Výsledky vyhledávání - "Peter J. Sausen"

Characterization of the MethionineS-Oxidase Activity of Rat Liver and Kidney Microsomes: Immunochemical and Kinetic Evidence for FMO3 Being the Major Catalyst

Autor: Adnan A. Elfarra, Sharon L. Ripp, Renee J. Krause, Richard M. Philpot, Peter J. Sausen, Lila H. Overby

Publikováno v: Archives of Biochemistry and Biophysics. 333:109-116

Methionine is oxidized to methionine sulfoxide by rat liver and kidney microsomes in an O2- and NADPH-dependent manner. In all microsomal assays, no methionine sulfone was detected. Use of a monoclonal antibody to rat liver cytochrome P-450 reductase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fb309b67b460e472ba379a9aa76682
https://doi.org/10.1006/abbi.1996.0370

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Elevated 8-hydroxydeoxyguanosine in hepatic DNA of rats following exposure to peroxisome proliferators: relationship to mitochondrial alterations

Autor: Michelle L. Rose, Douglas C. Lee, Russell C. Cattley, Peter J. Sausen

Publikováno v: Carcinogenesis. 16:1795-1801

Recent studies have indicated a lack of correlation between hepatic 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels and the carcinogenicity of peroxisome proliferators (PP) and suggested that DNA in intact hepatic nuclei may be insensitive to increases i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb0502c838cede59e3e29754d6098a
https://doi.org/10.1093/carcin/16.8.1795

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What It Means to Be Global

Autor: Jin Ren, Robert S. Wallis, Jan Willem van der Laan, Peter J. Sausen, William Slikker, Ruth Roberts

Publikováno v: Toxicological Sciences. 127:313-314

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e588b172a1d4aee829bef5372f9fb5
https://doi.org/10.1093/toxsci/kfs079

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Paradoxical increase in peroxisomal cyanide-insensitive respiration following dietary exposure to WY-14,643 in the perfused liver

Autor: Ronald G. Thurman, Barbara J. Keller, Russell C. Cattley, Peter J. Sausen, Heidi K. Bojes

Publikováno v: Toxicology and applied pharmacology. 137(2)

WY-14,643, a lipid-lowering drug, increases basal rates of oxygen uptake in perfused livers. Because peroxisomes consume oxygen for H2O2 production and are induced by WY-14,643 treatment, it is possible that peroxisomal beta-oxidation can account for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2846832dfa92469272a53ac85efb72e
https://pubmed.ncbi.nlm.nih.gov/8661345

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Gemfibrozil-induced peroxisome proliferation and hepatomegaly in male F344 rats

Autor: Richard T. Miller, Vonda J. Teets, Peter J. Sausen, Russell C. Cattley, Karin S. Voss

Publikováno v: Cancer letters. 97(2)

Gemfibrozil is a widely used hypolipidemic drug in humans that causes peroxisome proliferation and hepatocarcinogenesis in rodents. The induction of hepatomegaly and hepatic peroxisome proliferation (measured as peroxisomal acyl CoA oxidase activity)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cb73c2f3817610d3dc81e414dd9fff8
https://pubmed.ncbi.nlm.nih.gov/7497472

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Reactivity of cysteine S-conjugate sulfoxides: formation of S-[1-chloro-2-(S-glutathionyl)vinyl]-L-cysteine sulfoxide by the reaction of S-(1,2-dichlorovinyl)-L-cysteine sulfoxide with glutathione

Autor: Adnan A. Elfarra, Peter J. Sausen

Publikováno v: Chemical research in toxicology. 4(6)

S-(1,2-Dichlorovinyl)-L-cysteine (DCVC) sulfoxide, a putative metabolite of the toxic cysteine S-conjugate DCVC, was synthesized by the reaction of DCVC with H2O2 and characterized by fast atom bombardment mass spectrometry (FAB-MS) and proton nuclea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e977cb779eab5b279b0751b15a8d5b75
https://pubmed.ncbi.nlm.nih.gov/1807449

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