Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Peter J. L. Lane"'
Autor:
Yasir S Elhassan, Wiebke Arlt, Alberto S Tresoldi, Miriam Asia, Konstantinos N. Manolopoulos, Michael W. O’Reilly, Steven Watkins, Peter J. L. Lane, Shireen S Velangi, Mona Elshafie
Publikováno v:
Endocrine Abstracts.
Autor:
Paul Ellis, Simon Ameer-Beg, Sarah E Pinder, Simon P. Poland, Rachel Evans, Cheryl Gillett, David R. Withers, Frank McCaughan, Leo M. Carlin, Sheeba Irshad, Patrick Gordon, Uzma Hasan, Dominic Patel, Sergio A. Quezada, Tony Ng, Anita Grigoriadis, Stewart G. Martin, Felix Wong, Julie Owen, Natalie Woodman, Katherine Lawler, Anthony Cheung, Borivoj Vojnovic, Manuel Rodriguez-Justo, Paul R. Barber, Gilbert O. Fruhwirth, Patrycja Gazinska, Victoria Male, Peter J. L. Lane, Fabian Flores-Borja, Andrew Tutt, Farzana Noor, James Monypenny
Publikováno v:
Irshad, S, Flores-Borja, F, Lawler, K, Monypenny, J, Evans, R, Male, V, Gordon, P, Cheung, A, Gazinska, P, Noor, F, Wong, F, Grigoriadis, A, Fruhwirth, G O, Barber, P R, Woodman, N, Patel, D, Rodriguez-Justo, M, Owen, J, Martin, S G, Sarah, E P, Cheryl, E G, Poland, S P, Ameer-Beg, S, McCaughan, F, Carlin, L M, Hasan, U, Withers, D R, Lane, P, Vojnovic, B, Quezada, S A, Ellis, P, Tutt, A N J & Ng, T 2017, ' RORγt + innate lymphoid cells promote lymph node metastasis of breast cancers ', Cancer Research, vol. 77, no. 5, pp. 1083-1096 . https://doi.org/10.1158/0008-5472.CAN-16-0598
Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor microenvironment (TME), the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c12353ce206bad7e076bc88766252d3
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
https://kclpure.kcl.ac.uk/ws/files/62873523/Revised_Manuscript_Final.pdf
The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development
Autor:
William E. Jenkinson, Jennifer E. Cowan, Eric J. Jenkinson, Peter J. L. Lane, Sonia M. Parnell, Graham Anderson, Kyoko Nakamura, Jorge Caamano
Publikováno v:
The Journal of Experimental Medicine
The thymic medulla and an intact mTEC compartment are needed for the development of nTreg cells and negative selection of conventional T cells but not their further maturation.
A key role of the thymic medulla is to negatively select autoreactiv
A key role of the thymic medulla is to negatively select autoreactiv
Autor:
Graham Anderson, Clare L. Marriott, Ewan A. Ross, Adriana Flores-Langarica, David R. Withers, Emma C. Mackley, Peter J. L. Lane, Guillaume E. Desanti, Andrea J. White, Natalie A. Roberts, Fabrina Gaspal, Fiona M. McConnell
Publikováno v:
The Journal of Immunology. 189:2094-2098
Phylogeny shows that CD4 T cell memory and lymph nodes coevolved in placental mammals. In ontogeny, retinoic acid orphan receptor (ROR)γ-dependent lymphoid tissue inducer (LTi) cells program the development of mammalian lymph nodes. In this study, w
Autor:
Graham Anderson, Fabrina Gaspal, Peter J. L. Lane, Mi-Yeon Kim, David R. Withers, Fiona M. McConnell
Publikováno v:
Annals of the New York Academy of Sciences. 1247:1-15
Lymphoid tissue inducer cells (LTi) are a relatively new arrival on the immunological cellular landscape, having first been characterized properly only 15 years ago. They are members of an emerging family of innate lymphoid cells (ILCs). Elucidation
Autor:
Eric J. Jenkinson, Laetitia Gautreau-Rolland, Graham Anderson, Amine Boudil, Guillaume E. Desanti, Sonia M. Parnell, Sophie Ezine, Peter J. L. Lane, Bertus Eksteen, William E. Jenkinson
Publikováno v:
The Journal of Immunology. 186:5227-5235
The entry of T cell progenitors to the thymus marks the beginning of a multistage developmental process that culminates in the generation of self–MHC-restricted CD4+ and CD8+ T cells. Although multiple factors including the chemokine receptors CCR7
Autor:
Vasileios Bekiaris, Fiona M. McConnell, Hideo Yagita, Fabrina Gaspal, Graham Anderson, Manoj Saini, Mahmood Khan, David R. Withers, Andrea J. White, Peter J. L. Lane, Lucy S. K. Walker
Publikováno v:
The Journal of Experimental Medicine
FoxP3-deficient mice are rescued from tissue and organ destruction and subsequent lethal autoimmune disease by the combined absence of OX40 and CD30 signals.
Our previous studies have implicated signaling through the tumor necrosis family recept
Our previous studies have implicated signaling through the tumor necrosis family recept
Autor:
Roger Bird, Adam F. Cunningham, Ian C. M. MacLennan, Karine Serre, Peter J. L. Lane, Elodie Mohr, Fabrina Gaspal
Publikováno v:
Molecular Immunology. 47:1914-1922
While IL-4 directs CD4 T cells to produce Th2 cytokines (including IL-4, IL-13, IL-5) in vitro it has been shown that production of these cytokines can be induced in vivo in the absence of IL-4/IL-13/STAT-6 signaling. The present report shows that CD
Autor:
Stefan G. Hubscher, Dimitris Velissaris, Chundamannil E. Eapen, Elwyn Elias, Timothy Plant, Peter J. L. Lane, Peter Nightingale
Publikováno v:
Digestive Diseases and Sciences. 56:227-235
Non-cirrhotic intrahepatic portal hypertension (NCIPH) is generally regarded to have a benign prognosis. We have studied a cohort followed-up at a tertiary referral center and postulate that gut-derived prothrombotic factors may contribute to the pat
Autor:
David R. Withers, Elin Jaensson, William W. Agace, Fabrina Gaspal, Graham Anderson, Peter J. L. Lane, Bertus Eksteen, Fiona M. McConnell
Publikováno v:
The Journal of Immunology. 183:5079-5084
Although CD4+ memory T cells reside within secondary lymphoid tissue, the major reservoir of these cells is in the lamina propria of the intestine. In this study, we demonstrate that, in the absence of signals through both OX40 and CD30, CD4+ T cells