Výsledky vyhledávání - "Peter J. Perrino"

Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users

Autor: Salvatore V. Colucci, Cynthia Bartlett, Ira Smith, Edward M. Sellers, Peter J. Perrino, Stephen C. Harris, Megan J. Shram

Publikováno v: Journal of Clinical Pharmacology

The objective of this study was to evaluate abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered, crushed reformulated OxyContin® (oxycodone HCl controlled-release) tablets (ORF), relative to crushed original

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88273a9852434c79618ae233ba74b67
http://europepmc.org/articles/PMC4263153

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Pharmacokinetics, Tolerability, and Safety of Intranasal Administration of Reformulated OxyContin® Tablets Compared with Original OxyContin® Tablets in Healthy Adults

Autor: Stephen C. Harris, Salvatore V. Colucci, Glen Apseloff, Peter J. Perrino

Publikováno v: Clinical Drug Investigation

Background and Objective Reformulated OxyContin® (oxycodone-HCl controlled release) tablets (ORF) became available in the United States in August 2010. The original formulation of OxyContin® (oxycodone-HCl controlled release) tablets (OC) used a de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32d3920c494267a67c859bcc18819887
http://europepmc.org/articles/PMC3664752

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Effect of Ketoconazole on the Pharmacokinetic Profile of Buprenorphine following Administration of a Once-Weekly Buprenorphine Transdermal System

Autor: Peter J. Perrino, Sarah A. O’Keefe, Salvatore V. Colucci, Stephen C. Harris, Alessandra Cipriano, Ram P. Kapil, Gregory Michels, Robert J. Noveck, Manjunath S. Shet

Publikováno v: Clinical Drug Investigation. 32:583-592

Background and Objective: Buprenorphine is extensively metabolized by cytochrome P450 (CYP) 3A4. This study evaluated the effect of ketoconazole, a CYP3A4 inhibitor, on the metabolism of buprenorphine following the administration of a buprenorphine t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2427dc266e74222a773952de29aaafce
https://doi.org/10.2165/11633060-000000000-00000

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Attractiveness of reformulated OxyContin(R) tablets: assessing comparative preferences and tampering potential

Autor: Salvatore V. Colucci, Stephen C. Harris, Peter J. Perrino, Edward M. Sellers

Publikováno v: Journal of psychopharmacology (Oxford, England). 27(9)

Reformulated OxyContin® (oxycodone HCl controlled-release or ORF) was developed as a tamper and abuse-deterrent product, to reduce the risk of product abuse, misuse and their consequences. This noninterventional single-session study asked participan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc899b27d091f04428cf1620d6be2425
https://pubmed.ncbi.nlm.nih.gov/23784739

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[Untitled]

Autor: Gregory M. Kochak, Deborah Kachmar, Frank Honc, Peter J. Perrino, Hanspeter Egger, Robert Iannucci, Sudhakar Pai

Publikováno v: Pharmaceutical Research. 10:49-55

Prinomide tromethamine, a nonsteroidal antiinflammatory drug, was orally administered at doses of 250, 500, and 1000 mg every 12 hr for 28 days to healthy male volunteers. The pharmacokinetic behavior of prinomide and its primary plasma metabolite di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3571a20bee21a500ad1fcf13a98b433b
https://doi.org/10.1023/a:1018916811904

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High-performance liquid chromatographic assay for two rifamycin-derived hypocholesterolemic agents in liver and biological fluids

Autor: Peter J. Perrino, David J. Moore, Christine P. Klerer, Philmore Robertson

Publikováno v: Journal of chromatography. 612(2)

CGP 43371 (compound I), a mono-pivaloyl oxazole derivative of a 3-piperazino-rifamycin, has been in clinical trials as a potential hypocholesterolemic agent. A reversed-phase high-performance liquid chromatographic (HPLC) assay was developed using a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de996a438ae62fea26869379ae0b84c
https://pubmed.ncbi.nlm.nih.gov/8468390

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Abuse Potential of Intravenous Oxycodone/Naloxone Solution in Nondependent Recreational Drug Users

Autor: Stephen C. Harris, Peter J. Perrino, Megan J. Shram, Yi Wang, Cynthia Bartlett, Salvatore V. Colucci

Publikováno v: Clinical Drug Investigation

Background and Objective Abuse of opioid analgesics has become a public health issue. Some opioid abusers use intravenous administration to increase the magnitude of positive reinforcing effects. Intravenous co-administration of oxycodone with naloxo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bffdd1252729f8f7ae1e815a09f8448

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