Výsledky vyhledávání - "Peter J. Feilen"

Mesenchymal stem cell (MSC)-mediated survival of insulin producing pancreatic β-cells during cellular stress involves signalling via Akt and ERK1/2

Autor: Leonie Lang, Weiwei Zhang, Christina Jäger, M Alt, Peter J. Feilen, Günter Päth, Chune Liu, Nikolaos Perakakis, Jochen Seufert, Katharina Laubner, J Straetener, Natia Peradze

Publikováno v: Molecular and cellular endocrinology. 473

Mesenchymal stem cells (MSC) are of interest for cell therapy since their secreted factors mediate immunomodulation and support tissue regeneration. This study investigated the direct humoral interactions between MSC and pancreatic β-cells using hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53cc4670fa94b366c4f19300aa0608e
https://pubmed.ncbi.nlm.nih.gov/29421520

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Real-time 3-D dark-field microscopy for the validation of the cross-linking process of alginate microcapsules

Autor: Marcus Behringer, Peter J. Feilen, M Weber, M. Salinas Jungjohann, Ernst Bamberg, Julio A. Vásquez, Matthias M. Weber, A. Steinbach, Heiko Zimmermann, L. Pließ, Dirk Zimmermann, Ulrich Zimmermann, Friederike Ehrhart, J. Spitz, Stephan Schneider, A. Katsen, P. Geßner, R. Wolf

Publikováno v: Biomaterials. 26:6386-6393

Alginate-based microencapsulation is a promising method for long-term maintenance of cellular and membrane function of the cells and tissue fragments required for in vitro and in vivo biosensors, for tissue engineering and particularly for immunoisol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045f50e3d9acc633db45be6c3efd435c
https://doi.org/10.1016/j.biomaterials.2005.04.015

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Towards a medically approved technology for alginate-based microcapsules allowing long-term immunoisolated transplantation

Publikováno v: Journal of Materials Science: Materials in Medicine. 16:491-501

The concept of encapsulated-cell therapy is very appealing, but in practice a great deal of technology and know-how is needed for the production of long-term functional transplants. Alginate is one of the most promising biomaterials for immunoisolati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d9b2061a386581f13756d1ec31ba0e
https://doi.org/10.1007/s10856-005-0523-2

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Radiosynthesis of 1-(4-(2-[18F]fluoroethoxy)benzenesulfonyl)-3-butyl urea: a potentialβ-cell imaging agent

Autor: Peter J. Feilen, Abass Alavi, Peter H. Kann, Alexander Schmitz, Stefan Schneider, Ralf Schirrmacher, Chyng-Yann Shiue, Marc Weber, Frank Rösch

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 45:763-774

Summary Tolbutamide (1) is a sulfonurea agent used to stimulate insulin secretion in type 2 diabetic patients. Its analogue 1-(4-(2-[ 18 F]fluoroethoxy)benzenesulfonyl)-3butyl urea (3) was synthesized in overall radiochemical yields of 45% as a poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::02b6a96d5095a6e39e9a51d42e34fed9
https://doi.org/10.1002/jlcr.599

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Multilayer capsules: a promising microencapsulation system for transplantation of pancreatic islets

Autor: Stephan Schneider, Rainer Pommersheim, Jürgen Beyer, Peter J. Feilen, Simon Preuss, Svend Berger, Viola Slotty, Daniel Kampfner

Publikováno v: Biomaterials. 22:1961-1970

In 1980, Lim and Sun introduced a microcapsule coated with an alginate/polylysine complex for encapsulation of pancreatic islets. Characteristic to this type of capsule is, that it consists of a plain membrane which is formed during a single procedur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed448fd408d9a7927012059c3eb9714d
https://doi.org/10.1016/s0142-9612(00)00380-x

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Magnetic separation of encapsulated islet cells labeled with superparamagnetic iron oxide nano particles

Autor: Esther Mettler, Heiko Zimmermann, Christian Fottner, Matthias M. Weber, Peter J. Feilen, Laura M. Schreiber, Friederike Ehrhart, Frederik Wiegand, Dong Yun Lee, Stefan Fischer, Yong Hwa Hwang, Anja Trenkler

Publikováno v: Xenotransplantation. 20(4)

Islet cell transplantation is a promising option for the restoration of normal glucose homeostasis in patients with type 1 diabetes. Because graft volume is a crucial issue in islet transplantations for patients with diabetes, we evaluated a new meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30210160d103bdb5c3f310a3e1aef69b
https://pubmed.ncbi.nlm.nih.gov/23789985

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Synthesis and first evaluation of new 18F-labelled sulfonylureas for the determination of the beta-cell status in vivo

Autor: S. J. Shiue, Ralf Schirrmacher, Peter J. Feilen, Stephan Schneider, A. Alavi, Frank Rösch, Grace G. Shiue, Jürgen Beyer

Publikováno v: Journal of Labelled Compounds and Radiopharmaceuticals. 44:S418-S420

The syntheses and first in vitro evaluations for two fluoride bearing sulfonylurea derivatives are reported. Firstly, the tolbutamide derivative 1-[4-(2-[18F]fluoroethoxy)benzenesulfonyl]-3-butyl urea (2-[18F]fluoroethyl-tolbutamide) could be labeled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d6e92be81d4f456be3759f53e3fee166
https://doi.org/10.1002/jlcr.25804401148

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Hydrogel-based encapsulation of biological, functional tissue: fundamentals, technologies and applications

Autor: P. Gessner, Alisa Katsen-Globa, Heiko Zimmermann, Ulrich Zimmermann, J. Metze, Peter J. Feilen, Stephen G. Shirley, Kilian J. Müller, Dirk Zimmermann, M Weber, Marcus Behringer, Gertraud Zimmermann, Friederike Ehrhart

Replacing dysfunctional endocrine cells or tissues (e.g. islets, parathyroid tissue) by functional, foreign material without using immunosuppressives could soon become reality. Immunological reactions are avoided by encapsulating cells/tissues in hyd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee83a67f50c08267c241d35b8dc1de11
https://publica.fraunhofer.de/handle/publica/215034

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