucleotides in Cynomolgus Monkeys

Autor: Magdalena Wozniak, Jorge Luft, Peter Korytko, F. Runge, Serge Zander, Lars Mecklenburg, Anne von Keutz, Florian Timo Ludwig, Betina Pajaziti, Annette Romeike, Sven Korte

Publikováno v: International Journal of Toxicology. 39:510-517

Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e5caab55e193558a555cfe058c512
https://doi.org/10.1177/1091581820951098

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Range of Neurological Signs in Cynomolgus Monkeys After Intrathecal Bolus Administration of Antisense Oligonucleotides

Autor: Daniela Smieja, Florian Timo Ludwig, F. Runge, Sven Korte, Peter Korytko, Lars Mecklenburg, Magdalena Wozniak

Publikováno v: International journal of toxicology. 39(6)

Intrathecal (IT) dosing (ie, injection into the subarachnoidal space at the lumbar region) is a common route of administration in cynomolgus monkey preclinical safety studies conducted for antisense oligonucleotides (ASO) that target central nervous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::032a7b141bfa328a0ed77a1a2a8b18b3
https://pubmed.ncbi.nlm.nih.gov/32794413

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