Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Peter K. Stricklett"'
Publikováno v:
Cell Biochemistry and Biophysics. 61:643-650
Endothelin-1 (ET-1) is produced in unusually large amounts by the renal collecting duct and acts locally to control renal salt and water excretion and arterial pressure; disorders of collecting duct ET-1 activity can cause marked hypertension. The me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::474340d4384b8f3715ebc9010b8f0ab8
https://doi.org/10.1007/s12013-011-9250-0
https://doi.org/10.1007/s12013-011-9250-0
Publikováno v:
Journal of Biological Chemistry. 285:28520-28528
Collecting duct-derived ET-1 regulates salt excretion and blood pressure. We have reported the presence of an inner medullary collecting duct (IMCD)-specific enhancer region in the 5′-upstream ET-1 promoter (Strait, K. A., Stricklett, P. K., Kohan,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::369ad6325337e6195439e682008a70c4
https://doi.org/10.1074/jbc.m110.153189
https://doi.org/10.1074/jbc.m110.153189
Publikováno v:
American Journal of Physiology-Renal Physiology. 298:F859-F867
Little is known about collecting duct adenylyl cyclase (AC) isoforms or regulation in the mouse. We performed RT-PCR for AC isoforms 1–9 in microdissected cortical (CCD) and outer medullary (OMCD) and acutely isolated inner medullary (IMCD) collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e848a325a038cc34dcc4070c61376be
https://doi.org/10.1152/ajprenal.00109.2009
https://doi.org/10.1152/ajprenal.00109.2009
Autor:
Kalani L. Raphael, Donald E. Kohan, Klaus Piontek, Bradley C. Baird, Peter K. Stricklett, Kevin A. Strait, Gregory G. Germino
Publikováno v:
American Journal of Nephrology. 30:468-473
Background/Aims: Cystic epithelia in polycystic kidney disease display features similar to malignant cells. Thiazolidinediones have been shown to have anti-neoplastic properties, therefore we tested the hypothesis that pioglitazone reduces cyst forma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbe1bb1687c16fd577d70c29e8a6b7c4
https://doi.org/10.1159/000242432
https://doi.org/10.1159/000242432
Publikováno v:
American Journal of Physiology-Renal Physiology. 293:F601-F606
Collecting duct-derived endothelin-1 (ET-1) reduces blood pressure and inhibits Na and water reabsorption. Collecting duct ET-1 production is increased by volume expansion; however, the mechanism by which this occurs is unknown. We hypothesized that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07906cf8c54416dc05a0c3ce7ea8f612
https://doi.org/10.1152/ajprenal.00085.2007
https://doi.org/10.1152/ajprenal.00085.2007
Publikováno v:
The Journal of Infectious Diseases. 191:461-471
Brain injury in hemolytic-uremic syndrome (HUS) may be enhanced by inflammatory cytokine up-regulation of endothelial cell sensitivity to shigatoxin (Stx). The present study investigated whether inflammatory cytokine up-regulation of Stx toxicity cou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03e3d3d74e1304ad2c055c456253c33
https://doi.org/10.1086/427188
https://doi.org/10.1086/427188
Autor:
Raoul D. Nelson, Xiaohong Zhu, Peter K. Stricklett, Greg Chipman, Dennis Brown, Donald E. Kohan, Ludmilla Zharkikh, Sylvie Breton
Publikováno v:
American Journal of Physiology-Renal Physiology. 283:F1351-F1364
The purpose of this study is to develop transgenic mice with principal cell-specific expression of green fluorescent protein (GFP). After the cloning and sequencing of the mouse aquaporin-2 (AQP2) gene, 9.5 kb of the promoter were used to drive expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce9b57fbc7218ef3d6c28581eff1c75
https://doi.org/10.1152/ajprenal.0224.2001
https://doi.org/10.1152/ajprenal.0224.2001
Publikováno v:
The Journal of Infectious Diseases. 186:976-982
Mortality in postdiarrheal hemolytic-uremic syndrome (HUS) is associated with brain injury. Normally, brain cells are resistant to Shiga toxin (Stx), the putative pathogenic toxin in HUS. However, exposure of human brain endothelial cells (HBECs) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5361f244cb565188db8a20db22653e
https://doi.org/10.1086/344053
https://doi.org/10.1086/344053
Publikováno v:
Journal of the American Society of Nephrology. 13:2239-2245
Cellular injury in post-diarrheal hemolytic-uremic syndrome (D+HUS) is related to shigatoxin (Stx) binding to globotriaosylceramide (Gb3). High renal Gb3 expression may determine renal susceptibility in D+HUS; however, the molecular mechanism(s) resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd2f6bcac15257edaeea24fdc7aa188
https://doi.org/10.1097/01.asn.0000027873.85792.52
https://doi.org/10.1097/01.asn.0000027873.85792.52
Publikováno v:
Kidney International. 54:426-437
Cytotoxic effect of Shiga toxin-1 on human proximal tubule cells. Background Cytolytic Shiga toxins (Stx) are believed to be largely responsible for renal damage in post-diarrheal hemolytic-uremic syndrome (D+HUS). Despite the general belief that end
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b4aae88fca63e8a2aa7ada533aeb7df
https://doi.org/10.1046/j.1523-1755.1998.00015.x
https://doi.org/10.1046/j.1523-1755.1998.00015.x