Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Peter J. Johnston"'
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 58:410-419
Purpose Poly(ADP-ribose) polymerase-1 (PARP-1) is rapidly and directly activated by single-strand breaks and is required for efficient base excision repair. These properties indicate that inhibition of PARP-1 might enhance the cellular response to lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::304641cb6182577258faf41a21fb0b9a
https://doi.org/10.1016/j.ijrobp.2003.09.053
https://doi.org/10.1016/j.ijrobp.2003.09.053
Autor:
Arusha Oloumi, Chenmei Luo, Judit P. Banáth, Susan H. MacPhail, Peggy L. Olive, Peter J. Johnston
Publikováno v:
Experimental Cell Research. 243:282-289
When exposed to etoposide, the outer cells from Chinese hamster V79 spheroids are about 10 times more resistant to DNA strand breaks and cell killing than V79 cells grown as monolayers. Previous results have shown that the outer cells of both spheroi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73170d897bd894d181b58663f9c5b6f4
https://doi.org/10.1006/excr.1998.4170
https://doi.org/10.1006/excr.1998.4170
Autor:
Peter J. Johnston, Peter E. Bryant
Publikováno v:
Mutation Research/Genetic Toxicology. 299:289-296
Restriction endonucleases (RE) can be used to mimic and model the clastogenic effects of ionising radiation. With the development of improved techniques for cell poration: electroporation and recently streptolysin O (SLO), it has become possible more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::751ac5989aa432bf4b40376712ff8920
https://doi.org/10.1016/0165-1218(93)90105-m
https://doi.org/10.1016/0165-1218(93)90105-m
Publikováno v:
Neuro-oncology. 9(4)
We examined DNA damage responses and repair in four human glioma cell lines (A7, U87, T98G, and U373) and normal human astrocytes (NHAs) after clinically relevant radiation doses to establish whether we could identify differences among them that migh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acaa4d013b95aea4abeb71dd0557de38
https://pubmed.ncbi.nlm.nih.gov/17704360
https://pubmed.ncbi.nlm.nih.gov/17704360
Publikováno v:
Radiation research. 167(4)
Nitric oxide was shown to radiosensitize anoxic V79 and CHO hamster cells and MCF7 and UT-SCC-14 human cells, measuring clonogenic survival and/or DNA damage in vitro at low radiation doses (0.1-5 Gy). Radiosensitization was easily detected after 2 G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc7d692d5fdd9da5b85d61cef65c2d85
http://ora.ox.ac.uk/objects/uuid:c404641f-6dee-4e6d-9f85-72418c324d1e
http://ora.ox.ac.uk/objects/uuid:c404641f-6dee-4e6d-9f85-72418c324d1e
Publikováno v:
Nature Medicine. 4:103-105
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14893b545139e3270e5b8c5afbea5fd
https://doi.org/10.1038/nm0198-103
https://doi.org/10.1038/nm0198-103
Autor:
Peter J. Johnston, George D. Wilson
We have shown that cell lethality actually measured after exposure to low-doses of low-LET radiation, is markedly enhanced relative to the cell lethality previously expected by extrapolation of the high-dose cell-killing response. Net cancer risk is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68bb8fb6212c57e1ba70742556372c4c
https://doi.org/10.2172/816335
https://doi.org/10.2172/816335
Publikováno v:
Radiation research. 159(3)
Redpath, J. L., Short, S. C., Woodcock, M. and Johnston, P. J. Low-Dose Reduction in Transformation Frequency Compared to Unirradiated Controls: The Role of Hyper-radiosensitivity to Cell Death. Radiat. Res. 159, 433–436 (2003). Calculations based
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::733f098256df5d7e58837821c105a573
https://pubmed.ncbi.nlm.nih.gov/12600247
https://pubmed.ncbi.nlm.nih.gov/12600247
Publikováno v:
International journal of radiation biology. 78(12)
To investigate the role of DNA-dependent protein kinase (DNA-PK) in the phenomena of low dose hyper-radiosensitivity (HRS) and increased radioresistance (IRR) using the genetically related M059 cell lines of disparate PRKDC status.Clonogenic survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cdc5f8058a897c9d6348172079dbd1
https://pubmed.ncbi.nlm.nih.gov/12556341
https://pubmed.ncbi.nlm.nih.gov/12556341
Our overall aim is to gather understanding of the mechanisms underlying low-dose hyperradiosensitivity (HRS) and induced radioresistance (IRR). There is now some direct evidence that this dose-dependent radiosensitivity phenomenon reflects changes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d06274b43446e69e040e46e2e40f06e3
https://doi.org/10.2172/833483
https://doi.org/10.2172/833483