Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Peter J. Steinbach"'
Autor:
Andrea Mussini, Pietro Delcanale, Melissa Berni, Stefano Pongolini, Mireia Jordà-Redondo, Montserrat Agut, Peter J. Steinbach, Santi Nonell, Stefania Abbruzzetti, Cristiano Viappiani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5751 (2024)
Modular supramolecular complexes, where different proteins are assembled to gather targeting capability and photofunctional properties within the same structures, are of special interest for bacterial photodynamic inactivation, given their inherent b
Externí odkaz:
https://doaj.org/article/a3e9fb8854e242eebae7e744c3afca4d
Autor:
F. Graeme Frost, Marie Morimoto, Prashant Sharma, Lyse Ruaud, Newell Belnap, Daniel G. Calame, Yuri Uchiyama, Naomichi Matsumoto, Machteld M. Oud, Elise A. Ferreira, Vinodh Narayanan, Sampath Rangasamy, Matt Huentelman, Lisa T. Emrick, Ikuko Sato-Shirai, Satoko Kumada, Nicole I. Wolf, Peter J. Steinbach, Yan Huang, Barbara N. Pusey, Sandrine Passemard, Jonathan Levy, Séverine Drunat, Marie Vincent, Agnès Guet, Emanuele Agolini, Antonio Novelli, Maria Cristina Digilio, Jill A. Rosenfeld, Jennifer L. Murphy, James R. Lupski, Gilbert Vezina, Ellen F. Macnamara, David R. Adams, Maria T. Acosta, Cynthia J. Tifft, William A. Gahl, May Christine V. Malicdan
Publikováno v:
Undiagnosed Diseases Network 2023, ' Bi-allelic SNAPC4 variants dysregulate global alternative splicing and lead to neuroregression and progressive spastic paraparesis ', American journal of human genetics, vol. 110, no. 4, pp. 663-680 . https://doi.org/10.1016/j.ajhg.2023.03.001
American Journal of Human Genetics, 110, 4, pp. 663-680
American Journal of Human Genetics, 110, 663-680
American Journal of Human Genetics, 110, 4, pp. 663-680
American Journal of Human Genetics, 110, 663-680
Item does not contain fulltext The vast majority of human genes encode multiple isoforms through alternative splicing, and the temporal and spatial regulation of those isoforms is critical for organismal development and function. The spliceosome, whi
Autor:
Spyros, Batzios, Galit, Tal, Andrew T, DiStasio, Yanyan, Peng, Christiana, Charalambous, Paola, Nicolaides, Erik-Jan, Kamsteeg, Stanley H, Korman, Hanna, Mandel, Peter J, Steinbach, Ling, Yi, Summer R, Fair, Mark E, Hester, Anthi, Drousiotou, Stephen G, Kaler
Publikováno v:
Human Molecular Genetics. 31:4121-4130
The high-affinity copper transporter CTR1 is encoded by CTR1 (SLC31A1), a gene locus for which no detailed genotype–phenotype correlations have previously been reported. We describe identical twin male infants homozygous for a novel missense varian
Autor:
Sergio A. Hassan, Peter J. Steinbach
Publikováno v:
Journal of Biological Physics. 48:151-166
Computational design of antimicrobial peptides (AMPs) is a promising area of research for developing novel agents against drug-resistant bacteria. AMPs are present naturally in many organisms, from bacteria to humans, a time-tested mechanism that mak
Autor:
Prashant Sharma, Marie Reichert, Yan Lu, Thomas C Markello, David R Adams, Peter J Steinbach, Brie K Fuqua, Xenia Parisi, Stephen G Kaler, Christopher D Vulpe, Gregory J Anderson, William A Gahl, May Christine V Malicdan
Publikováno v:
PLoS Genetics, Vol 15, Iss 5, p e1008143 (2019)
Maintenance of the correct redox status of iron is functionally important for critical biological processes. Multicopper ferroxidases play an important role in oxidizing ferrous iron, released from the cells, into ferric iron, which is subsequently d
Externí odkaz:
https://doaj.org/article/8434e917264b45e197052e868151132b
Autor:
Reem Kais Jan, Daniel L. Kastner, Francesco Boin, Chris T. Derk, Kathleen D. Kolstad, Vivien Hsu, Heather Gladue, Virginia D. Steen, Avram Goldberg, Paula S. Ramos, Victoria K. Shanmugam, Dinesh Khanna, Lorinda Chung, Ayo P. Doumatey, Richard M. Silver, Elana J. Bernstein, Amy R. Bentley, Pravitt Gourh, Nadia D. Morgan, Ami A. Shah, Maureen D. Mayes, Lesley Ann Saketkoo, Fredrick M. Wigley, Steven E. Boyden, Brynn Kron, Elena Schiopu, Benjamin D. Korman, Lindsey A. Criswell, Peter J. Steinbach, S. Louis Bridges, Suzanne Kafaja, Thomas A. Medsger, Daniel Shriner, James C. Mullikin, Settara C. Chandrasekharappa, Jessica K. Gordon, Robyn T. Domsic, Elaine F. Remmers, John Varga, Adebowale Adeyemo, Sarah A. Safran, Theresa Alexander, Marcin Trojanowski, Charles N. Rotimi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 1
Significance HLA alleles have previously been implicated with scleroderma risk, but, in this study, using a European American ancestral cohort and a newly recruited large cohort of African Americans, we comprehensively define the HLA alleles and amin
Autor:
Anjum Ansari, Viktoriya Zvoda, Mitchell Connolly, Aline Arra, Peter J. Steinbach, Phoebe A. Rice
Publikováno v:
J Phys Chem B
Gene regulation depends on proteins that bind to specific DNA sites. Such specific recognition often involves severe DNA deformations, including sharp kinks. It has been unclear how rigid or flexible these protein-induced kinks are. Here, we investig
Autor:
Peter J. Steinbach
Publikováno v:
The Journal of Physical Chemistry B. 122:11355-11362
A continuum solvent model based on screened Coulomb potentials has been simplified and parameterized to sample native-like structures in replica-exchange simulations of each of six different peptides and mini-proteins. Low-energy, native and non-nati
Autor:
A. Carl Whittington, Shawn M. Sternisha, Gianluigi Veglia, Malcolm M. McCray, Juliana A. Martinez Fiesco, Brian G. Miller, Carol M. Porter, Timothy M. Logan, Peter J. Steinbach, Cristina Olivieri
Publikováno v:
Biophys J
Human glucokinase (GCK) is the prototypic example of an emerging class of proteins with allosteric-like behavior that originates from intrinsic polypeptide dynamics. High-resolution NMR investigations of GCK have elucidated millisecond-timescale dyna
Autor:
Suse Broyde, Hong Mu, Sagnik Chakraborty, Debamita Paul, Jung Hyun Min, Peter J. Steinbach, Anjum Ansari
Publikováno v:
Nucleic Acids Research
Rad4/XPC recognizes diverse DNA lesions including ultraviolet-photolesions and carcinogen-DNA adducts, initiating nucleotide excision repair. Studies have suggested that Rad4/XPC senses lesion-induced helix-destabilization to flip out nucleotides fro