Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Peter J. Stengel"'
1
Synthesis of Akt Inhibitor Ipatasertib. Part 1. Route Scouting and Early Process Development of a Challenging Cyclopentylpyrimidine Intermediate
Autor: Travis Remarchuk, Peter J. Stengel, Keith Lee Spencer, Nicholas C. Kallan, Shakya Sagar, Lane Jonathan W
Publikováno v: Organic Process Research & Development. 18:1641-1651
Herein, the route scouting and early process development of a key cyclopentylpyrimidine ketone intermediate toward the synthesis of Akt inhibitor Ipatasertib are described. Initial supplies of the intermediate were prepared through a method that comm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0274d4c2b15fe592fd9f445fc9297c3a
https://doi.org/10.1021/op500271w
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2
Synthesis of HIV Protease Inhibitor ABT-378 (Lopinavir)
Autor: Patel Ketan M, Jien-Heh J. Tien, Lawrence Kolaczkowski, Joseph B. Paterson, Arthur J. Cooper, and Peter J. Stengel, Jih-Hua Liu, Daniel J. Plata, Patricia A. Oliver-Shaffer, David A. Riley, Daniel A. Dickman, H. L. Sham, Eric J. Stoner, John E. Lallaman
Publikováno v: Organic Process Research & Development. 4:264-269
A large scale process for the synthesis of HIV protease inhibitor candidate ABT-378 has been developed which utilizes an intermediate common to the synthesis of ritonavir, Abbott's first generation compound. The synthesis relies on the sequential acy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83ee1d1cf451e53c6ebab1944c57cf71
https://doi.org/10.1021/op990202j
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3
Synthesis of ABT-378, an HIV Protease Inhibitor Candidate: Avoiding the Use of Carbodiimides in a Difficult Peptide Coupling
Autor: Eric J. Stoner, Arthur J. Cooper, and Peter J. Stengel
Publikováno v: Organic Process Research & Development. 3:145-148
An alternative to carbodiimide-mediated peptide coupling protocols has been developed for a carboxylic acid prone to decomposition by polymerization. This method, involving the in situ generation of an acyl imidazolide, has been applied to the prepar
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2d2cae35a54119677928f0c18e64a756
https://doi.org/10.1021/op980214p
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4
Reduction of 2-acylaziridines by samarium(II) iodide. An efficient and regioselective route to β-amino carbonyl compounds
Autor: Gary A. Molander, Peter J. Stengel
Publikováno v: Tetrahedron. 53:8887-8912
A convenient method for the reduction of 2-acylaziridines, aziridine-2-carboxylates and aziridine-2-carboxamides is described. The reduction of all of the substrates examined was extremely rapid and highly regioselective, giving rise to β-amino carb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7c3065bb01436a48a9397a7898337fac
https://doi.org/10.1016/s0040-4020(97)90399-9
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5
Synthesis of methyl-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate via a Hofmann rearrangement utilizing trichloroisocyanuric acid as an oxidant
Autor: Zackary D. Crane, Tarek Sammakia, Paul J. Nichols, Peter J. Stengel
Publikováno v: The Journal of organic chemistry. 76(1)
A trichloroisocyanuric acid (TCCA) mediated Hofmann rearrangement was utilized to synthesize methyl-1-(tert-butoxycarbonylamino)-2-vinylcyclopropanecarboxylate. A variety of functional groups are tolerated in this reaction including vinyl, cyclopropy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1819318b47f54376f6c0018b49ecd0
https://pubmed.ncbi.nlm.nih.gov/21133382
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8
ChemInform Abstract: Reduction of 2-Acylaziridines by Samarium(II) Iodide. An Efficient and Regioselective Route to β-Amino Carbonyl Compounds
Autor: Peter J. Stengel, Gary A. Molander
Publikováno v: ChemInform. 28
A convenient method for the reduction of 2-acylaziridines, aziridine-2-carboxylates and aziridine-2-carboxamides is described. The reduction of all of the substrates examined was extremely rapid and highly regioselective, giving rise to β-amino carb
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca03c1cd2e93cca0e5625d45a235fbc
https://doi.org/10.1002/chin.199743113
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9
cis-2-Tri-n-butylstannylvinyl cuprates: a new synthon for the cis-1,2-ethene dianion
Autor: Joseph P. Marino, Mark V.M. Emonds, Peter J. Stengel, Fabio Simonelli, Alfredo R. M. de Oliveira, J. Tércio B. Ferreira
Publikováno v: Tetrahedron Letters. 33:49-52
Conjugate additions of lower order and higher order cyano cuprates containing the cis -2-tri- n -butylstannylvinyl group to cycloalkenones have been studied. The higher order cuprates were more reactive towards hindered enones such as 4,4- dimethylcy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1500100388fe351888fc450c81a63c4b
https://doi.org/10.1016/s0040-4039(00)77670-2
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10
New Strategies for Intramolecular Annulations: Intramolecular Additions of Silyloxycyclopropane-Derived Anions; Application to Hydrindenone Syntheses
Autor: Fabio Simonelli, Joseph P. Marino, Peter J. Stengel, J. Tércio B. Ferreira
Publikováno v: Journal of the Brazilian Chemical Society v.9 n.4 1998
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 9, Issue: 4, Pages: 345-356, Published: AUG 1998
Journal of the Brazilian Chemical Society, Vol 9, Iss 4, Pp 345-356 (1998)
As an extension to our work on intramolecular annulations via silyloxycyclopropane derived anions, we have investigated the chemistry of cyclopentyl cyclopropane systems, 6-9, in an effort to prepare stereospecifically functionalized hydrindenones. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a6aadd7743349533a337754b8f71198
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50531998000400007
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