Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Peter J. Koch"'
Autor:
Peter J. Koch, Maranke I. Koster
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
The last decade has seen a dramatic increase in innovative ideas for the treatment of genetic disorders for which no curative therapies exist. Gene and protein replacement therapies stand out as novel approaches to treat a select group of these disea
Externí odkaz:
https://doaj.org/article/96bdcba5ddd34516aa122bb788d27607
Publikováno v:
Dermatology Research and Practice, Vol 2010 (2010)
Three related proteins of the plakophilin family (PKP1_3) have been identified as junctional proteins that are essential for the formation and stabilization of desmosomal cell contacts. Failure of PKP expression can have fatal effects on desmosomal a
Externí odkaz:
https://doaj.org/article/2077f4edca84465094c39a561f7cc28d
Publikováno v:
Dermatology Research and Practice, Vol 2010 (2010)
Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mut
Externí odkaz:
https://doaj.org/article/eaf38f603f2c4c76bd7538336f06d266
Publikováno v:
Dermatology Research and Practice, Vol 2010 (2010)
Externí odkaz:
https://doaj.org/article/866df4b5fffe471e89333c6ee22cd974
Autor:
Maddison N. Salois, Jessica A. Gugger, Saiphone Webb, Christina E. Sheldon, Shirley P. Parraga, G. Michael Lewitt, Dorothy K. Grange, Peter J. Koch, Maranke I. Koster
Publikováno v:
bioRxiv
The goal of this study was to investigate the molecular mechanisms responsible for the formation of skin erosions in patients affected by Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome (AEC). This ectodermal dysplasia is caused by mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc838e53f3faa03317137359ff5924a0
https://europepmc.org/articles/PMC10187256/
https://europepmc.org/articles/PMC10187256/
Autor:
Raphael A. Nemenoff, Mark Geraci, Paul A. Bunn, Lynn Heasley, Roger Powell, Timothy C. Kennedy, Greg Hickey, Anna E. Baron, Xian Lu, David J. Orlicky, Christopher Coldren, Charlene O'Shea, Peter J. Koch, Storey Wilson, Adrie van Bokhoven, Jessica M. Malloy, Elizabeth J. Donald, Mary C. O'Keefe, Meredith A. Tennis, Lori D. Dwyer-Nield, Micah B. Friedman, York E. Miller, Robert L. Keith, Michio Sugita, Wilbur A. Franklin, Michael G. Edwards, Daniel T. Merrick
Persistent bronchial dysplasia is associated with increased risk of developing invasive squamous cell carcinoma (SCC) of the lung. In this study, we hypothesized that differences in gene expression profiles between persistent and regressive bronchial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea91707d0c49730f588b90ad933b0c7
https://doi.org/10.1158/0008-5472.c.6512359.v1
https://doi.org/10.1158/0008-5472.c.6512359.v1
Autor:
Raphael A. Nemenoff, Mark Geraci, Paul A. Bunn, Lynn Heasley, Roger Powell, Timothy C. Kennedy, Greg Hickey, Anna E. Baron, Xian Lu, David J. Orlicky, Christopher Coldren, Charlene O'Shea, Peter J. Koch, Storey Wilson, Adrie van Bokhoven, Jessica M. Malloy, Elizabeth J. Donald, Mary C. O'Keefe, Meredith A. Tennis, Lori D. Dwyer-Nield, Micah B. Friedman, York E. Miller, Robert L. Keith, Michio Sugita, Wilbur A. Franklin, Michael G. Edwards, Daniel T. Merrick
Supplemental table S1 documents comparability between final groupings of baseline biopsies used for gene expression comparisons between persistent and regressive sites demonstrating comparability in all key histologic and clinical variables with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50980f3916c13cb411e1361af5b422aa
https://doi.org/10.1158/0008-5472.22426510
https://doi.org/10.1158/0008-5472.22426510
Publikováno v:
Current Protocols. 2
Investigating basic biological mechanisms underlying human diseases relies on the availability of sufficient quantities of patient cells. As most primary somatic cells have a limited lifespan, obtaining sufficient material for biological studies has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d1054506d844cc06793407fd1c16d5
https://doi.org/10.1002/cpz1.408
https://doi.org/10.1002/cpz1.408
Autor:
Maranke I Koster, Peter J Koch
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Frontiers in Genetics
Frontiers in Genetics
The last decade has seen a dramatic increase in innovative ideas for the treatment of genetic disorders for which no curative therapies exist. Gene and protein replacement therapies stand out as novel approaches to treat a select group of these disea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbde6651311f31f6a70ac1be27aba17b
https://www.frontiersin.org/articles/10.3389/fgene.2021.714764/full
https://www.frontiersin.org/articles/10.3389/fgene.2021.714764/full
Publikováno v:
Volume 4: Heat Transfer, Parts A and B.
As part of a thorough benchmarking of the baseline cooling design in planned optimization work, Reynolds-Averaged Navier Stokes (RANS) conjugate heat transfer (CHT) computational fluid dynamics (CFD) assessments have been accomplished at RTV design f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26c48017a42673151d7df9729569a737
https://doi.org/10.1115/gt2012-68065
https://doi.org/10.1115/gt2012-68065