Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Peter J. Meffin"'
Publikováno v:
Biological Mass Spectrometry. 4:42-47
Quantitative analytical procedures for the analysis of phenylbutazone and tolbutamide levels in plasma have been developed which involve the addition of deuterium labeled internal standards to plasma followed by extraction and direct sample insertion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64ece47726ed19a0d707cdcfa696f35b
https://doi.org/10.1002/bms.1200040105
https://doi.org/10.1002/bms.1200040105
Publikováno v:
The American Journal of Cardiology. 42:76-81
Right ventricular epicardial ventricular fibrillation threshold was determined during paced supraventricular rhythm using 100 hertz trains of stimuli at 15 minute intervals in dogs before, during and after a 90 minute infusion of tocainide, an orally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f14562e28695fb5178ec033e8797397
https://doi.org/10.1016/0002-9149(78)90988-8
https://doi.org/10.1016/0002-9149(78)90988-8
Autor:
Flora Peters, Peter J. Meffin, Donald C. Harrison, Roger A. Winkle, Edward W. Robert, Sandra R. Harapat
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 7:29-46
Plasma disopyramide concentration-time data and plasma protein binding measurements were obtained in 12 patients requiring disopyramide for suppression of their cardiac arrhythmias. The fraction of disopyramide unbound to plasma proteins varies from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cf2e6472eed7e848ebe9ae1592cdcd
https://doi.org/10.1007/bf01059439
https://doi.org/10.1007/bf01059439
Publikováno v:
Journal of Pharmacokinetics and Biopharmaceutics. 5:495-505
Four volunteers each received single oral doses of the R and S enantiomorphs of warfarin on separate occasions, both before and during clofibrate coadministration. Three of the subjects showed evidence for a drug interaction as manifested by an incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1306987bf6c394dfed402ec07a37cb
https://doi.org/10.1007/bf01061730
https://doi.org/10.1007/bf01061730
Publikováno v:
Journal of Chromatography A. 174:469-473
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ab8a1e7e28f29fcc58bd28a9b8307d
https://doi.org/10.1016/s0021-9673(00)86026-4
https://doi.org/10.1016/s0021-9673(00)86026-4
Publikováno v:
Journal of Chromatography A. 132:503-510
A high-pressure liquid chromatographic analysis for disopyramide (I) and its mono-N-dealkylated metabolite (II) in plasma and urine is described. The analysis, in which I and II together with an internal standard are chromatographed as ion pairs with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c74a9e4bbfa33267b562794ae8459d6
https://doi.org/10.1016/s0021-9673(00)82914-3
https://doi.org/10.1016/s0021-9673(00)82914-3
Publikováno v:
Clinical Pharmacology & Therapeutics. 20:290-299
The disposition of lidocaine and indocyanine green was studied in 6 individuals during and after recovery from an episode of acute viral hepatitis. Both compounds are highly cleared from the blood by the liver so that clearance of both should be sens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b344fe6e24e191b94b6776b63dd3913f
https://doi.org/10.1002/cpt1976203290
https://doi.org/10.1002/cpt1976203290
Publikováno v:
Thrombosis and Haemostasis. 39:466-473
SummaryA convenient, accurate and reproducible high pressure liquid chromatographic method for the quantitation of radio-labelled vitamin K1 and vitamin K1 epoxide in plasma is described. The method involves the determination of total ether extractab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e2dcc60f312fe65021d2fd13c5ebda
https://doi.org/10.1055/s-0038-1646706
https://doi.org/10.1055/s-0038-1646706
Publikováno v:
Clinical Pharmacology & Therapeutics. 22:557-567
The disposition of acebutolol has been studied following intravenous doses of 0.25 to 1.0 mg/kg in 9 healthy subjects using a specific chromatographic assay to determine concentrations of drug in blood. The mean blood clearance was 6.55 ml/min/kg and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67fc037a8a9b9f0ff2627aa88b9fb009
https://doi.org/10.1002/cpt1977225part1557
https://doi.org/10.1002/cpt1977225part1557
Publikováno v:
Clinical Pharmacology and Therapeutics. 27:230-235
Clofibrinic acid in saliva and plasma and its plasma protein binding were determined in 18 patients with renal impairment after a single 2-gm dose of clofibrate. A weak but significant correlation (r2 = 0.378; p < 0.02) between free plasma and saliva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::214dcd83c85a43f667b715c63ff1834b
https://doi.org/10.1038/clpt.1980.36
https://doi.org/10.1038/clpt.1980.36