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pro vyhledávání: '"Peter J. Kilford"'
Autor:
Peter J. Kilford, Kuan‐Fu Chen, Kim Crewe, Iain Gardner, Oliver Hatley, Alice Ban Ke, Sibylle Neuhoff, Mian Zhang, Karen Rowland Yeo
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 7, Pp 822-832 (2022)
Abstract Physiologically‐based pharmacokinetic (PBPK) modeling is being increasingly used in drug development to avoid unnecessary clinical drug–drug interaction (DDI) studies and inform drug labels. Thus, regulatory agencies are recommending, or
Externí odkaz:
https://doaj.org/article/5516ed2a72b542b39b08ffd22bd4d60c
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 47(4)
Due to health authority warnings and the recommended limited use of ketoconazole as a model inhibitor of cytochrome P450 (CYP) 3A4 in clinical drug-drug interaction (DDI) studies, there is a need to search for alternatives. Ritonavir is a strong inhi
Publikováno v:
Drug Metabolism and Disposition. 36:535-542
Two predictive tools have been proposed by Austin et al. (Drug Metab Dispos 30:1497-1503, 2002) and Hallifax and Houston (Drug Metab Dispos 34:724-726, 2006) to estimate the fraction unbound in the incubation (fu(inc)). The current study was undertak
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 37(1)
Glucuronidation via UDP-glucuronosyltransferase (UGT) is an increasingly important clearance pathway. In this study intrinsic clearance (CL(int)) values for buprenorphine, carvedilol, codeine, diclofenac, gemfibrozil, ketoprofen, midazolam, naloxone,
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 36(7)
Analogous to the fraction unbound in microsomes (fu(mic)), fraction unbound in hepatocyte incubations (fu(hep)) is an important parameter in the prediction of intrinsic clearance and potential drug-drug interactions. A recent study by Austin et al. (