Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Peter J. Neame"'
Autor:
Huntington Potter, Steven P. Bennett, Nicholas Governatori, Michelle Norden, Gary W. Arendash, Inge Wefes, Peter J. Neame, Takashi Mori, Juan Sanchez-Ramos, Jaya Padmanabhan, Melissa Runfeldt, Timothy Boyd
Publikováno v:
Journal of Alzheimer's Disease. 21:507-518
Rheumatoid arthritis (RA) is a negative risk factor for the development of Alzheimer's disease (AD). While it has been commonly assumed that RA patients' usage of non-steroidal anti-inflammatory drugs (NSAIDs) helped prevent onset and progression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca279fddeafcf0b369dbb82bf1c187b
https://doi.org/10.3233/jad-2010-091471
https://doi.org/10.3233/jad-2010-091471
Autor:
Jaya Padmanabhan, Timothy Boyd, Michelle Norden, Steven P. Bennett, Inge Wefes, Huntington Potter, Peter J. Neame
Publikováno v:
Journal of Neuroscience Methods. 184:320-326
A common problem faced by researchers using transgenic models to study disease is the phenotypic variability that exists within a group or colony of animals. Significant pathological analyses thus often require large numbers of mice to perform. Many
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f802d5f831fbffedb5372a1e4544ea1
https://doi.org/10.1016/j.jneumeth.2009.08.021
https://doi.org/10.1016/j.jneumeth.2009.08.021
Publikováno v:
Biochemical Journal. 361:231-241
Point mutations in the human fibroblast growth factor (FGF) receptor 3 gene (Fgfr3) produce a constitutively active receptor, which disrupts chondrocyte differentiation in the growth plate and results in skeletal dysplasias with severe shortening of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4f6b4ac3e051976466990d5eca358e
https://doi.org/10.1042/bj3610231
https://doi.org/10.1042/bj3610231
Autor:
Dick Heinegård, Anders Aspberg, Pilar Lorenzo, Michael T. Bayliss, Peter J. Neame, Patrik Önnerfjord
Publikováno v:
Journal of Biological Chemistry. 276:12201-12211
Asporin, a novel member of the leucine-rich repeat family of proteins, was partially purified from human articular cartilage and meniscus. Cloning of human and mouse asporin cDNAs revealed that the protein is closely related to decorin and biglycan.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d6842f6739563ceb540fc0947f954ea
https://doi.org/10.1074/jbc.m010932200
https://doi.org/10.1074/jbc.m010932200
Publikováno v:
Cellular and Molecular Life Sciences CMLS. 57:859-863
The leucine-rich proteoglycans (also known as "small, leucine-rich proteoglycans," or SLRPs) lumican and decorin are thought to be involved in the regulation of collagen fibril assembly. Preparation of these proteoglycans in chemical amounts without
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96751e467a561f2170c338a1c262f16d
https://doi.org/10.1007/s000180050048
https://doi.org/10.1007/s000180050048
Autor:
Diane E. Mechling, Peter J. Neame, Hans Peter Bächinger, Yanwen Chen, Ruedi Aebersold, Nicholas P. Morris, Jay E. Gambee, Kate E. Gregory, Julia Thom Oxford, Steven P. Gygi
Publikováno v:
Journal of Biological Chemistry. 275:11498-11506
Collagen XI is a heterotrimeric molecule found predominantly in heterotypic cartilage fibrils, where it is involved in the regulation of fibrillogenesis. This function is thought to involve the complex N-terminal domain. The goal of this current stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ea3a535ff8d1183a4371a617864a01
https://doi.org/10.1074/jbc.275.15.11498
https://doi.org/10.1074/jbc.275.15.11498
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1446:193-202
Cartilage is a tissue that is primarily extracellular matrix, the bulk of which consists of proteoglycan aggregates constrained within a collagen framework. Candidate components that organize the extracellular assembly of the matrix consist of collag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c157b95f4315992e78f7e887b98bacc
https://doi.org/10.1016/s0167-4781(99)00087-1
https://doi.org/10.1016/s0167-4781(99)00087-1
Publikováno v:
Journal of Biological Chemistry. 273:23469-23475
The cDNA cloning and expression in vitro and in eukaryotic cells of a novel protein isolated from human articular cartilage, cartilage intermediate layer protein (CILP) is described. A single 4. 2-kilobase mRNA detected in human articular cartilage e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421f9be9fc7a08d09ad68dfa333a9f52
https://doi.org/10.1074/jbc.273.36.23469
https://doi.org/10.1074/jbc.273.36.23469
Publikováno v:
Carbohydrate Research. 284:223-228
Hypertrophic scarring is characterized by disordered collagen fibrils. In order to determine whether this is, in part, a result of changes in the population of proteoglycans that are thought to be involved in regulation of collagen fibril formation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfce89251f1dcfac388d956ff899420
https://doi.org/10.1016/0008-6215(95)00403-3
https://doi.org/10.1016/0008-6215(95)00403-3
Publikováno v:
Journal of Virology. 70:600-606
ORF-2, a 32-kDa viral protein expressed by herpesvirus saimiri-transformed lymphocytes, is essential for transformation and is expressed on the plasma membrane of transformed cells. The current work now shows that most (approximately 80%) of ORF-2 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c2df729640fc5318e542bc2e1be096
https://doi.org/10.1128/jvi.70.1.600-606.1996
https://doi.org/10.1128/jvi.70.1.600-606.1996