Zobrazeno 1 - 10
of 309
pro vyhledávání: '"Peter J. Murray"'
Autor:
J. Josephine Botsch, Roswitha Junker, Michèle Sorgenfrei, Patricia P. Ogger, Luca Stier, Susanne von Gronau, Peter J. Murray, Markus A. Seeger, Brenda A. Schulman, Bastian Bräuning
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 struct
Externí odkaz:
https://doaj.org/article/83b8992d9946492ea98c04163ae4e8c3
Autor:
Peter J. Murray, Timothy D. Nevard
Publikováno v:
Animals, Vol 14, Iss 11, p 1576 (2024)
We explored the ecological and historical factors that led to formation of the unique guild of native and introduced mammalian herbivores between 5 and 1000 kg in northern Australia. Following the disappearance of large native herbivores about 46 kya
Externí odkaz:
https://doaj.org/article/f03aafe4b00645b8ac1fb787606ec774
Autor:
Christiane Desel, Peter J. Murray, Christian H. K. Lehmann, Lukas Heger, Dennis Christensen, Peter Andersen, Matthias Mack, Diana Dudziak, Roland Lang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Successful subunit vaccination with recombinant proteins requires adjuvants. The glycolipid trehalose-dibehenate (TDB), a synthetic analog of the mycobacterial cord factor, potently induces Th1 and Th17 immune responses and is a candidate adjuvant fo
Externí odkaz:
https://doaj.org/article/e3f89c8623f14ba7b25fd2abe6e24b5c
Autor:
Boyang Hua, Christopher P. Jones, Jaba Mitra, Peter J. Murray, Rebecca Rosenthal, Adrian R. Ferré-D’Amaré, Taekjip Ha
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Many RNAs become functional before their synthesis completes. Here the authors employ a single-molecule vectorial folding assay mimicking RNA transcription and show that the ZTP riboswitch is kinetically controlled and activated by slower unwinding a
Externí odkaz:
https://doaj.org/article/cd9a444440f54f6dbaa2b5c8d83e460c
Autor:
Julia S. Brunner, Loan Vulliard, Melanie Hofmann, Markus Kieler, Alexander Lercher, Andrea Vogel, Marion Russier, Johanna B. Brüggenthies, Martina Kerndl, Victoria Saferding, Birgit Niederreiter, Alexandra Junza, Annika Frauenstein, Carina Scholtysek, Yohei Mikami, Kristaps Klavins, Gerhard Krönke, Andreas Bergthaler, John J. O’Shea, Thomas Weichhart, Felix Meissner, Josef S. Smolen, Paul Cheng, Oscar Yanes, Jörg Menche, Peter J. Murray, Omar Sharif, Stephan Blüml, Gernot Schabbauer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Multinucleated giant cells (MGCs) are important in the pathogenesis of various diseases. Here, the authors demonstrate that extracellular presence of the amino acid arginine is required for MGC formation and metabolism, suggesting a translational imp
Externí odkaz:
https://doaj.org/article/28055bd4c7454a9b869483a12530bfc2
Publikováno v:
Animals, Vol 12, Iss 7, p 872 (2022)
Koalas are facing many threats and have now been officially listed as endangered. Recently, concerns were raised in anecdotal reports of koalas being killed by livestock, especially cattle. We investigated the significance of cattle as a threat to ko
Externí odkaz:
https://doaj.org/article/2ede572e4eaf4752901796230bd4fc64
Autor:
Alessandra Fiore, Stefano Ugel, Francesco De Sanctis, Sara Sandri, Giulio Fracasso, Rosalinda Trovato, Silvia Sartoris, Samantha Solito, Susanna Mandruzzato, Fulvia Vascotto, Keli L. Hippen, Giada Mondanelli, Ursula Grohmann, Geny Piro, Carmine Carbone, Davide Melisi, Rita T. Lawlor, Aldo Scarpa, Alessia Lamolinara, Manuela Iezzi, Matteo Fassan, Silvio Bicciato, Bruce R. Blazar, Ugur Sahin, Peter J. Murray, Vincenzo Bronte
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Signaling and transcriptional regulation of MDSC activity remains largely undefined. Here the authors show that monocytic MDSC immunosuppression is triggered by c-FLIP and requires NFκB, implicate this axis in cancer prognosis and response to therap
Externí odkaz:
https://doaj.org/article/c988a8bcde8c4a15aa07366b491c041d
Autor:
Lauren M. F. Merlo, James B. DuHadaway, James D. Montgomery, Wei-Dan Peng, Peter J. Murray, George C. Prendergast, Andrew J. Caton, Alexander J. Muller, Laura Mandik-Nayak
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Indoleamine-2,3-dioxygenase (IDO)1 and IDO2 are two closely related tryptophan catabolizing enzymes encoded by linked genes. The IDO pathway is also immunomodulatory, with IDO1 well-characterized as a mediator of tumor immune evasion. Due to its homo
Externí odkaz:
https://doaj.org/article/564df2743520466b8950a559dcc7cf6e
Publikováno v:
Animals, Vol 11, Iss 9, p 2684 (2021)
Koala populations in Australia are declining due to threats such as chlamydiosis, wild dog predation and vehicle collision. In the last decade, grazing livestock emerged anecdotally as a threat to koala survival in areas where koala habitat and lives
Externí odkaz:
https://doaj.org/article/16d40fe3a29f4f6b9911f506173a1e1f
Autor:
Susanne M. Steggerda, Mark K. Bennett, Jason Chen, Ethan Emberley, Tony Huang, Julie R. Janes, Weiqun Li, Andrew L. MacKinnon, Amani Makkouk, Gisele Marguier, Peter J. Murray, Silinda Neou, Alison Pan, Francesco Parlati, Mirna L. M. Rodriguez, Lee-Ann Van de Velde, Tracy Wang, Melissa Works, Jing Zhang, Winter Zhang, Matthew I. Gross
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-18 (2017)
Abstract Background Myeloid cells are an abundant leukocyte in many types of tumors and contribute to immune evasion. Expression of the enzyme arginase 1 (Arg1) is a defining feature of immunosuppressive myeloid cells and leads to depletion of L-argi
Externí odkaz:
https://doaj.org/article/e6521eae41ac406fb6124cdd07cf5f4d