Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Peter J. Prince"'
1
Clinical pharmacology of AMG 181, a gut-specific human anti-α4β7monoclonal antibody, for treating inflammatory bowel diseases
Autor: Anthony M. Treacy, Virginia M Platt, Christine M. Evangelista, Dominic C. Borie, Lynn Smith, Mark Yen, Jane M. Andrews, Peter J. Prince, Kefei Zhou, Wei-Jian Pan, Christine D Krill, Graham L. Radford-Smith, Jason M. Gow, Kaz O Reynhardt, Jonathan Lee, Zhigang Yu, David R. Doherty, Kathleen Köck, William A. Rees, Barbara A. Sullivan, Sonal K. Patel, Jing Jing Shen
Publikováno v: British Journal of Clinical Pharmacology. 78:1315-1333
AIMS AMG 181 pharmacokinetics/pharmacodynamics (PK/PD), safety, tolerability and effects after single subcutaneous (s.c.) or intravenous (i.v.) administration were evaluated in a randomized, double-blind, placebo-controlled study. METHODS Healthy mal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b4affc6406b420c1a3ccb1e05e144e99
https://doi.org/10.1111/bcp.12418
Zobrazit plný text záznamu
2
Pharmacology of AMG 181, a human anti-α4β7antibody that specifically alters trafficking of gut-homing T cells
Autor: Peter J. Prince, Wei-Jian Pan, Larry C. Wienkers, XZ Xia, CM Sheckler, Hailing Hsu, C D Krill, Dominique C. Borie, AA Anderson, Ian Foltz, Palaniswami Rathanaswami, SP Lear, William A. Rees, Sonal K. Patel, F Lee, Kathy Manchulenko, BJ Harder, Doherty, JL Brandvig, JL Lynch, Brian Mingtung Chan, M Zhang, John A. Wisler, Kaz O Reynhardt
Publikováno v: British Journal of Pharmacology. 169:51-68
Background and Purpose AMG 181 is a human anti-α4β7 antibody currently in phase 1 and 2 trials in subjects with inflammatory bowel diseases. AMG 181 specifically targets the α4β7 integrin heterodimer, blocking its interaction with mucosal address
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c278748ec53018255ae698adfb9c3f0e
https://doi.org/10.1111/bph.12134
Zobrazit plný text záznamu
3
Prediction of clinical pharmacokinetics of AMG 181, a human anti-α4β7 monoclonal antibody for treating inflammatory bowel diseases
Autor: John A. Wisler, Peter J. Prince, Kathleen Köck, Hailing Hsu, Kai O. Reynhardt, Wei-Jian Pan, Dominic C. Borie, William A. Rees, Zhigang Yu, Hong Li, David H. Salinger
Publikováno v: Pharmacology Research & Perspectives
The purpose of this study was to predict a safe starting dose of AMG 181, a human anti-α 4 β 7 antibody for treating inflammatory bowel diseases, based on cynomolgus monkey pharmacokinetic (PK) and pharmacodynamic (PD) data. A two-compartment model
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7681a5910c5d5de36930954856ae429d
http://europepmc.org/articles/PMC4317229
Zobrazit plný text záznamu
4
Measurement of in vivo therapeutic mAb concentrations: comparison of conventional serum/plasma collection and analysis to dried blood spot sampling
Autor: Peter J. Prince, Marcus Soto, Katherine C Matsuda, Colin Hall, Cassandra Baker-Lee, George Scott, Marc W. Retter
Publikováno v: Bioanalysis. 5(16)
Background: Development of an alternative sampling method that uses small amounts of whole blood, such as dried blood spots (DBS), would be an advance in the quantitative assay field. Previously, we assessed the ability to quantitate therapeutic mono
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6f61cf2868b1d8b6037f08f49a272a
https://pubmed.ncbi.nlm.nih.gov/23937133
Zobrazit plný text záznamu
5
Off-target platelet activation in macaques unique to a therapeutic monoclonal antibody
Autor: Dan A. Rock, Wei-Jian Pan, Michael J. Santostefano, Hugo M. Vargas, James F. Reindel, Duc Tran, Madeline M. Fort, Kai O. Reynhardt, Jacqueline A. Kirchner, Padma K. Narayanan, Remi Jawando, William A. Rees, Nancy E. Everds, Peter J. Prince, Sean Lear, Kelly Hensley, Christine Vissinga
Publikováno v: Toxicologic pathology. 40(6)
AMG X, a human neutralizing monoclonal antibody (mAb) against a soluble human protein, caused thrombocytopenia, platelet activation, reduced mean arterial pressure, and transient loss of consciousness in cynomolgus monkeys after first intravenous adm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b455e0b072e4e10b74933b0f1af8bc
https://pubmed.ncbi.nlm.nih.gov/22552394
Zobrazit plný text záznamu
6
Assessment of DBS technology for the detection of therapeutic antibodies
Autor: Katherine C Matsuda, G Scott, Peter J. Prince, Marc W. Retter
Publikováno v: Bioanalysis. 2(8)
Background: Quantitating levels of therapeutic proteins in serum or plasma is critical for determining exposure levels and establishing pharmacokinetic parameters. Traditionally, whole blood is not used, mostly due to its inability to be frozen and p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b97b8af1bd07d966cc5b59a43f3ab62
https://pubmed.ncbi.nlm.nih.gov/21083345
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje