Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Peter J. Skene"'
Autor:
Samir Rachid Zaim, Mark-Phillip Pebworth, Imran McGrath, Lauren Okada, Morgan Weiss, Julian Reading, Julie L. Czartoski, Troy R. Torgerson, M. Juliana McElrath, Thomas F. Bumol, Peter J. Skene, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) is being increasingly used to study gene regulation. However, major analytical gaps limit its utility in studying gene regulatory programs in complex diseas
Externí odkaz:
https://doaj.org/article/510a659dc6a34101b8936defcaa98168
Autor:
Aarthi Talla, Suhas V. Vasaikar, Gregory Lee Szeto, Maria P. Lemos, Julie L. Czartoski, Hugh MacMillan, Zoe Moodie, Kristen W. Cohen, Lamar B. Fleming, Zachary Thomson, Lauren Okada, Lynne A. Becker, Ernest M. Coffey, Stephen C. De Rosa, Evan W. Newell, Peter J. Skene, Xiaojun Li, Thomas F. Bumol, M. Juliana McElrath, Troy R. Torgerson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long COVID or post-acute sequelae of SARS-CoV-2 (PASC) is a clinical syndrome featuring diverse symptoms that can persist for months following acute SARS-CoV-2 infection. The aetiologies may include persistent inflammation, unresolved tissue
Externí odkaz:
https://doaj.org/article/0a4ada69f9a3464f8bb10065779fdcc5
Autor:
Suhas V. Vasaikar, Adam K. Savage, Qiuyu Gong, Elliott Swanson, Aarthi Talla, Cara Lord, Alexander T. Heubeck, Julian Reading, Lucas T. Graybuck, Paul Meijer, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Xiao-jun Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
The analysis of longitudinal bulk and single-cell multi-omics data is a highly complex task. Here, the authors introduce PALMO, a software platform with five modules to analyse longitudinal bulk and single-cell multi-omics data, which is extensively
Externí odkaz:
https://doaj.org/article/9167378588ad444cbf7f985a5e41ce2a
Publikováno v:
BMC Bioinformatics, Vol 23, Iss 1, Pp 1-14 (2022)
Abstract Background Barcode-based multiplexing methods can be used to increase throughput and reduce batch effects in large single-cell genomics studies. Despite advantages in flexibility of sample collection and scale, there are additional complicat
Externí odkaz:
https://doaj.org/article/21179aa92949406b80b4c94dfe7b6c4c
Autor:
Palak C. Genge, Charles R. Roll, Alexander T. Heubeck, Elliott Swanson, Nina Kondza, Cara Lord, Morgan Weiss, Veronica Hernandez, Cole Phalen, Zachary Thomson, Troy R. Torgerson, Peter J. Skene, Thomas F. Bumol, Julian Reading
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100900- (2021)
Summary: Deep immune profiling is essential for understanding the human immune system in health and disease. Successful biological interpretation of this data requires consistent laboratory processing with minimal batch-to-batch variation. Here, we d
Externí odkaz:
https://doaj.org/article/fae212fe174d4a2a85ae33c7cb9322d0
Autor:
Adam K. Savage, Miriam V. Gutschow, Tony Chiang, Kathy Henderson, Richard Green, Monica Chaudhari, Elliott Swanson, Alexander T. Heubeck, Nina Kondza, Kelli C. Burley, Palak C. Genge, Cara Lord, Tanja Smith, Zachary Thomson, Aldan Beaubien, Ed Johnson, Jeff Goldy, Hamid Bolouri, Jane H. Buckner, Paul Meijer, Ernest M. Coffey, Peter J. Skene, Troy R. Torgerson, Xiao-jun Li, Thomas F. Bumol
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102404- (2021)
Summary: Multi-omic profiling of human peripheral blood is increasingly utilized to identify biomarkers and pathophysiologic mechanisms of disease. The importance of these platforms in clinical and translational studies led us to investigate the impa
Externí odkaz:
https://doaj.org/article/a1e55c9d0af740fea6a687681949f26b
Autor:
Rebecca Resnick, Chao-Jen Wong, Danielle C. Hamm, Sean R. Bennett, Peter J. Skene, Sandra B. Hake, Steven Henikoff, Silvère M. van der Maarel, Stephen J. Tapscott
Publikováno v:
Cell Reports, Vol 29, Iss 7, Pp 1812-1820.e5 (2019)
Summary: The DUX4 transcription factor is briefly expressed in the early cleavage-stage embryo, where it induces an early wave of zygotic gene transcription, whereas its mis-expression in skeletal muscle causes the muscular dystrophy facioscapulohume
Externí odkaz:
https://doaj.org/article/4cc4badd9d2747f5ab74fb6f1b54c280
Autor:
Elliott Swanson, Cara Lord, Julian Reading, Alexander T Heubeck, Palak C Genge, Zachary Thomson, Morgan DA Weiss, Xiao-jun Li, Adam K Savage, Richard R Green, Troy R Torgerson, Thomas F Bumol, Lucas T Graybuck, Peter J Skene
Publikováno v:
eLife, Vol 10 (2021)
Single-cell measurements of cellular characteristics have been instrumental in understanding the heterogeneous pathways that drive differentiation, cellular responses to signals, and human disease. Recent advances have allowed paired capture of prote
Externí odkaz:
https://doaj.org/article/046189b6ef98402f806f13d5a7619de7
Autor:
Claire E. Gustafson, Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Mark-Phillip Pebworth, Lauren Y. Okada, Alexander T. Heubeck, Charles R. Roll, Veronica Hernandez, Morgan Weiss, Palak C. Genge, Julian Reading, Josephine R. Giles, Sasikanth Manne, Jeanette Dougherty, CJ Jasen, Allison R. Greenplate, Lynne A. Becker, Lucas T. Graybuck, Suhas V. Vasaikar, Gregory L. Szeto, Adam K. Savage, Cate Speake, Jane H. Buckner, Xiao-jun Li, Troy R. Torgerson, E. John Wherry, Thomas F. Bumol, Laura A. Vella, Sarah E. Henrickson, Peter J. Skene
The naive T cell compartment undergoes multiple changes across age that associate with altered susceptibility to infection and autoimmunity. In addition to the acquisition of naive-like memory T cell subsets, mouse studies describe substantial molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::510ab66e66b266ad28cf5b58559c3b29
https://doi.org/10.1101/2022.10.04.510869
https://doi.org/10.1101/2022.10.04.510869
Autor:
Peter J Skene, Steven Henikoff
Publikováno v:
eLife, Vol 6 (2017)
We describe Cleavage Under Targets and Release Using Nuclease (CUT&RUN), a chromatin profiling strategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific protein-DNA complexes into the supernatant for paired-end
Externí odkaz:
https://doaj.org/article/bb7be78a927f456284491ff163b499a7