Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Peter J. Slavish"'
Autor:
Peter J. Slavish, Maxime G. Cuypers, Mary Ashley Rimmer, Alireza Abdolvahabi, Trushar Jeevan, Gyanendra Kumar, Jamie A. Jarusiewicz, Sivaraja Vaithiyalingam, Jeremy C. Jones, John J. Bowling, Jeanine E. Price, Rebecca M. DuBois, Jaeki Min, Richard J. Webby, Zoran Rankovic, Stephen W. White
Publikováno v:
European journal of medicinal chemistry. 247
Influenza is one of the leading causes of disease-related mortalities worldwide. Several strategies have been implemented during the past decades to hinder the replication cycle of influenza viruses, all of which have resulted in the emergence of res
Publikováno v:
Journal of Molecular Graphics and Modelling. 81:197-210
The Bromodomain and Extra-Terminal domain family (BET) family of proteins are involved in the regulation of gene transcription, and their dysregulation is implicated in several diseases including cancer. BET proteins contain two tandem bromodomains (
Autor:
Philip M. Potter, Sergio C. Chai, Brett Waddell, Marie Morfouace, Anang A. Shelat, Nagakumar Bharatham, R. Kiplin Guy, William R. Shadrick, Brandon Young, Peter J. Slavish, Richard E. Lee, Jonathan Low, Stefan Knapp, Cynthia Tallant, Vincent A. Boyd, Michele Connelly, Taosheng Chen, Martine F. Roussel
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:25-36
Within the last decade, the Bromodomain and Extra-Terminal domain family (BET) of proteins have emerged as promising drug targets in diverse clinical indications including oncology, auto-immune disease, heart failure, and male contraception. The BET
Autor:
Brandon Young, Karina J. Yoon, Peter J. Slavish, Aubrey L. Miller, Anang A. Shelat, Philip M. Potter
Publikováno v:
Cancer Research. 78:5794-5794
Pancreatic ductal adenocarcinoma (PDAC), the most common type of pancreatic cancer, is a highly aggressive tumor with a 5-year survival of We and others document that inhibiting the function of BET bromodomain proteins suppresses PDAC tumor growth in