Výsledky vyhledávání - "Peter Kilfoil"

Cell therapy attenuates endothelial dysfunction in hypertensive rats with heart failure and preserved ejection fraction

Autor: Geoffrey de Couto, Thassio Mesquita, Xiaokang Wu, Alex Rajewski, Feng Huang, Akbarshakh Akhmerov, Na Na, Di Wu, Yizhou Wang, Liang Li, My Tran, Peter Kilfoil, Eugenio Cingolani, Eduardo Marbán

Publikováno v: American journal of physiology. Heart and circulatory physiology. 323(5)

Heart failure with preserved ejection fraction (HFpEF) is defined by increased left ventricular (LV) stiffness, impaired vascular compliance, and fibrosis. Although systemic inflammation, driven by comorbidities, has been proposed to play a key role,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8832396b7aff28cf0b09afdaf75e81
https://pubmed.ncbi.nlm.nih.gov/36083797

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Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk - One pharma's experience and perspective

Autor: Eric D, Watt, Tiffany, Lee, Shuyun Lily, Feng, Peter, Kilfoil, David, Ackley, Christopher, Keefer, Todd, Wisialowski, Stephen, Jenkinson

Publikováno v: Journal of Pharmacological and Toxicological Methods. 118:107213

The use of high throughput patch clamp profiling to determine mixed ion channel-mediated arrhythmia risk was assessed using profiling data generated using proprietary internal and clinical reference compounds. We define the reproducibility of the pla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16565e459dea8ca183651ac33c68617a
https://doi.org/10.1016/j.vascn.2022.107213

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Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters

Autor: Stephen Jenkinson, Dingzhou Li, David J. MacEwan, Peter Kilfoil, Eric D. Watt, Derek J. Leishman, Parveen Sharma, Tiffany Lee, Asser Bassyouni, Shuyun Lily Feng

Publikováno v: European Journal of Pharmacology

Human induced pluripotent stem cell derived cardiomyocytes (hIPSC-CM's) play an increasingly important role in the safety profiling of candidate drugs. For such models to have utility a clear understanding of clinical translation is required. In the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354b5671ca62b0aeeb7522f5069bc852
https://pubmed.ncbi.nlm.nih.gov/34678241

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