Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Peter J. Eggenhuizen"'
Autor:
Peter J. Eggenhuizen, Rachel M. Y. Cheong, Cecilia Lo, Janet Chang, Boaz H. Ng, Yi Tian Ting, Julie A. Monk, Khai L. Loh, Ashraf Broury, Elean S. V. Tay, Chanjuan Shen, Yong Zhong, Steven Lim, Jia Xi Chung, Rangi Kandane-Rathnayake, Rachel Koelmeyer, Alberta Hoi, Ashutosh Chaudhry, Paolo Manzanillo, Sarah L. Snelgrove, Eric F. Morand, Joshua D. Ooi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Antigen-specific regulatory T cells (Tregs) suppress pathogenic autoreactivity and are potential therapeutic candidates for autoimmune diseases such as systemic lupus erythematosus (SLE). Lupus nephritis is associated with autoreactivity to
Externí odkaz:
https://doaj.org/article/8948013d714c4e8e98c3470282119cef
Autor:
Peter J. Eggenhuizen, Joshua D. Ooi
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 564 (2024)
Memory T cells form from the adaptive immune response to historic infections or vaccinations. Some memory T cells have the potential to recognise unrelated pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and generate cross
Externí odkaz:
https://doaj.org/article/d9ae603fdeab475981ca134bf70adf78
Autor:
Juan Chen, Ting Meng, Jia Xu, Joshua D. Ooi, Peter J. Eggenhuizen, Wenguang Liu, Fang Li, Xueqin Wu, Jian Sun, Hao Zhang, Ya-Ou Zhou, Hui Luo, Xiangcheng Xiao, Yigang Pei, Wenzheng Li, Yong Zhong
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious studies from our group and other investigators have shown that lung involvement is one of the independent predictors for treatment resistance in patients with myeloperoxidase (MPO)–anti-neutrophil cytoplasmic antibody (ANCA)-asso
Externí odkaz:
https://doaj.org/article/4fac109ac4844fd887ac9aa2c3e46698
Autor:
Xueling Hu, Chanjuan Shen, Ting Meng, Joshua D. Ooi, Peter J. Eggenhuizen, Ya-ou Zhou, Hui Luo, Jin-biao Chen, Wei Lin, Yizi Gong, Qi Xiong, Jia Xu, Ning Liu, Xiangcheng Xiao, Rong Tang, Yong Zhong
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
BackgroundSeveral lines of evidence implicate that there are distinct differences between patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic antibody (ANCA) and anti-glomerular basement membrane (GBM) antibody double-seropositive patients
Externí odkaz:
https://doaj.org/article/058578e8fa3543c88bf4c58a6e7aaf9a
Autor:
Leilin Yu, Wei Lin, Chanjuan Shen, Ting Meng, Peng Jin, Xiang Ding, Peter J. Eggenhuizen, Joshua D. Ooi, Rong Tang, Wannian Nie, Xia Li, Xiangcheng Xiao, Yong Zhong
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
To date, the pathogenesis of hepatitis B virus (HBV)-associated membranous nephropathy (MN) remains elusive. This study aimed to decipher the etiopathogenesis of HBV-associated MN by performing single-cell RNA sequencing (scRNA-seq) of kidney biopsy
Externí odkaz:
https://doaj.org/article/d91b1e3aea6f4f1a9a1df1f56af5f390
Autor:
Xueqin Wu, Yong Zhong, Ting Meng, Joshua Daniel Ooi, Peter J. Eggenhuizen, Rong Tang, Wannian Nie, Xiangcheng Xiao, Jian Sun, Xiang Ao, Hao Zhang
Publikováno v:
Frontiers in Medicine, Vol 8 (2022)
BackgroundA significant proportion of anti-neutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis eventually progresses to end-stage renal disease (ESRD) thus requiring long-term dialysis. There is no consensus about which dialysis moda
Externí odkaz:
https://doaj.org/article/4ac2843f6c2a45e0b234ad4c045a4b8e
Autor:
Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Rachel M.Y. Cheong, Anusha Yellapragada, Wey Y. Wong, Yi Tian Ting, Julie A. Monk, Poh-Yi Gan, Stephen R. Holdsworth, Joshua D. Ooi
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Heterologous immunity, when the memory T cell response elicited by one pathogen recognizes another pathogen, has been offered as a contributing factor for the high variability in coronavirus disease 2019 (COVID-19) severity outcomes. Here we demonstr
Externí odkaz:
https://doaj.org/article/f33870b382f64739b74e931f64392c17
Autor:
Peter J. Eggenhuizen, Boaz H. Ng, Janet Chang, Ashleigh L. Fell, Rachel M. Y. Cheong, Wey Y. Wong, Poh-Yi Gan, Stephen R. Holdsworth, Joshua D. Ooi
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epidemiological studies and clinical trials suggest Bacillus Calmette-Guérin (BCG) vaccine has protective effects against coronavirus disease 2019 (COVID-19). There are now over 30 clinical trials evaluating if BCG vaccination can prevent or reduce
Externí odkaz:
https://doaj.org/article/4decf9b33a324a98b4d92aae9619899c
Autor:
Jie Xu, Chanjuan Shen, Wei Lin, Ting Meng, Joshua D. Ooi, Peter J. Eggenhuizen, Rong Tang, Gong Xiao, Peng Jin, Xiang Ding, Yangshuo Tang, Weisheng Peng, Wannian Nie, Xiang Ao, Xiangcheng Xiao, Yong Zhong, Qiaoling Zhou
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Idiopathic membranous nephropathy (IMN) is an organ-specific autoimmune disease of the kidney glomerulus. It may gradually progress to end-stage renal disease (ESRD) characterized by increased proteinuria, which leads to serious consequences. Althoug
Externí odkaz:
https://doaj.org/article/695f306c4b044b5a85df7a2c98c66d3b
Autor:
Joshua D. Ooi, Jhih-Hang Jiang, Peter J. Eggenhuizen, Ling L. Chua, Mirjan van Timmeren, Khai L. Loh, Kim M. O’Sullivan, Poh Y. Gan, Yong Zhong, Kirill Tsyganov, Lani R. Shochet, Jessica Ryan, Coen A. Stegeman, Lars Fugger, Hugh H. Reid, Jamie Rossjohn, Peter Heeringa, Stephen R. Holdsworth, Anton Y. Peleg, A. Richard Kitching
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Autoreactivity to myeloperoxidase (MPO) causes autoimmune vasculitis and severe glomerulonephritis. Here, Ooi et al. show that a Staphylococcus aureus plasmid encodes a peptide that is homologous to an immunodominant MPO epitope and induces anti-MPO
Externí odkaz:
https://doaj.org/article/ec5422e66a47466790d6d136a48ebe74