Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Peter J. Wookey"'
Autor:
Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton, Sebastian G. B. Furness
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
Abstract Background Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical importance. Results In thi
Externí odkaz:
https://doaj.org/article/14b30d0793574629978da705e838df9e
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Researchers are actively seeking novel targeted therapies for the brain tumour glioblastoma (GBM) as the mean survival is less than 15 months. Here we discuss the proposal that the calcitonin receptor (CT Receptor), expressed in 76–86% of patient b
Externí odkaz:
https://doaj.org/article/22bf9f7a3183427583119092b9336eaf
Publikováno v:
Cells, Vol 10, Iss 9, p 2347 (2021)
New strategies aimed at treatment of glioblastoma are frequently proposed to overcome poor prognosis. Recently, research has focused on glioma stem cells (GSCs), some quiescent, which drive expansion of glioblastoma and provide the complexity and het
Externí odkaz:
https://doaj.org/article/d647b105acea4898ab01823356ef559d
Autor:
Virginia Cappagli, Catarina Soares Potes, Luciana Bueno Ferreira, Catarina Tavares, Catarina Eloy, Rossella Elisei, Manuel Sobrinho-Simões, Peter J. Wookey, Paula Soares
Publikováno v:
PeerJ, Vol 5, p e3778 (2017)
Background Calcitonin expression is a well-established marker for medullary thyroid carcinoma (MTC); yet the role of calcitonin receptor (CTR), its seven-transmembrane G-protein coupled receptor, remains to be established in C-cells derived thyroid t
Externí odkaz:
https://doaj.org/article/30ce162084e548d2b5bb021c3be17aab
Publikováno v:
The Scientific World Journal, Vol 6, Pp 1642-1655 (2006)
Amylin is a polypeptide that is cosecreted with insulin from the β cells of the pancreas. Therefore, in states of diabetes in which the β-cell mass is largely depleted or dysfunctional, insulin and amylin secretion are also lost or dysregulated.Whi
Externí odkaz:
https://doaj.org/article/aa1a7dcdb2734d4f8d013fe4bd1c8a9c
Publikováno v:
The Scientific World Journal, Vol 3, Pp 163-175 (2003)
Amylin (islet amyloid polypeptide) is a peptide synthesized principally in the b-cells of the pancreatic islets together with insulin and has actions as a hormone, growth factor, and modifier of behavior. As a hormone, amylin acts to modify gastric m
Externí odkaz:
https://doaj.org/article/59a23c88b51d437ea90c5a8299f5be26
Autor:
Dana S. Hutchinson, Patrick M. Sexton, Denise Wootten, Caroline A. Hick, Peter J. Wookey, Sebastian G.B. Furness, Brett W. Stringer, Anna Ostrovskaya
Publikováno v:
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)
BMC Cancer
BMC Cancer
Background Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical importance. Results In this study w
Publikováno v:
Therapeutic Advances in Medical Oncology
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Therapeutic Advances in Medical Oncology, Vol 12 (2020)
Researchers are actively seeking novel targeted therapies for the brain tumour glioblastoma (GBM) as the mean survival is less than 15 months. Here we discuss the proposal that the calcitonin receptor (CT Receptor), expressed in 76–86% of patient b
Autor:
Shane Cheung, Pragya Gupta, David L Hare, Sebastian G.B. Furness, Lucas Bittencourt, Peter J. Wookey
Publikováno v:
F1000Research
The expression of the calcitonin receptor (CT Receptor) is widespread throughout the life cycle of mammals and in many diseases, and in these contexts the functions of the common isoforms is largely unknown. The relatively recent development of anti-
Publikováno v:
Cells
Cells, Vol 10, Iss 2347, p 2347 (2021)
Cells, Vol 10, Iss 2347, p 2347 (2021)
New strategies aimed at treatment of glioblastoma are frequently proposed to overcome poor prognosis. Recently, research has focused on glioma stem cells (GSCs), some quiescent, which drive expansion of glioblastoma and provide the complexity and het