The Cerebrospinal Fluid Profile of Cholesterol Metabolites in Parkinson’s Disease and Their Association With Disease State and Clinical Features

Autor: William J. Griffiths, Jonas Abdel-Khalik, Sarah F. Moore, Ruwani S. Wijeyekoon, Peter J. Crick, Eylan Yutuc, Krista Farrell, David P. Breen, Caroline H. Williams-Gray, Spyridon Theofilopoulos, Ernest Arenas, Miles Trupp, Roger A. Barker, Yuqin Wang

Publikováno v: Frontiers in Aging Neuroscience, Vol 13 (2021)

Disordered cholesterol metabolism is linked to neurodegeneration. In this study we investigated the profile of cholesterol metabolites found in the cerebrospinal fluid (CSF) of Parkinson’s disease (PD) patients. When adjustments were made for confo

Externí odkaz: https://doaj.org/article/abaae19036454c66a3664ff79c96a45e

Defective cholesterol metabolism in amyotrophic lateral sclerosis

Autor: Jonas Abdel-Khalik, Eylan Yutuc, Peter J. Crick, Jan-Åke Gustafsson, Margaret Warner, Gustavo Roman, Kevin Talbot, Elizabeth Gray, William J. Griffiths, Martin R. Turner, Yuqin Wang

Publikováno v: Journal of Lipid Research, Vol 58, Iss 1, Pp 267-278 (2017)

As neurons die, cholesterol is released in the central nervous system (CNS); hence, this sterol and its metabolites may represent a biomarker of neurodegeneration, including in amyotrophic lateral sclerosis (ALS), in which altered cholesterol levels

Externí odkaz: https://doaj.org/article/9d8e6d3705504fb48c95baea8195e5c8

Mining for Oxysterols in Cyp7b1−/− Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Autor: Anna Meljon, Peter J. Crick, Eylan Yutuc, Joyce L. Yau, Jonathan R. Seckl, Spyridon Theofilopoulos, Ernest Arenas, Yuqin Wang, William J. Griffiths

Publikováno v: Biomolecules, Vol 9, Iss 4, p 149 (2019)

Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons i

Externí odkaz: https://doaj.org/article/848a439f0557428f8a7a0f9ecc731797

Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders

Autor: Jonas Abdel-Khalik, Alison Dickson, Douglas F. Covey, Anu Goenka, Tom Hearn, Yuqin Wang, Simon Jones, Brian W. Bigger, Arunabha Ghosh, William J. Griffiths, Teresa Hoi-Yee Wu, Eylan Yutuc, Daniel S. Ory, Peter J. Crick

Publikováno v: Griffiths, W J, Yutuc, E, Abdel-Khalik, J, Crick, P J, Hearn, T, Dickson, A, Bigger, B W, Hoi-Yee Wu, T, Goenka, A, Ghosh, A, Jones, S A, Covey, D F, Ory, D S & Wang, Y 2019, ' Metabolism of Non-Enzymatically Derived Oxysterols : Clues from sterol metabolic disorders ', Free Radical Biology and Medicine . https://doi.org/10.1016/j.freeradbiomed.2019.04.020
Free Radical Biology & Medicine

Cholestane-3β,5α,6β-triol (3β,5α,6β-triol) is formed from cholestan-5,6-epoxide (5,6-EC) in a reaction catalysed by cholesterol epoxide hydrolase, following formation of 5,6-EC through free radical oxidation of cholesterol. 7-Oxocholesterol (7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b27579309f9deacec8b4704193c0ba
https://doi.org/10.1016/j.freeradbiomed.2019.04.020

First international descriptive and interventional survey for cholesterol and non-cholesterol sterol determination by gas- and liquid-chromatography–Urgent need for harmonisation of analytical methods

Autor: Richard E. Ostlund, Bianca Barriuso, Peter B. Jones, Isabel Andrade, Semone B. Myrie, Richard W. Browne, Leena Kaipiainen, Helena Gylling, Christin Helmschrodt, Robert Ahrends, Peter J. Crick, Silke Matysik, Scott V Harding, Luigi Iuliano, Claudio Caccia, Robert Gray, Valéria S. Nunes, Chiara Zerbinati, Valerio Leoni, Dieter Lütjohann, William J. Griffiths, Iciar Astiasarán, Ana Maria Lottenberg, Ulf Diczfalusy, Hans-Gerd Janssen, Silvia Friedrichs, Gerd Schmitz, Lucía Baila-Rueda, Jeff McDonald, Lionel Bretillon, Wolf Jochen Geilenkeuser, Günter Fauler, Ana Cenarro, Guadalupe Garcia-Llatas, Ernst J. Schaefer, María Menéndez-Carreño, Ingemar Björkhem, Todd C Rideout, Anita Lövgren-Sandblom, Yuqin Wang, Anja Kerksiek, Susen Becker, Fernando Ramos, Eliana Polisecki, Frank Kannenberg, Dylan S. MacKay, Diana Ansorena, María Jesús Lagarda, Hans Frieder Schött, Uta Ceglarek

Publikováno v: Journal of Steroid Biochemistry and Molecular Biology
Journal of Steroid Biochemistry and Molecular Biology, Elsevier, 2019, 190, pp.115-125. ⟨10.1016/j.jsbmb.2019.03.025⟩
Journal of Steroid Biochemistry and Molecular Biology, 190, 115-125
Journal of Steroid Biochemistry and Molecular Biology 190 (2019)

International audience; Serum concentrations of lathosterol, the plant sterols campesterol and sitosterol and the cholesterol metabolite 5alpha-cholestanol are widely used as surrogate markers of cholesterol synthesis and absorption, respectively. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5110e25e88f406249cbf1c3f08624b82
https://cronfa.swan.ac.uk/Record/cronfa49899/Download/0049899-09052019112546.pdf