Zobrazeno 1 - 10
of 119
pro vyhledávání: '"Peter Karran"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Potentially mutagenic DNA lesions induced by UVB (wavelengths 280–320 nm) are important risk factors for solar ultraviolet (UV) radiation-induced skin cancer. The carcinogenicity of the more abundant UVA (320–400 nm) is less well underst
Externí odkaz:
https://doaj.org/article/2d61f91494ce4b18ae6282880632edef
S1. Gel loading control for carbonyl visualization. S2. HaCaT cell survival as a function of CPDs. S3. NER in UVA-treated HeLa cells. S4. RPA overexpression in U2OS-RPA21 cells protects NER against inhibition by UVA. S5. The effect of IDH R132 inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7cc04cd4703cacfa95e316c5e36b2c1
https://doi.org/10.1158/1541-7786.22511008.v1
https://doi.org/10.1158/1541-7786.22511008.v1
Autor:
Peter Karran, Reto Brem
PDF file, 90K, Xanthine oxidase levels in cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c8c1b3ffb7a8a67bb1b8969d4d294b
https://doi.org/10.1158/0008-5472.22395354
https://doi.org/10.1158/0008-5472.22395354
Autor:
Francesca Marcon, Roberta Meschini, Egidio Iorio, Simonetta Palleschi, Gabriele De Luca, Ester Siniscalchi, Luigi Conti, Mattea Chirico, Maria Elena Pisanu, Francesca De Battistis, Barbara Rossi, Anna Minoprio, Alessandro Giuliani, Peter Karran, Margherita Bignami
Publikováno v:
Aging cell. 21(7)
hMTH1 protects against mutation during oxidative stress. It degrades 8-oxodGTP to exclude potentially mutagenic oxidized guanine from DNA. hMTH1 expression is linked to ageing. Its downregulation in cultured cells accelerates RAS-induced senescence,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d4892d9a7711502d580b1f3a632f79
https://pubmed.ncbi.nlm.nih.gov/35670027
https://pubmed.ncbi.nlm.nih.gov/35670027
Publikováno v:
Journal of Proteome Research
Long wavelength ultraviolet radiation (UVA, 320–400 nm) interacts with chromophores present in human cells to induce reactive oxygen species (ROS) that damage both DNA and proteins. ROS levels are amplified, and the damaging effects of UVA are exac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91af0423d8e6ae126f62bcf687b667bc
https://doi.org/10.1021/acs.jproteome.6b00717
https://doi.org/10.1021/acs.jproteome.6b00717
Publikováno v:
Molecular Cancer Research. 14:612-622
The relationship between sun exposure and nonmelanoma skin cancer risk is well established. Solar UV (wavelength 280–400 nm) is firmly implicated in skin cancer development. Nucleotide excision repair (NER) protects against cancer by removing poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44ff9b3728e74918ea91de3fd059ace8
https://doi.org/10.1158/1541-7786.mcr-16-0053
https://doi.org/10.1158/1541-7786.mcr-16-0053
Autor:
Quentin Gueranger, Annabel Larnicol-Fery, Peter Karran, Jean-Marc Egly, Matthew Peacock, Reto Brem, Peter Macpherson, Feng Li
Publikováno v:
Journal of Investigative Dermatology
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1187714730c123f55ea27cc7d1a012
Patients with hereditary non-polyposis colorectal cancer (HNPCC) have germ-line mutations in one of four DNA mismatch repair genes (hMSH2, hMLH1, hPMS1 and hPMS2). It is supposed that a single functional copy of these genes is sufficient for normal m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba6e6c868bebe55149d823f776bae33
https://ora.ox.ac.uk/objects/uuid:1918adf4-19d7-4095-b483-f047636fcf3e
https://ora.ox.ac.uk/objects/uuid:1918adf4-19d7-4095-b483-f047636fcf3e
Autor:
Peter Karran, N. R. Attard
Publikováno v:
Photochemical & Photobiological Sciences. 11:62-68
The thiopurines azathioprine, 6-mercaptopurine and 6-thioguanine (6-TG) are important medications for cancer and inflammatory disorders. They are also widely prescribed as immunosuppressants in organ transplant patients. Their metabolism results in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de40c290cf97de2c618aae4bed87cf93
https://doi.org/10.1039/c1pp05194f
https://doi.org/10.1039/c1pp05194f
Autor:
Peter Karran, Reto Brem
Publikováno v:
Cancer Research. 72:4787-4795
The thiopurines azathioprine and 6-mercaptopurine have been extensively prescribed as immunosuppressant and anticancer agents for several decades. A third member of the thiopurine family, 6-thioguanine (6-TG), has been used less widely. Although know
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82cde1384208759fc73b875030078474
https://doi.org/10.1158/0008-5472.can-12-1278
https://doi.org/10.1158/0008-5472.can-12-1278