Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Peter J. Roughley"'
Autor:
Fackson Mwale, Koichi Masuda, Michael P. Grant, Laura M. Epure, Kenji Kato, Shingo Miyazaki, Kevin Cheng, Junichi Yamada, Won C. Bae, Carol Muehleman, Peter J. Roughley, John Antoniou
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background The degeneration of the intervertebral disc (IVD) is characterized by proteolytic degradation of the extracellular matrix, and its repair requires the production of an extracellular matrix with a high proteoglycan-to-collagen rati
Externí odkaz:
https://doaj.org/article/6d81dda5de7c463a91c820eac21bf4fe
Autor:
Benjamin A Walter, Morakot Likhitpanichkul, Svenja Illien-Junger, Peter J Roughley, Andrew C Hecht, James C Iatridis
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118358 (2015)
Intervertebral disc (IVD) degeneration is an important contributor to the development of back pain, and a key factor relating pain and degeneration are the presence of pro-inflammatory cytokines and IVD motion. There is surprisingly limited understan
Externí odkaz:
https://doaj.org/article/e84fc30f9a2f4ccbad50e894c1f7e35b
Autor:
H Richard, J Sampalis, Laura M. Epure, Michael P. Grant, J Antoniou, Fackson Mwale, Sheila Laverty, Peter J. Roughley
Publikováno v:
European Cells & Materials, Vol 37, Pp 347-359 (2019)
Osteoarthritis (OA) is a degenerative joint disease characterised by a progressive degradation of articular cartilage and underlaying bone and is associated with pain and disability. Currently, there is no medical treatment to reverse or even retard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95da497d44371d9d51e6c52f9bed7325
https://doi.org/10.22203/ecm.v037a21
https://doi.org/10.22203/ecm.v037a21
Autor:
Peter J Roughley, John S Mort
Publikováno v:
Journal of Experimental Orthopaedics, Vol 1, Iss 1, Pp n/a-n/a (2014)
Abstract Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads. It is present in the extracellular matrix in the form of proteog
Externí odkaz:
https://doaj.org/article/4074f6aa7b024f39a85be7a2e4f491ee
Autor:
Marc D. McKee, Pierre Moffatt, Peter J. Roughley, Francis H. Glorieux, Frank Rauch, Telma Palomo, Hadil Al-Jallad
Publikováno v:
Bone. 76:115-120
Osteogenesis imperfecta type VI is caused by mutations in SERPINF1, which codes for pigment-epithelium derived factor (PEDF). Most of the reported SERPINF1 mutations lead to premature termination codons, but three in-frame insertion or deletion mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d207e4e029fc3d84dbe6f42cf1d1a2a4
https://doi.org/10.1016/j.bone.2015.04.008
https://doi.org/10.1016/j.bone.2015.04.008
Autor:
James C. Iatridis, Devina Purmessur, Robert J. Linhardt, Marisa C. Cornejo, Samuel K. Cho, Andrew C. Hecht, Peter J. Roughley
Publikováno v:
The Spine Journal. 15:1060-1069
Painful human intervertebral discs (IVDs) exhibit nerve growth deep into the IVD. Current treatments for discogenic back pain do not address the underlying mechanisms propagating pain and are often highly invasive or only offer temporary symptom reli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a435308c2f244b0cca587ae2513937
https://doi.org/10.1016/j.spinee.2015.02.003
https://doi.org/10.1016/j.spinee.2015.02.003
Autor:
Wayne K Marshall, Rajiv Gandhi, Bahareh Saffar, Johanne Martel-Pelletier, Hassan Fahmi, Bertrand Lussier, Peter J. Roughley, Jean-Pierre Pelletier, Ying-Hua Li, David Lagares, Meryem Blati, Nizar N. Mahomed, Mohit Kapoor, Y. Raja Rampersaud, Yue Zhang, Faezeh Vasheghani, Daniel Lajeunesse, Helal Endisha
Publikováno v:
Annals of the Rheumatic Diseases. 74:569-578
Objectives We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created inducible cartilage-specific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be4d025365d2b3678eab2e6a7361b161
https://doi.org/10.1136/annrheumdis-2014-205743
https://doi.org/10.1136/annrheumdis-2014-205743
Autor:
James D. Kang, Pedro Pohl, Nam Vo, Steven S. Shapiro, Gwendolyn Sowa, Laura J. Niedernhofer, Joon S. Lee, Paul D. Robbins, Kevin Ngo, Dong Wang, Peter J. Roughley, Peter Di, Adriana S. Leme
Publikováno v:
Spine. 42(20)
ADAMTS5-deficient and wild type (WT) mice were chronically exposed to tobacco smoke to investigate effects on intervertebral disc degeneration (IDD).The aim of this study was to demonstrate a role for ADAMTS5 in mediating tobacco smoking-induced IDD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28232f03f0545851a09885cdd0f57f77
https://pubmed.ncbi.nlm.nih.gov/28570296
https://pubmed.ncbi.nlm.nih.gov/28570296
Publikováno v:
Journal of Negative Results in Biomedicine
Background In vitro studies suggest that the multiple functions of decorin are related to both its core protein and its dermatan sulfate chain. To determine the contribution of the dermatan sulfate chain to the functional properties of decorin in viv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31d47765111fc808bfb75b8c4a6350c0
https://doi.org/10.1186/s12952-017-0074-3
https://doi.org/10.1186/s12952-017-0074-3
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1840:3181-3189
Background Aggrecan is the major non-collagenous component of the intervertebral disc. It is a large proteoglycan possessing numerous glycosaminoglycan chains and the ability to form aggregates in association with hyaluronan. Its abundance and unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba6b07990237fdfb25882fdb9b9befb
https://doi.org/10.1016/j.bbagen.2014.07.013
https://doi.org/10.1016/j.bbagen.2014.07.013