Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Peter K Stys"'
Autor:
Tak-Ho Chu, Karen Cummins, Joseph S Sparling, Shigeki Tsutsui, Craig Brideau, K Peter R Nilsson, Jeffrey T Joseph, Peter K Stys
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0188218 (2017)
As an extension of the brain, the spinal cord has unique properties which could allow us to gain a better understanding of CNS pathology. The brain and cord share the same cellular components, yet the latter is simpler in cytoarchitecture and connect
Externí odkaz:
https://doaj.org/article/bffdf605e3444a2397089953b42387e7
Autor:
Peter K. Stys, Shigeki Tsutsui, Arie R. Gafson, Bert A. ‘t Hart, Shibeshih Belachew, Jeroen J. G. Geurts
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Multiple sclerosis (MS) is a frequently disabling neurological disorder characterized by symptoms, clinical signs and imaging abnormalities that typically fluctuate over time, affecting any level of the CNS. Prominent lymphocytic inflammation, many g
Externí odkaz:
https://doaj.org/article/c57060beacc04081b04c01066f7e86ab
Autor:
Laurent Ferron, Erika K. Harding, Maria A. Gandini, Craig Brideau, Peter K. Stys, Gerald W. Zamponi
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109973- (2024)
Summary: N- and P/Q-type voltage-gated Ca2+ channels are critical for synaptic transmission. While their expression is increased in the dorsal root ganglion (DRG) neuron cell bodies during neuropathic pain conditions, less is known about their synapt
Externí odkaz:
https://doaj.org/article/f7dd9b2885184647aa707d0d4f9e7033
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-12 (2022)
Abstract Protein misfolding is a prominent pathological hallmark of neurodegenerative disorders, including Alzheimer’s disease (AD). Studies have shown that the diversity of β sheet-rich protein deposits (such as amyloid β plaques and neurofibril
Externí odkaz:
https://doaj.org/article/aff37b1a6ea343a59fbcbc992b7c4b41
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-4 (2022)
Abstract As in neurons, CNS myelin expresses N-Methyl-D-Aspartate Receptors (NMDARs) that subserve physiological roles, but have the potential to induce injury to this vital element. Using 2-photon imaging of myelinic Ca in live ex vivo mouse optic n
Externí odkaz:
https://doaj.org/article/199b289fb7ee4988ba838224fe7e41a4
Autor:
Florian Hiess, Jinjing Yao, Zhenpeng Song, Bo Sun, Zizhen Zhang, Junting Huang, Lina Chen, Adam Institoris, John Paul Estillore, Ruiwu Wang, Henk E. D. J. ter Keurs, Peter K. Stys, Grant R. Gordon, Gerald W. Zamponi, Anutosh Ganguly, S. R. Wayne Chen
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-16 (2022)
A mouse model containing a GFP-tagged ryanodine receptor 2 (RyR2) has shed light on the precise subcellular localization of hippocampal RyR2 and mechanisms underlying neuronal excitability, learning, and memory.
Externí odkaz:
https://doaj.org/article/9b9b91a266df4b92bd4d0f52c3d1dc44
Autor:
Megan L. Morgan, Wulin Teo, Yda Hernandez, Craig Brideau, Karen Cummins, Hedwich F. Kuipers, Peter K. Stys
Publikováno v:
ASN Neuro, Vol 14 (2022)
The cuprizone (CPZ) model allows the study of the biochemical processes underlying nonautoimmune-mediated demyelination, remyelination, and chronic white matter disease progression. CPZ is a copper (Cu) chelator that chiefly causes oligodendrocyte ap
Externí odkaz:
https://doaj.org/article/4809e82acc134870b36d51565a61ae5e
Publikováno v:
Molecules, Vol 28, Iss 11, p 4483 (2023)
Amyloids are misfolded proteins that aggregate into fibrillar structures, the accumulation of which is associated with the pathogenesis of many neurodegenerative diseases, such as Alzheimer’s disease (AD). Early, sensitive detection of these misfol
Externí odkaz:
https://doaj.org/article/6193fe096a884ee8b6f72cf7bdd80e67
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 8, Iss 8, Pp 1709-1719 (2021)
Abstract The neuroinflammatory disease multiple sclerosis is driven by autoimmune pathology in the central nervous system. However, the trigger of the autoimmune pathogenic process is unknown. MS models in immunologically naïve, specific‐pathogen
Externí odkaz:
https://doaj.org/article/60bc53c765fe4325b8ff4803e9746646
Publikováno v:
Molecular Brain, Vol 14, Iss 1, Pp 1-4 (2021)
Abstract We have previously reported that cellular prion protein (PrPC) can down-regulate NMDA receptor activity and in a copper dependent manner. Here, we employed AAV9 to introduce murine cellular prion protein into mouse hippocampal neurons in pri
Externí odkaz:
https://doaj.org/article/8fa5b3c953204711a636cc7c05a3b137