Výsledky vyhledávání - "Peter K Harris"

Akademický článek

High-dimensional deconstruction of pancreatic cancer identifies tumor microenvironmental and developmental stemness features that predict survival

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-9 (2023)

Abstract Numerous cell states are known to comprise the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment (TME). However, the developmental stemness and co-occurrence of these cell states remain poorly defined. Here, we performed single-

Externí odkaz: https://doaj.org/article/903543a9685a4ed99c96f10cecf7b517

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Akademický článek

Urine cell-free DNA multi-omics to detect MRD and predict survival in bladder cancer patients

Publikováno v: npj Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2023)

Abstract Circulating tumor DNA (ctDNA) sensitivity remains subpar for molecular residual disease (MRD) detection in bladder cancer patients. To remedy this problem, we focused on the biofluid most proximal to the disease, urine, and analyzed urine tu

Externí odkaz: https://doaj.org/article/6c08dcfd52c5447997c27e3e554c3cca

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Akademický článek

Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study.

Publikováno v: PLoS Medicine, Vol 18, Iss 8, p e1003732 (2021)

BackgroundThe standard of care treatment for muscle-invasive bladder cancer (MIBC) is radical cystectomy, which is typically preceded by neoadjuvant chemotherapy. However, the inability to assess minimal residual disease (MRD) noninvasively limits ou

Externí odkaz: https://doaj.org/article/68ac59a93c0e4cf082db6dfecd686ee0

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Akademický článek

Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study.

Publikováno v: PLoS Medicine, Vol 18, Iss 8, p e1003734 (2021)

BackgroundThe leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. In the setting of N

Externí odkaz: https://doaj.org/article/c4e51b3f384e4d0d940d39076a2a352f

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Abstract 6670: Association between circulating CD4 memory T cell levels and severe immune-related adverse events in melanoma patients treated with immune checkpoint blockade

Autor: Abul Usmani, Noah Earland, Wubing Zhang, Peter K. Harris, Antonietta Bacchiocchi, Aishwarya Nene, David Y. Chen, Mario Sznol, Ruth Halaban, Aaron M. Newman, Aadel A. Chaudhuri

Publikováno v: Cancer Research. 83:6670-6670

Introduction: Severe immune-related adverse events (irAEs) occur in up to 60% of melanoma patients treated with immune checkpoint inhibitors (ICIs), causing substantial treatment-related morbidity and in the most severe cases, death. There is no clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2da498b86b9b50a8fe3c517dc70f8d8f
https://doi.org/10.1158/1538-7445.am2023-6670

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Abstract 3359: Sensitive detection of locoregional MRD after head and neck cancer surgery

Autor: Noah Earland, Ricardo J. Ramirez, Sophie P. Gerndt, Peter K. Harris, Andrew I. Hearn, Matthew Inkman, Jeffrey J. Szymanski, Nick Semenkovich, Benjamin M. Wahle, Zhongping Xu, Kevin Chen, Jin Zhang, Jose P. Zevallos, Aadel A. Chaudhuri

Publikováno v: Cancer Research. 83:3359-3359

Background: Plasma cell-free DNA (cfDNA) has low sensitivity to detect locoregional molecular residual disease (MRD) immediately after surgery for limited-stage head and neck cancer. To enhance locoregional MRD sensitivity, we utilize a novel bioflui

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1359687241d7c7b98f58973387415365
https://doi.org/10.1158/1538-7445.am2023-3359

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Abstract 997: Cell-free DNA fragmentomics distinguish between benign, pre-malignant and malignant peripheral nerve sheath tumors in neurofibromatosis type 1

Autor: Alex C. Pan, Russell Taylor Sundby, Jeffrey J. Szymanski, Paul A. Jones, Peter K. Harris, Aadel A. Chaudhuri, Angela C. Hirbe, Jack F. Shern

Publikováno v: Cancer Research. 83:997-997

Background: Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft tissue sarcomas that, in the setting of neurofibromatosis type 1 (NF1), arise within pre-malignant atypical neurofibroma (AN) and benign plexiform neurofibroma (PN). Ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f834c90462cb022a080796b6baea25f5
https://doi.org/10.1158/1538-7445.am2023-997

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