Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Peter J. Noy"'
Autor:
Elizabeth J. Haining, Alexandra L. Matthews, Peter J. Noy, Hanna M. Romanska, Helen J. Harris, Jeremy Pike, Martina Morowski, Rebecca L. Gavin, Jing Yang, Pierre-Emmanuel Milhiet, Fedor Berditchevski, Bernhard Nieswandt, Natalie S. Poulter, Steve P. Watson, Michael G. Tomlinson
Publikováno v:
Platelets, Vol 28, Iss 7, Pp 629-642 (2017)
The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact. We have previously shown that tetraspanin Tspan9 is expressed
Externí odkaz:
https://doaj.org/article/450db8670693458ca5e511caed983da9
Publikováno v:
Platelets, Vol 28, Iss 4, Pp 333-341 (2017)
A disintegrin and metalloprotease (ADAM) 10 and ADAM17 are ubiquitous transmembrane “molecular scissors” which proteolytically cleave, or shed, the extracellular regions of other transmembrane proteins. ADAM10 is essential for development because
Externí odkaz:
https://doaj.org/article/0c706eef3dbe4aa2963e1548b70a8e04
Autor:
Peter J. Noy, Rebecca L. Gavin, Dario Colombo, Elizabeth J. Haining, Jasmeet S. Reyat, Holly Payne, Ina Thielmann, Adam B. Lokman, Georgiana Neag, Jing Yang, Tammy Lloyd, Neale Harrison, Victoria L. Heath, Chris Gardiner, Katharine M. Whitworth, Joseph Robinson, Chek Z. Koo, Alessandro Di Maio, Paul Harrison, Steven P. Lee, Francesco Michelangeli, Neena Kalia, G. Ed Rainger, Bernhard Nieswandt, Alexander Brill, Steve P. Watson, Michael G. Tomlinson
Publikováno v:
Haematologica, Vol 104, Iss 9 (2019)
Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact
Externí odkaz:
https://doaj.org/article/72942b750efd4ee2a4e3fd070b4f38e4
Autor:
Katharine Whitworth, Paul Harrison, Georgiana Neag, Neale Harrison, Chek Ziu Koo, Michael G. Tomlinson, Alexander Brill, Rebecca L. Gavin, G. Ed Rainger, Adam B. Lokman, Elizabeth J. Haining, Dario Colombo, Jasmeet S. Reyat, Steve P. Watson, Steven P. Lee, Jing Yang, Francesco Michelangeli, Neena Kalia, Bernhard Nieswandt, Victoria L. Heath, Alessandro Di Maio, Holly Payne, Joseph Robinson, Peter J. Noy, Ina Thielmann, Chris Gardiner, Tammy Lloyd
Publikováno v:
Haematologica
Ca2+ entry via Orai1 store-operated Ca2+ channels in the plasma membrane is critical to cell function, and Orai1 loss causes severe immunodeficiency and developmental defects. The tetraspanins are a superfamily of transmembrane proteins that interact
Autor:
Edward T Davis, Michael G. Tomlinson, Lisa Seipold, Murat Keles, Natalie S. Poulter, Paul Saftig, Antonia Malinova, Stephan A. Mueller, Stefan F. Lichtenthaler, Alexandra L. Matthews, Bethany Cragoe, Hanh T.H. Nguyen, Stephen J. Briddon, Nicholas D. Holliday, Christos Pliotas, Chek Ziu Koo, Eric Rubinstein, Thomas A. McFarlane, Johanna Tüshaus, Michael C. Sykes, Justyna Szyroka, Eleanor Cull, Katie Willis, Haroon Ahmed, Alessandro Di Maio, Clara Apicella, Joelle Goulding, Peter J. Noy, Neale Harrison, Hung-En Hsia, Philip R. Morrison
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
The journal of biological chemistry 295(36), 12822-12839 (2020). doi:10.1074/jbc.RA120.012601
J Biol Chem
Journal of Biological Chemistry, 2020, 295 (36), pp.12822-12839. ⟨10.1074/jbc.ra120.012601⟩
Koo, C Z, Harrison, N, Noy, P J, Szyroka, J, Matthews, A L, Hsia, H-E, Müller, S A, Tüshaus, J, Goulding, J, Willis, K, Apicella, C, Cragoe, B, Davis, E, Keles, M, Malinova, A, McFarlane, T A, Morrison, P R, Nguyen, H T H, Sykes, M C, Ahmed, H, Maio, A D, Seipold, L, Saftig, P, Cull, E, Pliotas, C, Rubinstein, E, Poulter, N S, Briddon, S J, Holliday, N D, Lichtenthaler, S F & Tomlinson, M G 2020, ' The tetraspanin Tspan15 is an essential subunit of an ADAM10 scissor complex ', Journal of Biological Chemistry, vol. 295, no. 36, pp. 12822-12839 . https://doi.org/10.1074/jbc.RA120.012601
International audience; A disintegrin and metalloprotease 10 (ADAM10) is a transmembrane protein essential for embryonic development, and its dysregulation underlies disorders such as cancer, Alzheimer's disease, and inflammation. ADAM10 is a “mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8eb363ab27157e6e501561ef205a029
https://hal.sorbonne-universite.fr/hal-03124330
https://hal.sorbonne-universite.fr/hal-03124330
Autor:
Michael G. Tomlinson, Peter J. Noy, Martina Pigoni, Huanhuan Wang, Stefan F. Lichtenthaler, Armando Rossello, Carl P. Blobel, Tobias Brummer
Publikováno v:
The FASEB journal 32(7), 3560-3573 (2018). doi:10.1096/fj.201700823RR
The transmembrane protein, ADAM10 (a disintegrin and metalloprotease 10), has key physiologic functions-for example, during embryonic development and in the brain. During transit through the secretory pathway, immature ADAM10 (proADAM10) is converted
Autor:
Wenchun Chen, René P. Zahedi, Vladimir Chubanov, Anne-Laure Perraud, Attila Braun, Karen Wolf, Michael G. Tomlinson, Carsten Schmitz, Simon Stritt, Susanna Zierler, Thomas Gudermann, Bernhard Nieswandt, Isabelle C. Becker, Thomas Dandekar, Deviyani Rao, Heike M. Hermanns, Sanjeev K. Gotru, Masayuki Matsushita, Guido Stoll, Peter Kraft, Peter J. Noy
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:344-352
Objective— TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient receptor potential channel segment linked to a cytosolic α-type serine/threonine protein
Autor:
Myriam Chimen, Jasmeet S. Reyat, Justyna Szyroka, G. Ed Rainger, Peter J. Noy, Michael G. Tomlinson
Publikováno v:
The Journal of Immunology Author Choice
The recruitment of blood leukocytes across the endothelium to sites of tissue infection is central to inflammation, but also promotes chronic inflammatory diseases. A disintegrin and metalloproteinase 10 (ADAM10) is a ubiquitous transmembrane molecul
Autor:
Alexandra L. Matthews, Stefan F. Lichtenthaler, Edward T Davis, Hung-En Hsia, Antonia Malinova, Alessandro Di Maio, Michael G. Tomlinson, Justyna Szyroka, Paul Saftig, Michael C. Sykes, Neale Harrison, Katie Willis, Philip R. Morrison, Eleanor Cull, Chek Ziu Koo, Eric Rubinstein, Clara Apicella, Joelle Goulding, Stephen J. Briddon, Murat Keles, Lisa Seipold, Nicholas D. Holliday, Stephan A. Mueller, Bethany Cragoe, Natalie S. Poulter, Thomas A. McFarlane, Haroon Ahmed, Peter J. Noy, Johanna Tüshaus
A disintegrin and metalloprotease 10 (ADAM10) is essential for embryonic development and impacts on diseases such as cancer, Alzheimer’s and inflammatory diseases. ADAM10 is a ‘molecular scissor’ that proteolytically cleaves the extracellular r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6ba7b78aec233816b3516d596bd571
https://doi.org/10.1101/800557
https://doi.org/10.1101/800557
Autor:
Jing Yang, G. Ed Rainger, Alexandra L. Matthews, Jasmeet S. Reyat, Michael G. Tomlinson, David A. Rogers, Alice E. Charlton, Joanna Furmston, Peter J. Noy
Publikováno v:
The Journal of Biological Chemistry
A disintegrin and metalloprotease 10 (ADAM10) is a ubiquitously expressed transmembrane metalloprotease that cleaves the extracellular regions from its transmembrane substrates. ADAM10 is essential for embryonic development and is implicated in cance