Výsledky vyhledávání - "Peter J. Syapin"

Spatial Attention in Binge-Drinking and Moderate-Drinking College Students: An fMRI Investigation

Autor: Ronald C. Anderson, Michael W. O'Boyle, Karl Kashfi, Kareem Al-Khalil, Dan Fang, Peter J. Syapin, Jiancheng Hou

Publikováno v: Alcoholism Treatment Quarterly. 35:260-278

College-age binge drinking is considered a developmental disturbance that may give rise to unique treatment challenges. The present study used functional magnetic resonance imaging (fMRI) during the completion of a spatial Stroop task to compare brai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::19a1c103799f16ebdaf2c6290a4e0ad1
https://doi.org/10.1080/07347324.2017.1322429

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Effective Reduction in High Ethanol Drinking by Semisynthetic Tetracycline Derivatives

Autor: Yazan M. Al-Hasan, Jessica A. Groot, Peter J. Syapin, David R. M. Trotter, Joseph M. Martinez, David C. Curtis, Patrick C. Marquardt, Carol Baby, Clayton L. Allison, Matthew J. Scheible, Susan E. Bergeson, David S. Edwards, Jose Luis Redondo, Katy T. Nicholson, Ismael Segura-Ulate

Publikováno v: Alcoholism: Clinical and Experimental Research. 40:2482-2490

Background New pharmacotherapies to treat alcohol use disorders (AUD) are needed. Given the complex nature of AUD, there likely exist multiple novel drug targets. We, and others, have shown that the tetracycline drugs, minocycline and doxycycline, re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8bf7cb14c5efccf0f6459874198a934
https://doi.org/10.1111/acer.13253

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Bioinformatics Analyses Reveal Age-Specific Neuroimmune Modulation as a Target for Treatment of High Ethanol Drinking

Autor: Yukun Chen, Benjamin D. Colvard, Jonathan Nguyen, Rajiv G. Agrawal, Ryan J. Hogue, Ari E. Berman, Yazan M. Al-Hasan, Anna Kate Fowler, Patricia S. Levin, Peter J. Syapin, Yuri A. Blednov, Susan E. Bergeson, Oscar Velasquez, Aveline Hewetson, Scott R. Franklin, Chris Walz, Julie A. Owen

Publikováno v: Alcoholism: Clinical and Experimental Research. 38:428-437

Alcoholism is a complex trait involving the interaction of numerous biological and environmental factors. In the past several decades, researchers have convincingly elucidated that, for a disease of such complexity as alcoholism, no single molecular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15448687b1dade0961634c59008905a
https://doi.org/10.1111/acer.12288

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Effective Reduction of Acute Ethanol Withdrawal by the Tetracycline Derivative, Tigecycline, in Female and Male DBA/2J Mice

Autor: David S. Edwards, Jessica A. Groot, Deborah A. Finn, David C. Curtis, Joseph M. Martinez, Ashley N. Holmes, Clayton L. Allison, Patrick C. Marquardt, Susan E. Bergeson, Peter J. Syapin, David R. M. Trotter

Publikováno v: Alcoholism, clinical and experimental research. 40(12)

Background Alcohol use disorder (AUD) is a spectrum disorder characterized by mild to severe symptoms, including potential withdrawal signs upon cessation of consumption. Approximately five hundred thousand patients with AUD undergo clinically releva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83769e0fef19f211d3fbe947cd437d47
https://pubmed.ncbi.nlm.nih.gov/27862011

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Brain Damage and Alcohol Dependence: How One May Influence the Other

Autor: Peter J. Syapin

Publikováno v: Alcoholism Treatment Quarterly. 29:132-145

Alcohol dependence is associated with brain cell loss and other changes leading to brain damage. The issue of which comes first, damage then dependence or vice versa, has not been established. This article provides an overview of our understanding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ffbcc1d6e2e5d6a4a50c2979e8dc3dd0
https://doi.org/10.1080/07347324.2011.557985

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Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

Autor: Peter J. Syapin

Publikováno v: British Journal of Pharmacology. 155:623-640

Injury to the CNS elicits a host defense reaction that utilizes astrocytes, microglia, neurons and oligodendrocytes. Neuroinflammation is a major host defense mechanism designed to restore normal structure and function after CNS insult, but like othe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fe50b884d63003c872f59fc06b6eb0b4
https://doi.org/10.1038/bjp.2008.342

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Interactions of alcohol and nitric-oxide synthase in the brain

Autor: Peter J. Syapin, Randall L. Davis

Publikováno v: Brain Research Reviews. 49:494-504

Nitric oxide (NO) is an important molecule associated with both physiological and pathological brain events. Three separate genes encode for nitric-oxide synthase (NOS), the rate-limiting enzyme in NO production, all of which are expressed within bra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf8793a550c9b0d2f7ff5e3acb41d09
https://doi.org/10.1016/j.brainresrev.2005.01.008

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Alcohol Brain Damage and Neuroinflammation: Is There a Connection?

Autor: William F. Hickey, Peter J. Syapin, Cynthia J.M. Kane

Publikováno v: Alcoholism: Clinical & Experimental Research. 29:1080-1089

Many neurological disorders include a neuroinflammatory response in the central nervous system (CNS) that contributes to the pathogenesis and progression of the condition. However, the question of whether neuroinflammation plays a role in alcohol-ind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87e14cceb9f4d6d1be1321bf70369420
https://doi.org/10.1097/01.alc.0000167961.39176.e6

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Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: evidence for a transcriptional mechanism

Autor: Peter J. Syapin, Randall L. Davis

Publikováno v: Alcohol. 32:195-202

Astroglia are important in immunocompetence and response to injury within the CNS. Activated astroglia respond, in part, by expressing inducible nitric-oxide synthase (iNOS) and subsequent catalytic production of nitric oxide. Results from a previous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf93728141dd34ca9f9bdbbadc3a4421
https://doi.org/10.1016/j.alcohol.2004.01.006

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