Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Peter J. Harvison"'
Autor:
Erica L. Kennedy, Nathan M. West, Randy J. Zauhar, Ruy Tchao, Douglas M. Frederick, Alyssa M. Keil, Erina Y. Jacinto, Peter J. Harvison
Publikováno v:
Toxicology in Vitro. 29:1887-1896
Liver damage occurred in some patients who took troglitazone (TGZ) for type II diabetes. The 2,4-thiazolidinedione (TZD) ring in TGZ's structure has been implicated in its hepatotoxicity. To further examine the potential role of a TZD ring in toxicit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e5ec6248e8bf9f203694b6ddeedd71
https://doi.org/10.1016/j.tiv.2015.07.015
https://doi.org/10.1016/j.tiv.2015.07.015
Publikováno v:
Journal of Applied Toxicology. 32:108-117
Glitazones, used for type II diabetes, have been associated with liver damage in humans. A structural feature known as a 2,4-thiazolidinedione (TZD) ring may contribute to this toxicity. TZD rings are of interest since continued human exposure via th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::163b1316aa290b7e4269068e6d40dd84
https://doi.org/10.1002/jat.1639
https://doi.org/10.1002/jat.1639
Autor:
Ruy Tchao, Peter J. Harvison, Erica L. Kennedy, Douglas M. Frederick, Niti N. Patel, Christine M. Crincoli
Publikováno v:
Xenobiotica. 38:435-449
1. The thiazolidinedione ring present in drugs available for type II diabetes can contribute to hepatic injury. Another thiazolidinedione ring-containing compound, 3-(3,5-dichlorophenyl)-2,4-thiazoli-dinedione (DCPT), produces liver damage in rats. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a323633b259c198f631fd95ecd620919
https://doi.org/10.1080/00498250701830267
https://doi.org/10.1080/00498250701830267
Publikováno v:
Toxicology. 186:79-91
Nephrotoxicity of the agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) in rats is believed to involve metabolism on the succinimide ring. To further investigate this hypothesis, we synthesized and tested the following NDPS analogues, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e31bdf3e678fb1ee8351ef97231ae7a
https://doi.org/10.1016/s0300-483x(02)00692-3
https://doi.org/10.1016/s0300-483x(02)00692-3
Autor:
Donghui Cui, Peter J. Harvison
Publikováno v:
Rapid Communications in Mass Spectrometry. 14:1985-1990
Derivatization using 3-pyridylcarbinol coupled with liquid chromatography electrospray ionization tandem mass spectrometry (LC/MS/MS) was used to characterize a novel Phase II metabolite of the nephrotoxic agricultural fungicide, N-(3,5-dichloropheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29c4e189b80231d340f98028485b1f0a
https://doi.org/10.1002/1097-0231(20001115)14:21<1985::aid-rcm122>3.0.co
https://doi.org/10.1002/1097-0231(20001115)14:21<1985::aid-rcm122>3.0.co
Publikováno v:
Toxicological Sciences. 37:117-124
The agricultural fungicide N-(3,5-dichlorophenyl)succinimide (NDPS) is nephrotoxic in rats. Previous studies have suggested that oxidative hepatic biotransformation is required for the induction of kidney damage. The experiments described in this pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1577d525468ec251911dd3be511146d
https://doi.org/10.1093/toxsci/37.2.117
https://doi.org/10.1093/toxsci/37.2.117
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4c60755ecf3f1744288f5235c67678
https://doi.org/10.1096/fasebj.27.1_supplement.1106.4
https://doi.org/10.1096/fasebj.27.1_supplement.1106.4
Autor:
Caroline M. Henesey, Peter J. Harvison
Publikováno v:
Toxicology. 104:9-16
N-(3,5-Dichlorophenyl)succinimide (NDPS) is an agricultural fungicide and antimicrobial agent that produces nephrotoxicity in rats. The contribution of the kidney, if any, to the mechanism of toxicity of NDPS is not known. Therefore, the ability of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a40d59c9f26c0883007a424dd7711e
https://doi.org/10.1016/0300-483x(95)03116-w
https://doi.org/10.1016/0300-483x(95)03116-w
Autor:
Thomas H. Rushmore, Peter J. Harvison, Niti N. Patel, Ruy Tchao, Douglas M. Frederick, Erina Y. Jacinto
The thiazolidinedione (TZD) ring is a constituent of the glitazones that are used to treat type II diabetes. Liver injury has been reported following chronic glitazone use; however, they do not produce hepatic damage in common laboratory animal speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68c6260dbf7c84978b438ee84d09548
https://europepmc.org/articles/PMC3386561/
https://europepmc.org/articles/PMC3386561/
Publikováno v:
Journal of applied toxicology : JAT. 32(2)
Glitazones, used for type II diabetes, have been associated with liver damage in humans. A structural feature known as a 2,4-thiazolidinedione (TZD) ring may contribute to this toxicity. TZD rings are of interest since continued human exposure via th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d366d35893c4a24cb418ae7f1340a97e
https://pubmed.ncbi.nlm.nih.gov/21337588
https://pubmed.ncbi.nlm.nih.gov/21337588