Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Peter J. Lockyer"'
Autor:
Yanfeng Dai, Edwin C.J.M. de Vet, Peter J. Lockyer, Simon J. Cook, Heidi C.E. Welch, Simon Walker
Publikováno v:
Journal of Biological Chemistry. 286:19905-19916
CAPRI is a member of the GAP1 family of GTPase-activating proteins (GAPs) for small G proteins. It is known to function as an amplitude sensor for intracellular Ca(2+) levels stimulated by extracellular signals and has a catalytic domain with dual Ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dafb24b9728ffecda51fe77828e4aafc
https://doi.org/10.1074/jbc.m110.201301
https://doi.org/10.1074/jbc.m110.201301
Autor:
Sabine Kupzig, Takashi Tsuboi, Trever G. Bivona, Peter J. Lockyer, Louise C Davies, Maxine J. Allen, Gyles E. Cozier, Guy A. Rutter, Peter J. Cullen, Simon Walker, Alan Buckler, Dalila Bouyoucef, Mark R. Philips
Publikováno v:
The EMBO Journal. 23:1749-1760
Receptor-mediated increases in the concentration of intracellular free calcium ([Ca2+]i) are responsible for controlling a plethora of physiological processes including gene expression, secretion, contraction, proliferation, neural signalling, and le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ac714461fbc31235b3dac9a815998c
https://doi.org/10.1038/sj.emboj.7600197
https://doi.org/10.1038/sj.emboj.7600197
Autor:
Angel Pellicer, Theresa M. Grana, Mark R. Philips, Ignacio Pérez de Castro, Peter J. Lockyer, Peter J. Cullen, Trever G. Bivona, Vi K. Chiu, Adrienne D. Cox, Ian M. Ahearn
Publikováno v:
Nature. 424:694-698
Ras proteins regulate cellular growth and differentiation, and are mutated in 30% of cancers. We have shown recently that Ras is activated on and transmits signals from the Golgi apparatus as well as the plasma membrane but the mechanism of compartme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35689974c9f772d74f4944aca3fab73
https://doi.org/10.1038/nature01806
https://doi.org/10.1038/nature01806
Autor:
Peter J. Lockyer, Peter J. Cullen
Publikováno v:
Nature Reviews Molecular Cell Biology. 3:339-348
Calcium is a universal intracellular signal that is responsible for controlling a plethora of cellular processes. Understanding how such a simple ion can regulate so many diverse cellular processes is a key goal of calcium- and cell-biologists. One m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac166e0b841a40a47f4506e4f57d36dc
https://doi.org/10.1038/nrm808
https://doi.org/10.1038/nrm808
Publikováno v:
Biochemical Journal. 359:119-127
Tumour necrosis factor-α (TNF-α) may activate both cell survival and cell death pathways. In the murine fibrosarcoma cell line WEHI-164, physiological concentrations (1ng/ml) of TNF-α induced wortmannin-sensitive cell ruffling characteristic of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8503080726aabad54c8182dcf3132b45
https://doi.org/10.1042/bj3590119
https://doi.org/10.1042/bj3590119
Autor:
Peter J. Lockyer, Stefan Wennström, Kanamarlapudi Venkateswarlu, Julian Downward, Sabine Kupzig, Peter J. Cullen
Publikováno v:
Current Biology. 9:265-269
GAP1(m) is a member of the GAP1 family of Ras GTPase-activating proteins (GAPs) [1]. In vitro, it has been shown to bind inositol 1, 3,4,5-tetrakisphosphate (IP4), the water-soluble inositol head group of the lipid second messenger phosphatidylinosit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2da0759433f3492e1949d49164c2751
https://doi.org/10.1016/s0960-9822(99)80116-x
https://doi.org/10.1016/s0960-9822(99)80116-x
Autor:
Sara Vanlingen, Robin F. Irvine, Jan B. Parys, Peter J. Lockyer, Jon S. Reynolds, Tracy J. McNulty, Peter J. Cullen
Publikováno v:
Biochemical and Biophysical Research Communications. 255:421-426
GAP1 IP4BP and GAP1 m belong to the GAP1 family of Ras GTPase-activating proteins that are candidate InsP 4 receptors. Here we show they are ubiquitously expressed in human tissues and are likely to have tissue-specific splice variants. Analysis by s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8c847ff16859a6a5e457dd475d33c0
https://doi.org/10.1006/bbrc.1999.0217
https://doi.org/10.1006/bbrc.1999.0217
Publikováno v:
Biochemical and Biophysical Research Communications. 250:143-149
Previously we have purified and cloned a high affinity isomerically specific inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P 4 )-binding protein which, because it is clearly a member of the GAP1 family of Ras GTPase-activating proteins (GAP), we ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62424d7fb68da784119cc16261b99df9
https://doi.org/10.1006/bbrc.1998.9179
https://doi.org/10.1006/bbrc.1998.9179
Autor:
Anthony G. Lee, Elena Puente, J. Malcolm East, Peter J. Lockyer, Fergus Gerard Paul Earley, John David Windass
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1369:14-18
A complementary DNA for the Tobacco Budworm, Heliothis virescens, sarco(endo)plasmic reticulum-type Ca(2+)-ATPase (HVSERCA) has been cloned and sequenced. cDNA fragments of adult rabbit fast-twitch muscle Ca(2+)-ATPase (SERCA1a) were used as heterolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436b252449fc0f14deca2b085b322b8b
https://doi.org/10.1016/s0005-2736(97)00247-2
https://doi.org/10.1016/s0005-2736(97)00247-2
Autor:
Peter J. Lockyer, Simon J. Cook
Publikováno v:
Cell calcium. 39(2)
Our understanding of the mechanisms whereby growth factors stimulate cell proliferation through the Ras pathway stems largely from studies of the canonical pathway involving recruitment of Ras activators and inhibitors to the vicinity of receptor tyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8b6f5b50941f4f43cf28ff4baa6fa2
https://pubmed.ncbi.nlm.nih.gov/16343616
https://pubmed.ncbi.nlm.nih.gov/16343616