Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Peter J. Lovell"'
An improved chromium(II)-mediated synthesis of E -alkenylstannanes from aldehydes using Bu 3 SnCHI 2 in DMF is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c300120b1850b7dab7e0093d021af6e
https://ora.ox.ac.uk/objects/uuid:0f3afd01-58bc-4620-b57c-f3cce117211f
https://ora.ox.ac.uk/objects/uuid:0f3afd01-58bc-4620-b57c-f3cce117211f
Autor:
Halina T Serafinowska, Claire M. Scott, Jeannette M. Watson, Kathryn R. Starr, Peter J. Lovell, Giancarlo Merlo, Frank E. Blaney, Paul W. Smith
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5581-5585
Novel 2-methyl-5-quinolinyl-1-piperazinylalkyl-3,4-dihydro-2H-1,4-benzoxazin-3-ones showing high affinities for the 5-HT1A/1B/1D receptors coupled with potent 5-HT reuptake inhibitory activity have been discovered. This is the first report describing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a37202e909d0db16f37c7cbfa2751d
https://doi.org/10.1016/j.bmcl.2008.08.110
https://doi.org/10.1016/j.bmcl.2008.08.110
Autor:
Peter J. Lovell, W. Russell Bowman, Graeme B. S. Potts, Mark R. J. Elsegood, Anthony J. Fletcher, Jan M. Pedersen, Elena Hernández López, Vickie McKee
Publikováno v:
Tetrahedron. 63:191-203
Amides have been successfully used as precursors of imidoyl radicals for radical cyclisation. The amides have been converted to imidoyl selanides via reaction with phosgene to yield imidoyl chlorides followed by reaction with potassium phenylselanide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb4d6f43a041c6eba4db2022939ecbb
https://doi.org/10.1016/j.tet.2006.10.030
https://doi.org/10.1016/j.tet.2006.10.030
Autor:
Jan M. Pedersen, W. Russell Bowman, Peter J. Lovell, Mark R. J. Elsegood, and Anthony J. Fletcher
Publikováno v:
The Journal of Organic Chemistry. 70:10615-10618
[reaction: see text] Imidoyl selanides, synthesized from amides, have been used as radical precursors of imidoyl radicals in cascade reactions. The novel radical cascade has been developed for the simple synthesis of the medicinally important aryl-an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf1ff8868b7ec7c6ce4cedb171b606c
https://doi.org/10.1021/jo0519920
https://doi.org/10.1021/jo0519920
Publikováno v:
Synlett. 2004:1905-1908
Imidoyl radicals, generated from imidoyl phenylselanide precursors, have been used for the synthesis of 2,3-disubstituted indoles. A facile high yielding synthesis of imidoyl phenylselanides has been developed. The potential for neophyl rearrangement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aa7622b2a3d8808eb891c608bdebf67
https://doi.org/10.1055/s-2004-830868
https://doi.org/10.1055/s-2004-830868
Publikováno v:
Tetrahedron. 60:5085-5092
The nucleophilic addition of ethyl 3-propionylzinc iodide to a variety of differently protected pentopyranose derived d -glycals 6a–g proceeds with good to high levels of diastereoselectivity to provide the corresponding β-C-glycosides 7 . The ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaac8c0a68747fe9606e86219c40526
https://doi.org/10.1016/j.tet.2004.04.004
https://doi.org/10.1016/j.tet.2004.04.004
Autor:
Halina T Serafinowska, Helen Newman, Frank D. King, Douglas R Smith, Stephen E. Clarke, Graham J. Riley, Steven Mark Bromidge, Peter J. Lovell, David R. Thomas, Carol Routledge
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:1357-1360
The synthesis of novel 3-(octahydropyrido[1,2-a]pyrazin-2-yl)- and 3-(hexahydropyrrolo[1,2-a]pyrazin-2-yl)phenyl-2-benzo[b]thiophene sulphonamide derivatives 3, (S)-4 and (R)-4 is described. The compounds show high affinity for the 5-HT6 receptor, ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9097d1a47d7ae40cf0adc9f34cd5851d
https://doi.org/10.1016/s0960-894x(02)00172-5
https://doi.org/10.1016/s0960-894x(02)00172-5
Autor:
Peter J. Lovell, Jim J. Hagan, Graham J. Riley, David R. Piper, Nigel Deeks, Derek N. Middlemiss, Andrew D. Medhurst, Tania O. Stean, Phillip Jeffrey, Neil Upton, Martin I. Smith, David R. Thomas, Gary W. Price, Steven Mark Bromidge
Publikováno v:
British Journal of Pharmacology. 130:539-548
The novel 5-HT7 receptor antagonist, SB-269970-A, potently displaced [3H]-5-CT from human 5-HT7(a) (pKi 8.9±0.1) and 5-HT7 receptors in guinea-pig cortex (pKi 8.3±0.2). 5-CT stimulated adenylyl cyclase activity in 5-HT7(a)/HEK293 membranes (pEC50 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14a226fd690bd3cf1d60876f0e5b54a5
https://doi.org/10.1038/sj.bjp.0703357
https://doi.org/10.1038/sj.bjp.0703357
Autor:
Jim J. Hagan, Peter J. Atkinson, Michael Ho, Peter J. Lovell, David R. Thomas, Gary W. Price, Steven Mark Bromidge, Derek N. Middlemiss, Anthony J Villani
Publikováno v:
British Journal of Pharmacology. 130:409-417
Binding of the 5-HT7 receptor antagonist radioligand [3H]-SB-269970 to human 5-HT7(a) receptors expressed in HEK293 cell membranes (h5-HT7(a)/293) and to guinea-pig cerebral cortex membranes, was characterized and compared with [3H]-5-CT binding. [3H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92ab1086de749d83e8bf93b02c6068bb
https://doi.org/10.1038/sj.bjp.0703318
https://doi.org/10.1038/sj.bjp.0703318
Autor:
David J. Williams, Stephen C. Smith, Peter J. Lovell, Alexandra M. Z. Slawin, Steven V. Ley, Wood Anthony
Publikováno v:
Tetrahedron. 49:1675-1700
The synthesis of a novel macrocyclic carbonate (5) is described which undergoes a base mediated retro-Aldol reaction to cleave the C8C14 bond giving the highly functionalised decalin unit (7). This key reaction has allowed the preparation of furth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e98a4cdb2ba3465d17a1a9bcad2ad38e
https://doi.org/10.1016/s0040-4020(01)80354-9
https://doi.org/10.1016/s0040-4020(01)80354-9