Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Peter John Whittle"'
Autor:
Kimberly A. Verdries, Martin Sanders, Michelle Vanase, Peter John Whittle, Jolanta Nowakowski, W. Stephen Faraci, Shawn D. Doran, Mark H. Stefaniak, James Baxter, Dane R. Liston, Robert B. Nelson, Steven D. Heck, Stevin H. Zorn, Michael A. Ashton, Charles E. Nolan, Robert A. Volkmann, Weimin Qian, John A. Lowe, Karen M. Ward, Celeste Johnson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2569-2572
The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57b946192c2fe3b394f0a5498cb73f
https://doi.org/10.1016/s0960-894x(99)00432-1
https://doi.org/10.1016/s0960-894x(99)00432-1
Autor:
Peter John Whittle, Tom L. Blundell
Publikováno v:
Annual Review of Biophysics and Biomolecular Structure. 23:349-375
Design cycles will undoubtedly play an increasingly important role in drug discovery in the coming years, as the amount of structural information on protein targets continues to rise. However, the traditional method of drug discovery, based upon rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23bf2ad3b326c873456ae769a6411bb0
https://doi.org/10.1146/annurev.bb.23.060194.002025
https://doi.org/10.1146/annurev.bb.23.060194.002025
Autor:
S.Edward Lee, Peter John Whittle, Stephen Hawrylik, Andrew M. Hemmings, James Merson, James E. Pitts, John P. Overington, Kathryn Shield, Andrew F. Wilderspin, S. P. Wood, Kieran Francis Geoghegan, Laurence H. Pearl, R. Lapatto, Peter M. Hobart, Tom L. Blundell, Dennis Edward Danley, Duncan J. H. Gaskin, Zhang-Yang Zhu
Publikováno v:
Retroviral Proteases ISBN: 9780333536124
HIV-1 proteinase processes its virally encoded polyproteins into mature structural proteins and enzymes that are essential for viral propagation. As a consequence the proteinase is an attractive target for prospective antiviral agents for the treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::344cecd549e9dbb42146cbca1fdbf640
https://doi.org/10.1007/978-1-349-11907-3_10
https://doi.org/10.1007/978-1-349-11907-3_10
Autor:
Shih-Jen Edward Lee, Steven J. Hawrylik, Stephen A. Wood, John P. Overington, Kathryn G. Scheld, Andrew M. Hemmings, Andrew F. Wilderspin, Dennis E. Danley, Peter John Whittle, R. Lapatto, Tom L. Blundell, James Merson, Peter M. Hobart, Kieran F. Geoghegan
Publikováno v:
Nature. 342:299-302
Knowledge of the tertiary structure of the proteinase from human immunodeficiency virus HIV-1 is important to the design of inhibitors that might possess antiviral activity and thus be useful in the treatment of AIDS. The conserved Asp-Thr/Ser-Gly se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8b9bc36bc5b414a3a2ed397a8096b9
https://doi.org/10.1038/342299a0
https://doi.org/10.1038/342299a0
Autor:
M. H. Tarbit, Peter John Whittle, Michael S. Marriott, Kenneth Richardson, Cooper Kelvin, Peter F. Troke
Publikováno v:
ChemInform. 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c049eb6dae4cc137fb676e2568ad6eda
https://doi.org/10.1002/chin.198926328
https://doi.org/10.1002/chin.198926328
Autor:
Michael S. Marriott, Kenneth Richardson, M. H. Tarbit, Cooper Kelvin, Peter John Whittle, Peter F. Troke
Publikováno v:
Annals of the New York Academy of Sciences. 544
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cae6fb6fb539df4b880518d5e5df0a
https://pubmed.ncbi.nlm.nih.gov/2850752
https://pubmed.ncbi.nlm.nih.gov/2850752