Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Peter J. Thomford"'
Autor:
Gwendolyn D. Fate, Gregory L. Finch, Steven Bailey, Daniel Morton, Peter J. Thomford, Christopher Houle, Prashant R. Nambiar, Leland Wayne Dochterman
Publikováno v:
Toxicologic Pathology. 43:354-365
Administration of lersivirine, a nonnucleotide reverse transcriptase inhibitor, daily by oral gavage to Sprague-Dawley rats for up to 2 yr was associated with decreased survival, decreased body weights, and an increase in neoplasms and related prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e381add7cf3eecdcaeee1e9b43a2d9
https://doi.org/10.1177/0192623314544381
https://doi.org/10.1177/0192623314544381
Publikováno v:
Toxicology. 293:1-15
To investigate toxicity and neoplastic potential from chronic exposure to perfluorooctanesulfonate (PFOS), a two-year toxicity and cancer bioassay was conducted with potassium PFOS (K⁺ PFOS) in male and female Sprague Dawley rats via dietary exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30f23c8e1c5b14327b1dc12d8f101dea
https://doi.org/10.1016/j.tox.2012.01.003
https://doi.org/10.1016/j.tox.2012.01.003
Autor:
Peter J. Thomford, Robert L. Hall, George M. Shopp, Richard H. Bruner, Dorothy Bates Eppler, C. A. O'Neill, Anne M. Ryan, Kelly E. Hagler
Publikováno v:
Toxicologic Pathology. 27:78-86
Recombinant humanized antivascular endothelial growth factor (rhuMAbVEGF) is a monoclonal IgG, antibody that is being developed as an antiangiogenic agent for use in treating a variety of solid tumors. Preclinical safety studies included an immunohis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4fbba2e1efcddf2a6e67c3852a1540
https://doi.org/10.1177/019262339902700115
https://doi.org/10.1177/019262339902700115
Autor:
Richard J. Morales, Matthew J. Palazzolo, Peter J. Thomford, A.R. Disanto, Jeffrey S. Barrett, Eric M. Larsen
Publikováno v:
Biopharmaceutics & Drug Disposition. 18:165-184
The toxicology and toxicokinetics of a selegiline transdermal system (STS) were evaluated in a 3 month dog study of daily 24h applications of placebo 4, 8, or 12 STSs in 32 male and 32 female beagle dogs. Each STS delivered approximately 5 mg selegil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4020546a503c18ef717e0b6cbaa32749
https://doi.org/10.1002/(sici)1099-081x(199703)18:2<165::aid-bdd14>3.0.co
https://doi.org/10.1002/(sici)1099-081x(199703)18:2<165::aid-bdd14>3.0.co
Publikováno v:
Biology of Reproduction. 55:582-589
Five experiments were conducted to determine the minimal requirement for estradiol-171 (E 2) injections to induce either short pseudopregnancy (SPP) or long pseudopregnancy (LPP) in cycling gilts. In experiments 1 through 5, E 2 was injected i.m. on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d04101c8fca5b0c0aec8d42be2810f9e
https://doi.org/10.1095/biolreprod55.3.582
https://doi.org/10.1095/biolreprod55.3.582
Autor:
John L. Butenhoff, Patricia E. Noker, Reinhard Jung, Peter J. Thomford, Kris J Hansen, Paul M. Hinderliter, Gerald L. Kennedy, Gregory S. Gorman, Paul H. Lieder
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 82(2)
The pharmacokinetics of perfluorooctanoate (PFOA) in cynomolgus monkeys were studied in a six-month oral capsule dosing study of ammonium perfluorooctanoate (APFO) and in a single-dose iv study. In the oral study, samples of serum, urine, and feces w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2f9ca42c879dceefc38a05e84f0405
https://pubmed.ncbi.nlm.nih.gov/15470233
https://pubmed.ncbi.nlm.nih.gov/15470233
Autor:
John L. Butenhoff, Sandra R Eldridge, Andrew M. Seacat, Lisa A Clemen, Peter J. Thomford, Cliff Elcombe, Kris J Hansen
Publikováno v:
Toxicology. 183(1-3)
Perfluorooctanesulfonate (PFOS) is a widely disseminated persistent compound found at low (part-per-billion) concentrations in serum and liver samples from humans and fish-eating wildlife. This study investigated the hypotheses that early hepatocellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901ca64693b7956d05020b92a2349cd3
https://pubmed.ncbi.nlm.nih.gov/12504346
https://pubmed.ncbi.nlm.nih.gov/12504346
Autor:
Geary W. Olsen, John L. Butenhoff, Peter J. Thomford, Giovanni Costa, Reinhard Jung, Kristin Hansen, David G. Farrar, Gerald L. Kennedy, Cliff Elcombe, Paul H. Lieder, Hiroyuki Iwai
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 69(1)
Ammonium perfluorooctanoate (APFO) is a processing aid in the production of fluoropolymers that has been shown to have a long half-life in human blood. To understand the potential toxicological response of primates, groups of male cynomolgus monkeys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62003a8c98881c69d732b733d30fa4f8
https://pubmed.ncbi.nlm.nih.gov/12215680
https://pubmed.ncbi.nlm.nih.gov/12215680
Autor:
Andrew M. Seacat, Peter J. Thomford, Geary W. Olsen, John L. Butenhoff, Marvin T. Case, Kris J Hansen
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 68(1)
This study was conducted to determine the earliest measurable response of primates to low-level perfluorooctanesulfonate (PFOS) exposure and to provide information to reduce uncertainty in human health risk assessment. Groups of male and female monke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8796bf831f70d7922ede9e470b3cef43
https://pubmed.ncbi.nlm.nih.gov/12075127
https://pubmed.ncbi.nlm.nih.gov/12075127
Autor:
Andrew M. Seacat, Cliff Elcombe, Sandra R Eldridge, Kris J Hansen, Peter J. Thomford, Lisa A Clemen, John L. Butenhoff
Publikováno v:
Toxicology. 192:263-264
The publisher regrets that errors occurred in the printing of the above article. In the Abstract, the sentence “At 4 weeks, effects included decreased serum glucose and an equivocal (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8095952296136e8a04386c0e89f844b
https://doi.org/10.1016/s0300-483x(03)00335-4
https://doi.org/10.1016/s0300-483x(03)00335-4